Correlation between body mass index and striatal dopamine transporter availability in healthy volunteers—A SPECT study

Chen, Po See; Yang, Yen Kuang; Yeh, Tzung Lieh; Lee, I‐Hui; Yao, Wei Jen; Chiu, Nan Tsing; Lu, Ru Band

doi:10.1016/j.neuroimage.2007.11.007

Cited by 91 publications

(106 citation statements)

References 47 publications

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“…26,35 BMI was highly correlated with age in our study. Our previous study suggested that, when measuring striatal DAT, BMI, instead of age, should be considered to be a covariate.…”

Section: Discussionsupporting

confidence: 67%

“…Our previous study suggested that, when measuring striatal DAT, BMI, instead of age, should be considered to be a covariate. 26 After adjustment for the effect of age, there was still a significant negative association between striatal DAT availability and perseverative errors.…”

Section: Discussionmentioning

confidence: 95%

“…Only variables that were significantly correlated with DAT were included in the regression analyses, including age, body mass index (BMI) and daily life events. 25,26 We used Pearson correlation (r) to explore the relation between 2 continuous variables. According to the results of our previous studies 25,26 and the result of multiple linear regression, BMI, rather than age or daily life events, should be considered as a covariate when measuring striatal DAT availability.…”

Section: Discussionmentioning

confidence: 99%

“…25,26 We used Pearson correlation (r) to explore the relation between 2 continuous variables. According to the results of our previous studies 25,26 and the result of multiple linear regression, BMI, rather than age or daily life events, should be considered as a covariate when measuring striatal DAT availability. Therefore, partial correlation was applied to explore the relation between striatal DAT availability and perseverative errors in the WCST.…”

Section: Discussionmentioning

confidence: 99%

“…[23][24][25] The characteristics of 50 of these participants have been described previously. 26 We excluded participants with any past or present psychiatric or neurologic disorder, alcohol or substance abuse (except for caffeine and nicotine), serious medical or surgical conditions that could alter cognitive function, or a history of head trauma with loss of consciousness. We also excluded those with a family history of psychosis in a first-degree relative.…”

Section: Participantsmentioning

confidence: 99%

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Correlation between errors on the Wisconsin Card Sorting Test and the availability of striatal dopamine transporters in healthy volunteers

Hsieh

Yeh

Lee³

et al. 2010

jpn

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Background: Although studies have indicated that the frontal lobe plays an important role in performance on the Wisconsin Card Sorting Test (WCST) and that basal ganglia play a specific role in frontal lobe function, the role of striatal dopamine (DA) activity in performance on the WCST remains unclear. Methods: We assessed the relation between the availability of striatal dopamine transporters (DATs) and performance on the WCST as a measure of executive function in healthy individuals. We approximated the availability of DATs in 53 healthy volunteers aged 19-61 years by use of single photon emission computed tomography with technetium-99m ( 99m Tc)-TRODAT-1 as the ligand. The WCST was administered to all participants. Results: The availability of DAT was significantly negatively correlated with perseverative errors on the WCST, both before and after adjustment for body mass index (r before = -0.39, p = 0.004; r after = -0.39, p = 0.005). Limitations: This was an association study; thus, a causal relation between DAT availability and performance cannot be confirmed. Conclusion: Our results suggest that striatal DAT availability may play a role in executive function as measured by the WCST.

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“…26,35 BMI was highly correlated with age in our study. Our previous study suggested that, when measuring striatal DAT, BMI, instead of age, should be considered to be a covariate.…”

Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

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Correlation between errors on the Wisconsin Card Sorting Test and the availability of striatal dopamine transporters in healthy volunteers

Hsieh

Yeh

Lee³

et al. 2010

jpn

Self Cite

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No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [¹²³I]PE2I

Thomsen

Ziebell

Jensen

et al. 2013

Obesity

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Objective: Dopamine plays an important role in both the rewarding and conditioning effects of food. These effects involve mesolimbic, mesocortical, and nigrostriatal pathways. In humans, the most consistent finding has been reduced striatal dopamine D 2/3 receptor availability. In striatum, dopamine is inactivated by reuptake via the dopamine transporter (DAT). The aim of the study was to test the hypothesis of lower DAT availability in obese healthy subjects using a selective DAT radiotracer in a sample of subjects with a wide range of BMI values. Design and Methods: Thirty-three healthy subjects with a mean age of 48.4 6 13.3 (range, 21-71) years and a mean BMI of 29.6 6 7.8 kg/m 2 (range, 21.0-49.5) were included in the study. We used [123 I]PE2I and SPECT to measure DAT availability. Results: Using multiple linear regression analyses with striatal DAT as the dependent variable and BMI, age and gender as predictors was performed. We found no correlation between BMI and striatal DAT availability in striatum (P ¼ 0.99), caudate nucleus (P ¼ 0.61), and putamen (P ¼ 0.30). Furthermore, we found no group difference between obese/severely obese (BMI > 30 kg/m 2 ) and normal weight controls (BMI 25 kg/m 2 ). Conclusions: We did not find any correlation between BMI and DAT availability in healthy volunteers.

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Reversal of dopamine system dysfunction in response to high‐fat diet

Carlin

Hill-Smith

Lucki

et al. 2013

Obesity

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ObjectiveTo test whether high fat diet (HFD) decreases dopaminergic tone in reward regions of the brain and evaluate whether these changes reverse after removal of the HFD.Design and MethodsMale and female mice were fed a 60% HFD for 12 weeks. An additional group was evaluated 4 weeks after removal of the HFD. These groups were compared to control fed, age-matched controls. Sucrose and saccharin preference was measured along with mRNA expression of dopamine related genes by RT-qPCR. Dopamine and DOPAC were measured using high performance liquid chromatography. DNA methylation of the DAT promoter was measured by methylated DNA immmunoprecipitation and RT-qPCR.ResultsAfter chronic HFD, sucrose preference was reduced, and then normalized after removal of the HFD. Decreased expression of dopamine genes, decreased dopamine content and alterations in DAT promoter methylation was observed. Importantly, response to HFD and the persistence of changes depended on sex and brain region.ConclusionsThese data identify diminished dopamine tone after early-life chronic HFD with a complex pattern of reversal and persistence that varies by both sex and brain region. CNS changes that did not reverse after HFD withdrawal may contribute to the difficulty in maintaining weight-loss after diet intervention.

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Correlation between body mass index and striatal dopamine transporter availability in healthy volunteers—A SPECT study

Cited by 91 publications

References 47 publications

Correlation between errors on the Wisconsin Card Sorting Test and the availability of striatal dopamine transporters in healthy volunteers

Correlation between errors on the Wisconsin Card Sorting Test and the availability of striatal dopamine transporters in healthy volunteers

No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [¹²³I]PE2I

Reversal of dopamine system dysfunction in response to high‐fat diet

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Correlation between body mass index and striatal dopamine transporter availability in healthy volunteers—A SPECT study

Cited by 91 publications

References 47 publications

Correlation between errors on the Wisconsin Card Sorting Test and the availability of striatal dopamine transporters in healthy volunteers

Correlation between errors on the Wisconsin Card Sorting Test and the availability of striatal dopamine transporters in healthy volunteers

No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [123I]PE2I

Reversal of dopamine system dysfunction in response to high‐fat diet

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Product

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No correlation between body mass index and striatal dopamine transporter availability in healthy volunteers using SPECT and [¹²³I]PE2I