Correlation between angiographically assessed vascularity and blood flow in hepatic metastases in patients with colorectal carcinoma

Relationships between oxygen and glucose metabolism in human liver tumours: positron emission tomography using 15O and 18F-deoxyglucose

“…However, in measuring the regional metabolic rate of oxygen, we used Ft, which we obtained by a dynamic H 2 15 O method. Steady-state methods are far inferior to dynamic methods [15] in their ability to quantify blood flow in a metastasis [16] because r, the tumour-blood equilibrium partition coefficient for water, is assumed to be unity in steady-state calculations. In contrast, the H 2 15 O dynamic method can measure r using non-linear multiple regression analysis for each tumour, as different hepatic tumours may require different values for this coefficient.…”

“…In contrast, the H 2 15 O dynamic method can measure r using non-linear multiple regression analysis for each tumour, as different hepatic tumours may require different values for this coefficient. Therefore, the dynamic method [16][17][18], rather than the steady-state method, was used for Ft. In addition, the results obtained from liver tumour quantification using PET images were parallel to the angiographic and dynamic CT results [16][17][18].…”

“…Therefore, the dynamic method [16][17][18], rather than the steady-state method, was used for Ft. In addition, the results obtained from liver tumour quantification using PET images were parallel to the angiographic and dynamic CT results [16][17][18]. 18 FDG study that were already very complicated.…”

“…According to Equations 4 and 5, MRO 2 can be increased by up-regulating Ft, OEF, haemoglobin and/or SaO 2 . Yamaguchi et al [16] have suggested that the blood flow in liver tissue that harbours metastases from colorectal carcinoma is greater than that in normal liver without metastases. Tumour-induced neovascularization is a well-known mechanism increasing tumour blood flow.…”

Chemoembolization in the Management of Liver Tumors

“…Building on this work, chemoembolization Stuart 432 has been investigated for unresectable lesions in this population. Tumor response rates are not as high as those in HCC and neuroendocrine metastases because colorectal lesions are frequently hypovascular on arteriography [107,108], limiting the ability to deliver adequate chemotherapy and embolic agents. Nonetheless, response rates of approximately 50% have been reported, with survival longer than would be expected in studies of systemic therapy among patients who had failed standard chemotherapy.…”