2017
DOI: 10.1002/hed.24895
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Correlation among ocular surface disease, xerostomia, and nasal symptoms in patients with differentiated thyroid carcinoma subjected to radioiodine therapy: A prospective comparative study

Abstract: Subjective worsening of xerostomia, xerophthalmia, nasal symptoms, and changes in the nasal mucosa in group 1 was observed.

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Cited by 11 publications
(19 citation statements)
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“…There is a small body of literature evaluating the effect of RAI treatment on lacrimal gland function, manifesting typically as eye dryness, pruritus and other secondary ocular surface abnormalities. Often patients with ocular symptoms demonstrate minimal or no objective findings that correlate with their disease 22‐25 . Fortunately, in most patients, these ophthalmic symptoms tend to decrease over the first 3 years after treatment 25…”
Section: Pathophysiologymentioning
confidence: 99%
See 1 more Smart Citation
“…There is a small body of literature evaluating the effect of RAI treatment on lacrimal gland function, manifesting typically as eye dryness, pruritus and other secondary ocular surface abnormalities. Often patients with ocular symptoms demonstrate minimal or no objective findings that correlate with their disease 22‐25 . Fortunately, in most patients, these ophthalmic symptoms tend to decrease over the first 3 years after treatment 25…”
Section: Pathophysiologymentioning
confidence: 99%
“…Three months after RAI treatment, approximately 10% of patients complain of nasal symptoms 27 . While cells within the nasolacrimal ducts express the sodium iodine symporter, nasal tissues do not 24,28‐30 . Thus, the mechanism of nasal‐induced RAI symptoms is still not entirely understood.…”
Section: Pathophysiologymentioning
confidence: 99%
“…Iodine‐131 (I 131 ) therapy is associated with a high prevalence of side effects, especially salivary and lacrimal gland dysfunction (Sicca syndrome), nasal dryness, gustatory dysfunction, and dysphagia 3‐9 …”
Section: Introductionmentioning
confidence: 99%
“…Клиническим проявлением поражения слезных желез и нарушения слезопродукции является развитие сухого кератоконъюнктивита. Стоит отметить, что почти в четверти наблюдаемых случаев изменения имеют транзиторный характер и не требуют какой-либо специальной коррекции [ 11 ][ 20 ][ 21 ]. Авторы, проводившие исследования, которые касались патоморфологических изменений слезной железы после воздействия 131I, пришли к заключению, что в основе механизма поражения лежит оксидативный стресс, индуцированный ионизирующим излучением [ 22 ].…”
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