Correlation between cerebellar metabolism and post-stroke depression in patients with ischemic stroke

Abstract

The neurochemical changes that occur in the brain of patients with post-stroke depression (PSD) are not fully understood. This study aims to explore the correlation between cerebellar metabolism changes and PSD using proton magnetic resonance spectroscopy (1H-MRS). Participants were assigned to 3 groups: 60 patients with PSD (PSD group), 60 stroke patients without depression (NOPSD group), and 60 healthy volunteers (HEAL group). T1 WI, T2 WI, DWI and 1H-MRS examination were performed for patients at 14 days, 3 months after the stroke, respectively, and for healthy volunteers once when included in the study. Cho/Cr and Cho/NAA ratios in the cerebellar hemisphere contralateral to the lesion were higher in the PSD group than those in the HEAL and NOPSD groups on 14th day after the stroke (P < 0.05). In PSD group, Cho/Cr and Cho/NAA ratios in the cerebellar hemisphere contralateral to the lesion were positively correlated to the HAMD scale scores at both 14 days and 3 months after stroke (P < 0.05); Higher Cho/Cr and Cho/NAA ratios, and lower NAA/Cr ratio in the cerebellar hemisphere contralateral to the lesion were observed at 3 months after stroke compared to that at 14 days after stroke. Cerebellar damage may lead to PSD, and the degree of cerebellar damage may be associated with severity of PSD.

Long-Term Lower Limb Motor Function Correlates with Middle Cerebellar Peduncle Structural Integrity in Sub-Acute Stroke: A ROI-Based MRI Cohort Study

“…It mostly receives information from each cerebral lobe cortex, crosses to the opposite side and enters the cerebellum after pontine substitution. This anatomical structure is consistent with the CCD phenomenon observed secondary to supratentorial lesions of various etiologies [ 1 , 23 , 24 , 25 , 26 , 27 ]. However, there has been little discussion of MCP in the study of white matter integrity in stroke [ 28 , 29 ].…”

Impact of remote ischemic postconditioning on acute ischemic stroke in China: a systematic review and meta-analysis of randomized controlled trials

“…All included studies were categorized based on the duration of RIPostC implementation to enhance the reliability of our data analysis. This categorization included a 3-day group with 3 studies [59-61], a 7-day group comprising 9 studies [29, 35-37, 41, 42, 47, 58, 64], a 10-day group with 3 studies [44][45][46], a 14-day group consisting of 15 studies [4, 28, 31, 40, 48-53, 55-57, 60, 61], a 3-month group with 2 studies [30,38], and a 6-month group encompassing 6 studies [32-34, 39, 43, 54]. Detailed information and characteristics of the studies are listed in Tables 1 and 2.…”

Assessment of clinical manifestations and treatment of post-stroke depression in young patients with ischemic stroke

“…Особого внимания в связи с этим заслуживают нейрохимические изменения, которые происходят в церебральной ткани при ПД. Методом протонной магнитно-резонансной спектроскопии было установлено [15], что они существенно отличаются при наличии ПД и без таковой и более того -нейрохимические изменения в этим случаях зависят от тяжести депрессивного состояния.…”