Correlation between cytokines and coagulation-related parameters in patients with coronavirus disease 2019 admitted to ICU

Zhang, Dong; Zhou, Xiang; Yan, Songxin; Tian, Ran; Su, Longxiang; Ding, Xin; Xiao, Meng; Chen, Yu; Zhao, Hua; Chen, Huan; Zhang, Hongmin; Li, Zunzhu; Li, Qi; Xu, Yingchun; Yan, Xiaowei; Li, Yongzhe; Zhang, Shuyang

doi:10.1016/j.cca.2020.07.002

Cited by 25 publications

(19 citation statements)

References 24 publications

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“…Some research has found that cytokines play an important role in the pathogenesis of COVID-19. Also, IL-6 seems more relevant in the evaluation of the condition of COVID-19 patients [23] . In addition to the core proteins such as IL-6 , which are involved in molecular docking simulation, the T-helper 1 cytokines ( IL1B, IFN-γ, IP10 , and MCP1 ) increase in patients infected by SARS-COV-2 [24] and other co-targeted genes such as IFNG and MAPK are also involved.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the mechanism of Shufeng Jiedu capsule prevention and treatment for COVID-19 by network pharmacology tools

Xiong

Dong

Lou

et al. 2020

European Journal of Integrative Medicine

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Introduction The novel coronavirus pneumonia that broke out in 2019 has become a global epidemic. According to the diagnosis and treatment plan issued in China and the existing clinical data, Shufeng Jiedu (SFJD) Capsule can be effectively used in the treatment of COVID-19 patients. This study aimed to explore its mechanism of action by network pharmacology and molecular docking technology. Methods The Chinese Medicine System Pharmacology Analysis Platform (TCMSP), a Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine (BATMAN-TCM), the Encyclopedia of Traditional Chinese Medicine (ETCM) and related literature records were used to search the composition and main active compounds of SFJD, and to screen out the targets of drug components. Disease-associated genes were obtained by the Human Gene Database (GeneCards), the Human Online Mendelian Inheritance Platform (OMIM) and the DisGeNET database, and the co-targeted genes/proteins as targets of both SFJD and COVID-19 were selected by the Comparative Toxicogenomics Database (CTD). Co-targeted genes/proteins were analyzed by STRING, the Database for Annotation, Visualization and Integrated Discovery (DAVID) and Reactome for proteins to protein interaction (PPI), pathway and GO (gene ontology) enrichment, and predicted by AutoDock for their high-precision docking simulation. In addition, the therapeutic effect for SFJD treatment on COVID-19 was validated by the Chinese medicine anti-novel coronavirus pneumonia drug effect prediction and analysis platform (TCMCOVID). Results Screening resulted in 163 compounds and 463 targeted genes. The PPI core network contains 76 co-targeted proteins. The Reactome pathways were enriched in signaling by interleukins, immune system, etc. Finally, 6 key proteins of TNF, IL-10, IL-2, IL-6, STAT1 and CCL2 were selected and successfully docked with 4 active ingredients of quercetin, luteolin, wogonin and kaempferol. Conclusion SFJD may play a role in the prevention and treatment of COVID-19 through multiple active compounds acting on multiple targets and then multiple pathways.

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Section: Discussionmentioning

confidence: 99%

Analysis of the mechanism of Shufeng Jiedu capsule prevention and treatment for COVID-19 by network pharmacology tools

Xiong

Dong

Lou

et al. 2020

European Journal of Integrative Medicine

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“…Resveratrol's ability to mitigate inflammation has also been suggested, owing to its suppressive action on interleukin 8 (IL-8), a circulating inflammatory cytokine. The relationship between increased proinflammatory cytokines and coagulopathy is intricate and has emerged as key player in the pathogenesis of COVID-19 [72]. Moreover, not only host factors have an impact on COVID-19-associated hemostatic disorders, but also specific viral proteins can significantly trigger the increase in pro-inflammatory cytokines, and consequently activation of the coagulation system [73].…”

