Correlation analysis of IL-11 polymorphisms and Hirschsprung disease subtype susceptibility in Southern Chinese Children

Zhang, Hong; Zhao, Jianhao; Zheng, Yi; Xie, Xiaoli; Huang, Lihua; Li, Le; Zhu, Yun; Lu, Li-Feng; Hu, Tuqun; Zhong, Wei; He, Qiuming

doi:10.1186/s12920-020-00867-x

Cited by 3 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The incidence of preoperative HAEC at our hospital was 18.8%, and postoperative HAEC was 15.4%, which is similar to previous reports. The etiology and mechanism of HAEC are not fully understood, and most of the studies have focused on gut microbiota, intestinal epithelial barrier function, and genes ( 4 – 7 ). It is essential to identify the risk factors of HAEC and provide prompt clinical interventions.…”

Section: Discussionmentioning

confidence: 99%

Microcytic hypochromic Anemia is a risk factor for postoperative HAEC: A retrospective study

Huang

Ren²

2023

Front. Surg.

View full text Add to dashboard Cite

BackgroundHirschsprung-associated enterocolitis (HAEC) is a common and life-threatening complication of Hirschsprung's disease (HSCR), which can occur before and after surgery. The aim of this study was to identify the risk factors associated with the development of HAEC.MethodsWe retrospectively reviewed the medical records of HSCR patients admitted to the Children's Hospital of Shanxi Province, China, between January 2011 and August 2021. Diagnosis of HAEC was made using a scoring system with cutoff values ≥4 and included the patient's history, physical examination, and radiological and laboratory findings. The results are shown as frequency (%). The chi-square test was used to analyze a single factor with a significance level of P < 0.05. Logistic regression analysis was used to analyze multiple factors.ResultsA total of 324 patients were included in this study, with 266 males and 58 females. In total, 34.3% (111/324) of patients had HAEC, including 85 males and 26 females; 18.9% (61/324) of patients had preoperative HAEC; and 15.4% (50/324) of patients had postoperative HAEC within one year after surgery. Gender, age at definitive therapy, and feeding methods were not found to be associated with preoperative HAEC in univariate analysis. Respiratory infection was associated with preoperative HAEC (P = 0.00003). No association was found between gender and age at definitive therapy and postoperative HAEC. Postoperative HAEC was associated with microcytic hypochromic anemia (P = 0.00058), preoperative history of HAEC (P = 0.00120), the creation of a preoperative stoma (P = 0.00097), long segment or total colon HSCR (P = 0.00057), and hypoalbuminemia (P = 0.03225). Regression analysis showed that microcytic hypochromic anemia (OR=2.716, 95% CI = 1.418–5.203, P = 0.003), preoperative history of HAEC (OR=2.814, 95% CI = 1.429–5.542, P = 0.003), the creation of a preoperative stoma (OR=2.332, 95% CI = 1.003–5.420, P = 0.049), and long segment or total colon HSCR (OR=2.167, 95% CI = 1.054–4.456, P = 0.035) were associated with postoperative HAEC.ConclusionThis study revealed that the incidence of preoperative HAEC at our hospital was associated with respiratory infections. In addition, microcytic hypochromic anemia, preoperative history of HAEC, the creation of a preoperative stoma, and long segment or total colon HSCR were risk factors of postoperative HAEC. The most important finding of this study was that microcytic hypochromic anemia was a risk factor for postoperative HAEC, which has been rarely reported. Further studies with larger sample sizes are necessary to confirm these findings.

show abstract

Section: Discussionmentioning

confidence: 99%

Microcytic hypochromic Anemia is a risk factor for postoperative HAEC: A retrospective study

Huang

Ren²

2023

Front. Surg.

