Correlation between arterial stiffness and coronary flow velocity reserve in subjects with pulse wave velocity >1400 cm/s

Abstract

Brachial-ankle pulse wave velocity (ba-PWV) is an independent predictor for cardiovascular events. Coronary flow velocity reserve (CFVR) provides important information for coronary endothelial function. In the present study, we investigated the possible relationship between PWV and CFVR, especially in subjects with PWV > 1400 cm/s. Seventy five subjects were divided into two groups based on baPWV value (baPWV > 1400 cm/s versus baPWV < 1400 cm/s). PWV and CFVR were measured by Colin VP-1000 apparatus and non-invasive Doppler echocardiography, respectively. Our results showed that CFVR was significantly lower in patients with baPWV > 1400 cm/s than in patients with baPWV < 1400 cm/s (2.57 ± 0.68 versus 3.04 ± 0.73, p < 0.01). baPWV was negatively correlated with CFVR in the entire study group (r = -0.45, p < 0.0001) even adjusting for age, prevalence of diabetes mellitus and systolic blood pressure (r = -0.33, p = 0.044). Moreover, baPWV was markedly negatively correlated with CFVR in patients with baPWV > 1400 cm/s (r = -0.42, p < 0.01). Multiple linear regressions showed that baPWV was independently associated with CFVR in the entire study group (β = -0.702, p < 0.001). Our results showed that large arterial stiffness was negatively correlated with decreased CFVR especially in subjects with baPWV > 1400 cm/s, and baPWV was independently associated with CFVR.

Impaired coronary microcirculation is associated with left ventricular diastolic dysfunction in end‐stage chronic kidney disease patients

“…Increased arterial stiffness has been associated with impaired CFR in various populations indicating a widespread vascular dysfunction that is not limited to a single vascular bed in high atherosclerotic risk patients. Furthermore, it has been suggested that higher aortic PWV and increased central aortic arterial wave reflections may impose a greater afterload burden to the left ventricle leading to LV hypertrophy, diastolic, and systolic dysfunction and probably further deterioration of coronary microcirculation.…”

Exenatide exerts direct protective effects on endothelial cells through the AMPK/Akt/eNOS pathway in a GLP-1 receptor-dependent manner

“…CFVR assessed by transthoracic Doppler echocardiography is an effective method to evaluate coronary endothelial function (21). Our previous studies demonstrated a positive association between CFVR and endothelial function in patients either with type 2 diabetes-associated coronary artery disease or with hyperhomocysteinemia (18,27,39). CFVR could be upregulated by some hypoglycemic and lipid-lowing drugs such as the peroxisome proliferator-activated receptor (PPAR)-␥ agonist rosiglitazone and the PPAR␣ agonist fenofibrate (35,40).…”

“…Reduced CFVR is an early prognostic indicator of coronary atherosclerotic heart disease (28). Our previous studies also demonstrated a positive association between CFVR and endothelial function in patients either with type 2 diabetes-associated coronary artery disease or with hyperhomocysteinemia (18,27,39).…”