Correlation between C-reactive protein and postoperative mortality in patients undergoing hip fracture surgery: a meta-analysis

Chen, Bing-Kuan; Liu, Yucheng; Chen, Chun-Ching; Chen, Yu‐Pin; Kuo, Yi-Jie; Huang, Shu-Wei

doi:10.1186/s13018-023-03516-y

Cited by 9 publications

(4 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In rat models, systemic inflammation has been shown to be aggravated by hip fracture in aged animals [ 7 ]. Consistently, clinical studies have also demonstrated that inflammatory biomarkers such as TNF-α, IL-6, IL-10, and CRP may play an important role in postoperative mortality in elderly hip fracture patients [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 84%

Predictive value of the systemic immune-inflammation index on one-year mortality in geriatric hip fractures

Çelen

2024

BMC Geriatr

View full text Add to dashboard Cite

Background Geriatric hip fractures are associated with a high incidence of mortality. This study examines the predictive value of the systemic immune-inflammation index (SII) on one-year mortality in elderly hip fracture patients. Methods A single-center retrospective study was conducted between February 2017 and October 2020. Three hundred and eleven surgically treated consecutive hip fracture patients were included in the study. Admission, postoperative first day, and postoperative fifth-day SII values were calculated. The receiver operating characteristic (ROC) curve was used to calculate the cut-off values, and patients were divided into high and low groups according to these cut-off values. After univariate Cox regression analysis, significant factors were included in the multivariate Cox proportional hazards model to adjust the effect of covariates and explore independent predictive factors associated with mortality. Further subgroup analysis was performed to evaluate the accuracy of the results for different clinical and biological characteristics. Results The mean age was 80.7 ± 8.0 years, and women made up the majority (67.8%) of the patients. The one-year mortality rate was 28.0%. After univariate and multivariate analyses, high postoperative fifth-day SII remained an independent predictor of one-year mortality (adjusted HR 2.16, 95% CI 1.38–3.38, p = 0.001). Older age, male gender, Charlson comorbidity index (CCI) ≥ 2, and hypoalbuminemia were found to be other independent predictors. The optimal cut-off value of the postoperative fifth-day SII was calculated at 1751.9 units (p < 0.001). Conclusion The postoperative fifth-day SII is a simple and useful inflammatory biomarker for predicting one-year mortality in patients with hip fracture.

show abstract

Section: Introductionmentioning

confidence: 84%

Predictive value of the systemic immune-inflammation index on one-year mortality in geriatric hip fractures

Çelen

2024

BMC Geriatr

View full text Add to dashboard Cite

show abstract

“…Given the projected global increase in hip fracture, addressing the substantial hip fracture-associated health risks of older adults is crucial (1). Numerous studies have identi ed a positive association between postoperative mortality and various in ammatory parameters related to hip fracture surgery, including RDW (11,(16)(17)(18)(19), NLR (6,11,16,20,21), PLR (16, 21-23), C-reactive protein level (24), albumin level (25), and total lymphocyte count (25). To date, no prospective study has compared single laboratory parameters as prognostic factors for the mortality risk associated with hip fracture.…”

Section: Discussionmentioning

confidence: 99%

Comparing the Prognostic Roles of Red Blood Cell Volume Distribution Width, Neutrophil–Lymphocyte Ratio, and Platelet–Lymphocyte Ratio for Predicting Mortality after Hip Fracture in the Geriatric Population

