Correlation between 5-HT, Hcy and the incidence and severity of autism in children

Li, Xiao-Xue

doi:10.14715/cmb/2022.69.1.10

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…5-HT neurotransmission dysfunction and circuit dysregulation may underlie the behavioral abnormalities associated with ASD ( 64 ). Patients with ASD often exhibit hyper-serotonemia, and 5-HT levels are significantly predictive of ASD development ( 65 ). Its receptor serotonin transporter protein (SERT) was found to regulate synaptic serotonin, modulating mitochondrial copy number and mitochondrial respiratory complex gene expression in the frontal cortex and cerebellum in a sexually dimorphic manner, which could help explain the gender bias in ASD prevalence ( 66 ).…”

Section: Neural Pathwaysmentioning

confidence: 99%

Neuroplasticity of children in autism spectrum disorder

Chen,

Wang,

Zhang

et al. 2024

Front. Psychiatry

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder that encompasses a range of symptoms including difficulties in verbal communication, social interaction, limited interests, and repetitive behaviors. Neuroplasticity refers to the structural and functional changes that occur in the nervous system to adapt and respond to changes in the external environment. In simpler terms, it is the brain’s ability to learn and adapt to new environments. However, individuals with ASD exhibit abnormal neuroplasticity, which impacts information processing, sensory processing, and social cognition, leading to the manifestation of corresponding symptoms. This paper aims to review the current research progress on ASD neuroplasticity, focusing on genetics, environment, neural pathways, neuroinflammation, and immunity. The findings will provide a theoretical foundation and insights for intervention and treatment in pediatric fields related to ASD.

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Section: Neural Pathwaysmentioning

confidence: 99%

Neuroplasticity of children in autism spectrum disorder

Chen,

Wang,

Zhang

et al. 2024

Front. Psychiatry

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Personalized repetitive transcranial magnetic stimulation guided by the spectral electroencephalogram may enhance and democratize therapy for autism spectrum disorder

Makale,

Blum,

Bowirrat

et al. 2024

Medical Hypotheses

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A Systematic Review on Autism and Hyperserotonemia: State-of-the-Art, Limitations, and Future Directions

Esposito,

Cruciani,

Zaccaro

et al. 2024

Brain Sciences

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Hyperserotonemia is one of the most studied endophenotypes in autism spectrum disorder (ASD), but there are still no unequivocal results about its causes or biological and behavioral outcomes. This systematic review summarizes the studies investigating the relationship between blood serotonin (5-HT) levels and ASD, comparing diagnostic tools, analytical methods, and clinical outcomes. A literature search on peripheral 5-HT levels and ASD was conducted. In total, 1104 publications were screened, of which 113 entered the present systematic review. Of these, 59 articles reported hyperserotonemia in subjects with ASD, and 26 presented correlations between 5-HT levels and ASD-core clinical outcomes. The 5-HT levels are increased in about half, and correlations between hyperserotonemia and clinical outcomes are detected in a quarter of the studies. The present research highlights a large amount of heterogeneity in this field, ranging from the characterization of ASD and control groups to diagnostic and clinical assessments, from blood sampling procedures to analytical methods, allowing us to delineate critical topics for future studies.

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Correlation between 5-HT, Hcy and the incidence and severity of autism in children

Cited by 3 publications

References 23 publications

Neuroplasticity of children in autism spectrum disorder

Neuroplasticity of children in autism spectrum disorder

Personalized repetitive transcranial magnetic stimulation guided by the spectral electroencephalogram may enhance and democratize therapy for autism spectrum disorder

A Systematic Review on Autism and Hyperserotonemia: State-of-the-Art, Limitations, and Future Directions

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