2021
DOI: 10.21203/rs.3.rs-1125604/v1
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Correlating MRI-Based Brain Volumetry and Cognitive Assessment in Down Syndrome Patients

Abstract: INTRODUCTION: Down syndrome (DS) is the most common genetic cause of intellectual disability. Here, we use magnetic resonance imaging (MRI) on children and adults with DS to characterize changes in the volume of specific brain structures involved in memory and language and their relationship to features of cognitive-behavioral phenotypes.METHODS: Thirteen children and adults with the DS phenotype and 12 age- and gender-matched healthy controls were analyzed by MRI and underwent a psychological evaluation for l… Show more

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