Correlation Analysis of Mood State and Symptom Clusters in Patients With Stage-Ⅳ Lung Cancer During Immunotherapy

Abstract

Purpose: To investigate the status of symptom clusters and mood states and analyze the correlation between them in patients with stage-IV lung cancer undergoing immunotherapy.Methods: Using a convenience sampling method, we selected 259 patients for analysis with stage-IV lung cancer who were admitted to the oncology department of a hospital for immunotherapy from February to December 2020. Three instruments were used: a general situation questionnaire, the Chinese version of the M. D. Anderson Symptom Inventory, and the Brief Profile of Mood State Short Form.Results: An exploratory factor analysis identified three main symptom clusters: the disturbance influence, general, and pain–fatigue related symptom clusters. The total score for mood state was (25.71 SD: ±8.32). The score of the depression dimension was the highest (3.30 ±1.85) in the negative mood state; the total score of mood state and the score of negative mood state at different latitudes were significantly positively correlated with the total score of symptom clusters (r = 0.420–0.529, p < 0.01).Conclusion: There are many symptom clusters in patients with lung cancer undergoing immunotherapy. The negative mood state is significant and changes along with changes in symptom clusters; moreover, there is high correlation between them. There should be more focus on the evaluation and management of symptom clusters of patients in nursing to improve the patients’ quality of life.