Correlation between clinical indicators of lead poisoning and oxidative stress parameters in controls and lead-exposed workers

Gürer-Orhan, Hande; Sabır, Handan U; Özgüneş, Hilâl

doi:10.1016/j.tox.2003.09.009

Cited by 277 publications

(195 citation statements)

References 22 publications

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“…These results agree, in the literature review performed, with the studies published by numerous authors and refered in the Doctoral Thesis of González-López (1992) and others (Sakai, 2000;Gurer-Orhan et al, 2004). All of them showed the influence of Pb on the heme biosynthesis pathway and the effects produced in some of the enzymes which take part in the biosynthesis of porphyrins, phenomena demonstrated in clinical research, in vitro studies and in experiments on animals.…”

Section: Urinesupporting

confidence: 91%

Atomic Absorption Spectroscopy: Fundamentals and Applications in Medicine

Gonzalez-Lopez¹,

González-Romarís²,

Idoate-Cervantes³

et al. 2012

Macro to Nano Spectroscopy

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Section: Urinesupporting

confidence: 91%

Atomic Absorption Spectroscopy: Fundamentals and Applications in Medicine

Gonzalez-Lopez¹,

González-Romarís²,

Idoate-Cervantes³

et al. 2012

Macro to Nano Spectroscopy

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“…[33] In vitro and in vivo studies suggested that Pb-induced oxidative damage contributes to red blood cell damage. [34] This was supported by several human studies where the disrupted pro-oxidant/antioxidant balance was demonstrated in Pb-and/or Cd-exposed workers. [35,36] The importance of this pro-oxidant/antioxidant imbalance was, however, not completely clarified by means of correlating the oxidative damage endpoints with the clinical outcomes of Pb and/or Cd poisoning.…”

Section: Discussionmentioning

confidence: 71%

Evaluation of Toxic Metals in Blood and Urine Samples of Chronic Renal Failure Patients, before and after Dialysis

et al. 2008

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The determination of toxic elements in the biological samples of human beings is an important clinical screening procedure. The aim of this work was to determine total content of toxic elements-aluminum (Al), cadmium (Cd), and lead (Pb)-in whole blood and urine samples of male chronic renal failure patients (CRFPs) on maintenance hemodialysis from 2006 to 2007. The study included 100 CRFPs, plus 150 healthy volunteers in the control group. The concentration of toxic elements (TEs) were determined in blood sample before and after hemodialysis, while urine sample was determined once, before dialysis. Toxic elements were analyzed by electrothermal atomic absorption spectrometer, prior to microwave-induced acid digestion. The accuracy of the total Al, Cd, and Pb measurements was tested by simultaneously analyzing certified reference materials. No significant differences were established between the analytical results and the certified values (paired t-test at p > 0.05). The levels of TEs in blood samples of patients before dialysis were found to be higher than blood samples after dialysis session. In the control group, the blood levels of Al, Cd, and Pb were significantly lower than the chronic renal failure patients.Moreover, the study shows that analyzing levels of Al, Cd, and Pb may be useful in hemodialysis patients in evaluating TEs status.

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“…Inhibition of delta ALAD by Pb results in accumulation of delta ALA that can be rapidly oxidized to free radicals such as superoxide anion, hydroxyl radical and hydrogen peroxide [38]. Pb is also known to have the capacity to stimulate ferrous ion initiated membrane lipid peroxidation [39].…”

Section: Discussionmentioning

confidence: 99%