Correlation analysis of phenolic compounds, antioxidant potential, oxygen radical scavenging capacity, and alkaloid content in ripe and unripe Areca catechu from major cultivation areas in Sri Lanka

Rangani, S.C.; Marapana, R.A.U.J.; Senanayake, G.S.A.; Perera, P.R.D.; Pathmalal, M.M.; Amarasinghe, H.K.

doi:10.1016/j.afres.2023.100361

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…However, it has been used for thousands of years in traditional Chinese and Indian medicine, and the areca nut has anthelmintic properties [ 13 ]. This may be because the areca nut is rich in polyphenols [ 14 ]. LPS is an endotoxin whose physiological role is manifested through Toll-like receptor 4 present on the surface of the cell membrane of the host cell [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Ameliorative Effect of Areca Nut Polyphenols on Adverse Effects Induced by Lipopolysaccharides in RAW264.7 Cells

Zou,

Yi,

Wang

2024

Molecules

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In Asian regions, areca nuts are tropical fruits that are extensively consumed. The areca nut contains a lot of polyphenols and its safety is unknown. In this research, we investigated the effects of lipopolysaccharides (LPS) and areca nut polyphenols (ANP) on normal RAW264.7 cells. The results showed that LPS stimulated adverse effects in normal cells by affecting cytokine production. The GO analysis results mainly affected DNA repair, cell division, and enzyme activities. In the KEGG analysis results, the NOD-like receptor signaling pathway, which is related to NF-κB, MAPK, and the pro-inflammatory cytokines, is the most significant. In the protein–protein interaction network (PPI) results, significant sub-networks in all three groups were shown to be related to cytokine–cytokine receptor interaction. Collectively, our findings showed a comprehensive understanding of LPS-induced toxicity and the protective effects of ANP by RNA sequencing.

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Section: Discussionmentioning

confidence: 99%

Ameliorative Effect of Areca Nut Polyphenols on Adverse Effects Induced by Lipopolysaccharides in RAW264.7 Cells

Zou,

Yi,

Wang

2024

Molecules

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Research on Plant Crop Sales Prediction Based on Correlation Clustering and Product Attributes

Zhao,

Bai,

Yang

et al. 2023

2023 4th International Conference on Machine Learning and Computer Application

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Characterization of Phenolic Profile and Biological Properties of Astragalus membranaceus Fisch. ex Bunge Commercial Samples

Shahrivari-Baviloliaei,

Erdogan Orhan,

Abaci Kaplan

et al. 2024

Antioxidants

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Astragalus membranaceus Fisch. ex Bunge (syn. Astragalus mongholicus Bunge) is one of the notable medicinal and food plants. Therefore, the aim of this study was to calculate the phenolic composition and antioxidant, antimicrobial, as well as enzyme inhibitory [acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and tyrosinase (TYR)] activities with chemometric approaches of the hydromethanolic and water extracts of commercial A. membranaceus samples. Ten individual phenolic compounds were determined using high-performance liquid chromatography (HPLC), and only quercetin was found at a level of above 80 µg/g DW in both extracts. Moreover, the highest antioxidant activity in DPPH, FRAP, ABTS, and CUPRAC assays was found in the sample containing the roots in loose form from USA. A. membranaceus extracts displayed the inhibition zone diameters within the range from 10 to 22 mm antimicrobial activity against S. aureus, while there were no inhibition zones in any extracts in case of E. coli. The extracts of A. membranaceous showed an inhibition rate below 40% against TYR, and among tested extracts, only two samples were able to inhibit BChE with IC50 values of above 30 µg/mL. Correlation analysis showed a highly positive relationship between their phenolic composition and antioxidant activity. Concluding, the obtained results confirmed that A. membranaceus commercial samples could be an important dietary source of natural antioxidants.

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Correlation analysis of phenolic compounds, antioxidant potential, oxygen radical scavenging capacity, and alkaloid content in ripe and unripe Areca catechu from major cultivation areas in Sri Lanka

Cited by 3 publications

References 30 publications

Ameliorative Effect of Areca Nut Polyphenols on Adverse Effects Induced by Lipopolysaccharides in RAW264.7 Cells

Ameliorative Effect of Areca Nut Polyphenols on Adverse Effects Induced by Lipopolysaccharides in RAW264.7 Cells

Research on Plant Crop Sales Prediction Based on Correlation Clustering and Product Attributes

Characterization of Phenolic Profile and Biological Properties of Astragalus membranaceus Fisch. ex Bunge Commercial Samples

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