View full text Add to dashboard Cite

show abstract

The role of interleukin‐36 in health and disease states

Sugiura,

Fujita,

Komine

et al. 2024

Acad Dermatol Venereol

View full text Add to dashboard Cite

The interleukin (IL)‐1 superfamily upregulates immune responses and maintains homeostasis between the innate and adaptive immune systems. Within the IL‐1 superfamily, IL‐36 plays a pivotal role in both innate and adaptive immune responses. Of the four IL‐36 isoforms, three have agonist activity (IL‐36α, IL‐36β, IL‐36γ) and the fourth has antagonist activity (IL‐36 receptor antagonist [IL‐36Ra]). All IL‐36 isoforms bind to the IL‐36 receptor (IL‐36R). Binding of IL‐36α/β/γ to the IL‐36R recruits the IL‐1 receptor accessory protein (IL‐1RAcP) and activates downstream signalling pathways mediated by nuclear transcription factor kappa B and mitogen‐activated protein kinase signalling pathways. Antagonist binding of IL‐36Ra to IL‐36R inhibits recruitment of IL‐1RAcP, blocking downstream signalling pathways. Changes in the balance within the IL‐36 cytokine family can lead to uncontrolled inflammatory responses throughout the body. As such, IL‐36 has been implicated in numerous inflammatory diseases, notably a type of pustular psoriasis called generalized pustular psoriasis (GPP), a chronic, rare, potentially life‐threatening, multisystemic skin disease characterised by recurrent fever and extensive sterile pustules. In GPP, IL‐36 is central to disease pathogenesis, and the prevention of IL‐36‐mediated signalling can improve clinical outcomes. In this review, we summarize the literature describing the biological functions of the IL‐36 pathway. We also consider the evidence for uncontrolled activation of the IL‐36 pathway in a wide range of skin (e.g., plaque psoriasis, pustular psoriasis, hidradenitis suppurativa, acne, Netherton syndrome, atopic dermatitis and pyoderma gangrenosum), lung (e.g., idiopathic pulmonary fibrosis), gut (e.g., intestinal fibrosis, inflammatory bowel disease and Hirschsprung's disease), kidney (e.g., renal tubulointerstitial lesions) and infectious diseases caused by a variety of pathogens (e.g., COVID‐19; Mycobacterium tuberculosis, Pseudomonas aeruginosa, Streptococcus pneumoniae infections), as well as in cancer. We also consider how targeting the IL‐36 signalling pathway could be used in treating inflammatory disease states.

show abstract

Update on the Pathogenesis of the Hirschsprung-Associated Enterocolitis

Zhang

et al. 2023

IJMS

View full text Add to dashboard Cite

Despite the significant progress that has been made in terms of understanding the pathophysiology and risk factors of Hirschsprung-associated enterocolitis (HAEC), the morbidity rate has remained unsatisfactorily stable, and clinical management of the condition continues to be challenging. Therefore, in the present literature review, we summarized the up-to-date advances that have been made regarding basic research on the pathogenesis of HAEC. Original articles published between August 2013 and October 2022 were searched in a number of databases, including PubMed, Web of Science, and Scopus. The keywords “Hirschsprung enterocolitis”, “Hirschsprung’s enterocolitis”, “Hirschsprung’s-associated enterocolitis”, and “Hirschsprung-associated enterocolitis” were selected and reviewed. A total of 50 eligible articles were obtained. The latest findings of these research articles were grouped into gene, microbiome, barrier function, enteric nervous system, and immune state categories. The present review concludes that HAEC is shown to be a multifactorial clinical syndrome. Only deep insights into this syndrome, with an accrual of knowledge in terms of understanding its pathogenesis, will elicit the necessary changes that are required for managing this disease.

show abstract

Correlation analysis of IL-11 polymorphisms and Hirschsprung disease subtype susceptibility in Southern Chinese Children

Cited by 3 publications

References 16 publications

Microcytic hypochromic Anemia is a risk factor for postoperative HAEC: A retrospective study

Microcytic hypochromic Anemia is a risk factor for postoperative HAEC: A retrospective study

The role of interleukin‐36 in health and disease states

Update on the Pathogenesis of the Hirschsprung-Associated Enterocolitis

Contact Info

Product

Resources

About