Su,

Huang,

Huang

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Background Hip fractures have adverse effects on older adults, often resulting in reduced functional independence, increased social costs, morbidity, and an elevated risk of mortality within 1 year after surgery. Prognostic markers such as red blood cell volume distribution width (RDW), the neutrophil–lymphocyte ratio (NLR), and the platelet–lymphocyte ratio (PLR) have been used to predict outcomes following hip fracture surgery; however, their prediction accuracy has varied across studies. This study aims to compare the prognostic accuracy of a single marker (RDW, NLR, or PLR) in predicting the mortality of older adults after hip fracture surgery. Methods This study enrolled 469 patients who underwent hip fracture surgery and were followed up for 1 year at a single tertiary medical center from December 2018 to March 2021. The patients’ preoperative RDW, NLR, and PLR levels were measured, and data on their clinical characteristics were collected. Receiver operating characteristic curves and areas under the curve (AUCs) were used to assess the predictive accuracy of these markers for 1-month, 3-month, and 1-year mortality. Results Among the patients, the mean age was 81.2 years, and 2.6%, 4.1%, and 13.9% died within 1 month, 3 months, and 1 year after surgery, respectively. RDW, NLR, and PLR were nonsignificant predictors of 1-month mortality, but RDW was the sole significant predictor of 3-month and 1-year mortality (AUC: 3-month, 0.689; 1-year, 0.583). The cutoff values for RDW were 15.05% and 13.65% for 3-month and 1-year mortality, respectively. Among the patients aged 60–80 years, RDW was a significant predictor of mortality following hip fracture surgery (AUC: 1-month, 0.834; 3-month, 0.855). However, for the patients aged > 80 years, all three markers were nonsignificant predictors. Conclusion RDW was a robust prognostic factor that outperformed NLR and PLR in predicting the mortality of patients aged > 60 years who underwent hip fracture surgery. Furthermore, the predictive accuracy of RDW was even higher for 1-month and 3-month mortality of patients aged 60–80 years who underwent hip fracture surgery.

show abstract

“…Studies have revealed a potential link between blood markers obtained via routine blood tests and hip fracture outcomes. Specifically, studies have reported that low hemoglobin, low albumin, high creatinine, and high C-reactive protein (CRP) were associated with a relatively high risk of death [ 9 , 10 ]. Moreover, red blood cell distribution width (RDW) has been identified as a probable predictor for mortality following hip fractures [ 11 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

The Association between Red Blood Cell Distribution Width and Mortality Risk after Hip Fracture: A Meta-Analysis

Nguyen,

Tran,

Nguyen

et al. 2024

Medicina

Self Cite

View full text Add to dashboard Cite

Background and Objectives: Hip fractures in the elderly pose a considerable health risk and cause concern. Red blood cell distribution width (RDW) is a valuable marker for identifying patients at high risk of age-related mortality and various disorders and diseases. However, its association with poor patient outcomes following hip fractures has yet to be fully established. Hence, the purpose of this meta-analysis was to investigate and gain a better understanding of the relationship between RDW levels and the risk of mortality after hip fractures. Materials and Methods: PubMed, Embase, Web of Science, and other databases were comprehensively searched until April 2023 to identify relevant studies. The meta-analysis included observational studies finding the association between RDW at admission or preoperation and short-term and long-term mortality rates following hip fractures. The results were presented in terms of odds ratios (ORs) or hazard ratios (HRs) with corresponding 95% confidence intervals (CIs). Results: This meta-analysis included 10 studies involving 5834 patients with hip fractures. Patients with preoperative RDW of over 14.5% had higher risks of 1-year (OR: 5.40, 95% CI: 1.89–15.48, p = 0.002) and 3-month (OR: 2.91, 95% CI: 1.42–5.95, p = 0.004) mortality. Higher admission or preoperative RDW was significantly associated with an 11% higher mortality risk after 1 year (HR: 1.11, 95% CI: 1.06–1.17, p < 0.00001). Patients with higher preoperative RDW had a significantly higher risk of 6-month mortality, which was three times that of those with lower preoperative RDW (OR: 3.00, 95% CI: 1.60–5.61, p = 0.0006). Higher preoperative RDW was correlated to a higher 30-day mortality risk (OR: 6.44, 95% CI: 3.32–12.47, p < 0.00001). Conclusions: Greater RDW values at admission or before surgery were associated with a higher risk of short-term and long-term mortality following hip fractures. Because RDW can be easily measured using a routine blood test at a low cost, this parameter is promising as an indicator of mortality in elderly patients with hip fractures.

show abstract

Correlation between C-reactive protein and postoperative mortality in patients undergoing hip fracture surgery: a meta-analysis

Cited by 9 publications

References 52 publications

Predictive value of the systemic immune-inflammation index on one-year mortality in geriatric hip fractures

Predictive value of the systemic immune-inflammation index on one-year mortality in geriatric hip fractures

Comparing the Prognostic Roles of Red Blood Cell Volume Distribution Width, Neutrophil–Lymphocyte Ratio, and Platelet–Lymphocyte Ratio for Predicting Mortality after Hip Fracture in the Geriatric Population

The Association between Red Blood Cell Distribution Width and Mortality Risk after Hip Fracture: A Meta-Analysis

Contact Info

Product

Resources

About