Section: Resveratrol Modulates Thrombotic Markersmentioning

confidence: 99%

Therapeutic Potential of Resveratrol in COVID-19-Associated Hemostatic Disorders

et al. 2021

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Coagulation disorders, endotheliopathy and inflammation are the most common hallmarks in SARS-CoV-2 infection, largely determining COVID-19’s outcome and severity. Dysfunctions of endothelial cells and platelets are tightly linked in contributing to the systemic inflammatory response that appears to be both a cause and a consequence of COVID-19-associated coagulation disorders and thrombotic events. Indeed, elevated levels of circulating inflammatory cytokines are often associated with abnormal coagulation parameters in COVID-19 patients. Although treatments with low molecular weight heparin (LMWH) have shown beneficial effects in decreasing patient mortality with severe COVID-19, additional therapeutic strategies are urgently needed. Utilizing the anti-inflammatory and anti-thrombotic properties of natural compounds may provide alternative therapeutic approaches to prevent or reduce the risk factors associated with pre-existing conditions and comorbidities that can worsen COVID-19 patients’ outcomes. In this regard, resveratrol, a natural compound found in several plants and fruits such as grapes, blueberries and cranberries, may represent a promising coadjuvant for the prevention and treatment of COVID-19. By virtue of its anti-thrombotic and anti-inflammatory properties, resveratrol would be expected to lower COVID-19-associated mortality, which is well known to be increased by thrombosis and inflammation. This review analyzes and discusses resveratrol’s ability to modulate vascular hemostasis at different levels targeting both primary hemostasis (interfering with platelet activation and aggregation) and secondary hemostasis (modulating factors involved in coagulation cascade).

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“…An excessive inflammatory response to SARS-CoV-2 is considered to be the major cause of disease severity and the high fatality rate among COVID-19 patients [ 13 ] and is associated with high levels of circulating cytokines, vascular leakage, and immune cell infiltration in the lungs, heart, and kidney [ 16 , 20 , 21 , 22 ]. Inflammatory cytokines such as TNF-α, interferon gamma (IFN-γ), interleukin 6 (IL-6), and IL-10 present in the plasma of COVID-19 patients [ 23 , 24 ] induce mitochondrial reactive oxygen species production and impede mitochondrial oxidative phosphorylation and ATP production [ 25 , 26 ] among other effects. This, in turn, may lead to mitochondrial membrane permeabilization, cell death, and multiple organ dysfunction, a syndrome observed in COVID-19 patients [ 27 ].…”

Section: Sars-cov-2-induced Covid-19mentioning

confidence: 99%

Targeting the sAC-Dependent cAMP Pool to Prevent SARS-Cov-2 Infection

Aslam

Ladilov²

2020

Cells

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An outbreak of the novel coronavirus (CoV) SARS-CoV-2, the causative agent of COVID-19 respiratory disease, infected millions of people since the end of 2019, led to high-level morbidity and mortality and caused worldwide social and economic disruption. There are currently no antiviral drugs available with proven efficacy or vaccines for its prevention. An understanding of the underlying cellular mechanisms involved in virus replication is essential for repurposing the existing drugs and/or the discovery of new ones. Endocytosis is the important mechanism of entry of CoVs into host cells. Endosomal maturation followed by the fusion with lysosomes are crucial events in endocytosis. Late endosomes and lysosomes are characterized by their acidic pH, which is generated by a proton transporter V-ATPase and required for virus entry via endocytic pathway. The cytoplasmic cAMP pool produced by soluble adenylyl cyclase (sAC) promotes V-ATPase recruitment to endosomes/lysosomes and thus their acidification. In this review, we discuss targeting the sAC-specific cAMP pool as a potential strategy to impair the endocytic entry of the SARS-CoV-2 into the host cell. Furthermore, we consider the potential impact of sAC inhibition on CoV-induced disease via modulation of autophagy and apoptosis.

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Correlation between cytokines and coagulation-related parameters in patients with coronavirus disease 2019 admitted to ICU

Cited by 25 publications

References 24 publications

Analysis of the mechanism of Shufeng Jiedu capsule prevention and treatment for COVID-19 by network pharmacology tools

Analysis of the mechanism of Shufeng Jiedu capsule prevention and treatment for COVID-19 by network pharmacology tools

Therapeutic Potential of Resveratrol in COVID-19-Associated Hemostatic Disorders

Targeting the sAC-Dependent cAMP Pool to Prevent SARS-Cov-2 Infection

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