Correlation between chlamydial infection and autoimmune response: molecular mimicry between RNA polymerase major σ subunit fromChlamydia trachomatis and human L7

Hemmerich, Peter; Neu, Elli; Macht, Marcus; Peter, Hans‐Hartmut; Krawinkel, Ulrich; Mikecz, Anna von

doi:10.1002/(sici)1521-4141(199811)28:11<3857::aid-immu3857>3.0.co;2-m

Cited by 18 publications

(4 citation statements)

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“…Autoimmune phenomena, particularly antinuclear antibodies and rheumatoid factor, have also been reported to occur in leprosy (59). A recent report indicated that a correlation exists between chlamydial infection and autoimmune response (60). The study showed evidence of molecular mimicry between an RNA polymerase major sigma subunit from Chlamydia trachomatis and one of the ribosomal proteins frequently targeted by autoantibodies in rheumatic diseases.…”

Section: Discussionmentioning

confidence: 99%

Antiphospholipid antibodies induced in mice by immunization with a cytomegalovirus‐derived peptide cause thrombosis and activation of endothelial cells in vivo

Gharavi

Pierangeli

Espinola

et al. 2002

Arthritis & Rheumatism

165

115

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Objective. To characterize the binding and functional properties of antiphospholipid antibodies (aPL) induced by immunization with a viral peptide and to determine whether aPL are pathogenic in vivo.Methods. Ten murine monoclonal aPL were generated from spleen cells of PL/J mice immunized with TIFI, a phospholipid-binding peptide spanning Thr 101 -Thr 120 of ULB0-HCMVA from human cytomegalovirus (CMV), which shares structural similarity with the phospholipid-binding site of ␤ 2 -glycoprotein I (␤ 2 GPI).Results. The antibodies generated had aPL activity that was inhibited by cardiolipin liposomes, and this inhibition was enhanced in the presence of ␤ 2 GPI. Some of the antibodies exhibited binding to cultured endothelial cells in vitro, and some had lupus anticoagulant activity. Injection with 2 of the monoclonal aPL in mice resulted in a significant increase in the number of leukocytes adhering to endothelial cells and enhanced thrombus formation in vivo.Conclusion. These results indicate that aPL induced by immunization with a phospholipid-binding CMV peptide are pathogenic in vivo. The results also suggest a mechanism (molecular mimicry) by which pathogenic aPL may be generated in patients with antiphospholipid syndrome.

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Section: Discussionmentioning

confidence: 99%

Antiphospholipid antibodies induced in mice by immunization with a cytomegalovirus‐derived peptide cause thrombosis and activation of endothelial cells in vivo

Gharavi

Pierangeli

Espinola

et al. 2002

Arthritis & Rheumatism

165

115

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“…While molecular mimicry between protein L7 and homologous region of Chlamydia trachomatis RNA was suggested, 174 association with Chlamydia sp. has been disproven.…”

Section: Exposures With Probable Association (Level III Evidence)mentioning

confidence: 99%

Toward Understanding of Environmental Risk Factors in Systemic Sclerosis

et al. 2020

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Importance Systemic sclerosis (SSc) is a severe, chronic, and incurable autoimmune fibrotic skin disease with significant extracutaneous involvement. Low concordance rate in twin studies and unequal geographic distribution of SSc argues for importance of environment in disease initiation and progression. Objective In this manuscript we provide a summary of all investigated potential external risk factors for SSc. Data sources A literature search in PubMed and EMBASE database was performed for studies published until January 1, 2020 by 2 reviewers (EN and LO) independently. Findings Occupational and/or environmental exposures to silica and organic solvents are associated with increased incidence and severity of SSc. Exposure to epoxy resins, asbestos, and particulate air pollution favors increased risk of SSc, but data are based on limited number of observational studies. There is insufficient evidence to conclude an association between SSc development and other occupational (eg, welding fumes) or personal exposures (eg, smoking, vitamin D deficiency). Association of SSc with silicone breast implants has been disproven. Infectious pathogens (eg, Helicobacter pylori and angiotropic viruses) and dysbiosis seem to play a role in SSc development and severity, but their role remains to be clarified. Conclusions and relevance It may be prudent to counsel our patients with SSc (or those at risk of SSc) to avoid occupations with exposure to silica, organic solvents, asbestos and epoxy resins; restraint from smoking, using cocaine or drugs with pro-fibrotic potential. While the association between low vitamin D and SSc remains to be confirmed, we believe that SSc patients should be encouraged to maintain healthy vitamin D levels as benefits outweigh the risks.

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“…Three ESTs encoding L3 ribosomal protein (Identities (I): 477 57 (82%), Expect Value (E): 6e‐24), L7A ribosomal protein (I: 51/ 86 (60%), E: 6e‐22), and histone H2A protein (I: 887 107 (82%), E: 3e‐42) showed high sequence similarity with their human counter parts. These proteins from other pathogenic organisms have already been implicated in the autoimmune response (Eriksen et al 1995; Hemmerich et al 1998). However, these Afu ESTs need further evaluation to establish their role in autoimmune reactions.…”

Section: Resultsmentioning

confidence: 99%

Identification and Assignment of Function to the Genes of Aspergillus fumigatus Expressed at 37 °C

Shankar

Nigam

Saxena

et al. 2004

J Eukaryotic Microbiology

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Aspergillus fumigatus, a fungal pathogen, causes a spectrum of allergic and invasive disorders. In order to rapidly identify genes of this fungus relevant for pathogenesis and as potential antifungal drug targets, 125 expressed sequence tags (ESTs) were generated from 200 phage clones of a non-normalized cDNA library. Out of a novel 68 ESTs, 45 were assigned putative functions based on the sequence similarity. The identities of some of these genes suggest that they may be involved in pathogenesis or autoimmune reactions. Additional genes were identified that are possible targets for the development of antifungal drugs or that may be of use in diagnosing fungal infections.

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Correlation between chlamydial infection and autoimmune response: molecular mimicry between RNA polymerase major σ subunit fromChlamydia trachomatis and human L7

Cited by 18 publications

References 50 publications

Antiphospholipid antibodies induced in mice by immunization with a cytomegalovirus‐derived peptide cause thrombosis and activation of endothelial cells in vivo

Antiphospholipid antibodies induced in mice by immunization with a cytomegalovirus‐derived peptide cause thrombosis and activation of endothelial cells in vivo

Toward Understanding of Environmental Risk Factors in Systemic Sclerosis

Identification and Assignment of Function to the Genes of Aspergillus fumigatus Expressed at 37 °C

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