To investigate the loneliness of patients without family members who were hospitalized during the epidemic by using short video platform. A total of 350 inpatients without accompanying care in a Class ⅲ Grade A hospital in Shaanxi Province were investigated by loneliness scale, Use Intensity Scale and Use motivation scale. The use intensity had a partial mediating effect on the relationship between use motivation and loneliness in unaccompanied patients. The direct and indirect effects of motivation on loneliness were -0.512 and -0.343, respectively. As a social tool, short video can be used appropriately by patients without accompanying to expand social interaction and express themselves, which can satisfy their desire for entertainment, information acquisition and communication with others, and effectively reduce loneliness.