Correlation between blood compatibility and physical surface properties of titanium-based coatings

Tsyganov, I. A.; Maitz, Manfred F.; Wieser, E.; Richter, E.; Reuther, H.

doi:10.1016/j.surfcoat.2005.02.093

Cited by 52 publications

(24 citation statements)

References 14 publications

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“…Unfortunately, the cell viability is not high enough to use this alloy in the human body and require additional processes such as coating with titanium to increase the corrosion resistance and to prevent the release of toxic ions [10,11]. Haemocompatibility tests will be done to evaluate the blood reactions.…”

Section: Discussionmentioning

confidence: 99%

Biocompatibility of Candidate Materials for the Realization of Medical Microdevices

Pouponneau¹,

Yahia²,

Merhi³

et al. 2006

2006 International Conference of the IEEE Engineering in Medicine and Biology Society

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The propulsion of ferromagnetic micro-carriers in the blood vessels by magnetic gradients generated from a Magnetic Resonance Imaging (MRI) system is of special interest for targeted interventions such as chemotherapy or chemo-embolization. As such, Fe-Co alloys for its highest magnetization saturation, and single crystal Ni-Mn-Ga powder and Terfenol-D for their deformation in magnetic field are evaluated for their biocompatibility. The toxicity of these materials is evaluated with MTT cell viability tests. The tests show that Fe-Co (Permendur and Vacoflux 17) alloys are toxic within 24 hours while the single crystal Ni-Mn-Ga powder becomes toxic after 48 hours. The Terfenol-D, despite its high degradation, has 90% cell viability after 72 hours. These results indicate that such candidate materials to be considered in untethered micro-carriers or devices in the blood vessels, would require, depending upon the time spent in the blood vessels, further processes to be viable for such applications.

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Section: Discussionmentioning

confidence: 99%

Biocompatibility of Candidate Materials for the Realization of Medical Microdevices

Pouponneau¹,

Yahia²,

Merhi³

et al. 2006

2006 International Conference of the IEEE Engineering in Medicine and Biology Society

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“…Proofs of these statements are presented in publications [9][10][11][12][13][14][15][16][17][18]. There are materials similar to the structure of the tissue.…”

Section: An Important Aspect In the Development Of An Effective Treatmentioning

confidence: 98%

Bio-Inspiered Blood-Contacting Materials Elaborated For The Heart Assist System

Major¹

2015

Archives of Metallurgy and Materials

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I dedicate this work to my Father, who is also my Mentor.He has enabled me to execute my professional passion.The paper presents the main achievements of the author on the development of blood contacting materials. The main objective of the work is to elaborate materials dedicated for the heart support systems. Appropriately designed biomaterial surfaces enable fully controlled cellular differentiation, proliferation, and even restoration of the tissue structure on solids. The paper presents two approaches to modify the surface, which can control the life processes of tissue. The first solution considers the topography in the form of cell niches. The main objective of the study is a modified surface of thin films deposited on the polymer substrate constituting the microenvironment for the cells caused by residual stress and optimized stiffness of the surface using the plasma methods. The research hypothesis was the plasma surface modification method generating a controlled contribution of residual stress in the coating affect the surface topography in the form of nano-wrinkles similar to the niches in the tissue environment. Topography and stiffness of the surface coating allows the targeted cellular differentiation. The properly formed surface topography effectively inhibits blood clotting processes. The second solution considers implementation of self-organizing feature of extracellular matrix like coatings and selective cell mobilization. The multiscale analysis and phenomenologic description were performed to experimental research. For this purpose, the deposition method was based on electrostatic interactions in polyelectrolytes. This type of cell-polymer structure imitate the native structures.Keywords: Surface modification, cell-material interaction, tissue precursors, materials for regenerative medicine Praca przedstawia najważniejsze osiągniecia autora dotyczące rozwoju materiałów do kontaktu z krwią. Głównym celem prowadzonych prac są materiały o przeznaczeniu w komorach wspomagania serca. Odpowiednio zaprojektowana powierzchnia biomateriału umożliwia w pełni kontrolowane różnicowanie komórkowe, proliferację i nawet odtworzenie struktury tkanki na ciele stałym. W pracy przedstawiono dwa podejścia modyfikacji powierzchniowej, które pozwalają sterować procesami życio-wymi tkanki. Pierwszym rozwiązaniem są powłoki o topografii nisz komórkowych. Celem głównym badań jest zmodyfikowana powierzchnia materiałów cienkowarstwowych nałożonych na podłoże polimerowe stanowiąca mikrośrodowisko dla wychwytu i kontrolowanego różnicowania komórek uzyskane przez odpowiedni udział naprężeń własnych i zoptymalizowaną sztywność powierzchniową. Ukierunkowana mikrostrukturą i właściwościami powierzchniowymi monowarstwa hamuje procesy wykrzepiania krwi. Drugie rozwiązanie dotyczy powłok o strukturze macierzy zewnątrzkomórkowej. Celem badań jest wieloskalowa analiza i opis fenomenologiczny samoorganizujących się powłok z funkcją selektywnej mobilizacji komórkowej. Jest to nowoczesne podejście na poziomie badań eksperymentalnyc...

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“…The best solutions are associated with the biomimetic surface of materials introduced into the human body. The combination of tissue engineering and materials science in the design of novel biomedical materials is now a worldwide trend [1][2][3][4][5][6][7][8][9][10]. In the treatment of cardiovascular diseases, tissue analogues reduce the risk of rejection and increase the chances for better and longer implantation with reduced immunosuppression support.…”

Section: Introductionmentioning

confidence: 99%

Biomimmetic surfaces effectively inhibiting coagulation process dedicated for cardiovascular devices

Major¹

2016

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Biomimmetic surfaces effectively inhibiting coagulation process dedicated for cardiovascular devicesThe work focused on developing coatings with niche-like surfaces that resemble stem cells. Structures similar to stem cell niches were designed to inhibit the fast division process and subsequently to influence the efficient endothelialisation. Using a plasma method, the surface topography and stiffness, as well as the microstructure, were modified by controlled residual stresses. The cells exhibited a potential for formation of the appropriate endothelial layer. Residual stresses affected the formation of the surface topography in a form of nano-wrinkles similar to niches in the tissue environment where stem cells are stored. Carbon-based films were deposited on reference substrates using a magnetron sputtering technique. Amorphous carbon and diamond like carbon with anode laser source were studied in the work. Niche-like structures were designed to catch stem cells from blood flow and prevent their rapid differentiation. The blood-material interaction under dynamic conditions was performed and described. Blood from above the analysed surface was collected after the test, and the quality of the blood was assessed along with the type of cellular response to the surface. The potential for endothelialisation was adjusted using human umbilical vein endothelium cells. The contact angle measurement was performed giving initial output information for tests on blood. The biomimetic approach considered nichelike structures reconstruction using materials science. In the work we have developed coatings that could mobilize and influence the differentiation of vascular endothelial cells.

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Correlation between blood compatibility and physical surface properties of titanium-based coatings

Cited by 52 publications

References 14 publications

Biocompatibility of Candidate Materials for the Realization of Medical Microdevices

Biocompatibility of Candidate Materials for the Realization of Medical Microdevices

Bio-Inspiered Blood-Contacting Materials Elaborated For The Heart Assist System

Biomimmetic surfaces effectively inhibiting coagulation process dedicated for cardiovascular devices

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