Correlating Sperm Reactive Oxygen Species Production and Its Morphological Defects – Which Can Be the Best Possible Morphological Predictor of Oxidative Damage in Routine Screening?

Abstract

Introduction:Male infertility contributes to nearly 30% of the total infertile population worldwide. Despite the advances in diagnostic workup of an infertile male in majority (40-50%) of the cases aetiology is not defined. Supra-physiological levels of ROS impair sperm function by damaging polyunsaturated fatty acid-rich sperm membrane and mitochondrial and nuclear DNA.