Correlating Clinical Activity and Histopathologic Assessment of Gastrointestinal Lesion Severity: Current Challenges

A presumptive case of gluten sensitivity in a border terrier: a multisystem disorder?

“…The presence of a lymphocytic-eosinophilic enteritis should be viewed with caution owing to the apparent discordance between clinical presentation and severity of inflammation and the frequent findings of enteritis in clinically silent dogs (Willard and Mansell, 2011). It is stated that the decision to biopsy should be taken only once therapeutic trials (e.g.…”

Identification of histamine receptors in the canine gastrointestinal tract

“…A lack of agreement in regards to normal histology exists, despite development of the WSAVA guidelines. 21 Significant variation in intraepithelial lymphocyte numbers occurs between normal dogs as well. 18 Furthermore, in the absence of clinical signs or other clinical criteria for inflammatory bowel disease, the current veterinary literature does not explain the significance of histopathological abnormalities in the GI tract of healthy dogs.…”

“…5 Other potential uses of H2 antagonists include cardioprotection in ischemic conditions and improvement of cognitive function. 18,21 …”

Cytology of endoscopically obtained biopsies for the diagnosis of chronic intestinal diseases in cats

“…In many cats with chronic GI disease, there is inconsistency between clinical course, ultrasound results, endoscopy findings and histopathological diagnosis. Clinical indices have been developed in order to facilitate the diagnosis of feline IBD (13,29). As no such information is included in this study, the diagnosis of IBD relies solely on the histopathological description.…”