Correlation between cytoplasmic steroid receptors and tumour differentiation and invasion in endometrial carcinoma

Abstract

The incidence and levels of cytoplasmic steroid receptors were studied in 155 endometrial carcinomas: oestrogen receptors (ER) were measured in all samples. progesterone receptors (PR) in 148 and androgen receptors (AR) in 1 18. Well-differentiated adenocarcinomas were significantly more likely to contain ER, PR and AR than were poorlydifferentiated tumours, and mean values of ER and PR content were significantly higher in well-differentiated adenocarcinomas than in lessdifferentiated tumours. Receptor profiles in adenosquamous carcinomas and clear-cell carcinomas were similar to those in adenocarcinomas. Deeply invasive tumours were significantly less likely to be ER, PR or AR positive and, even when positive, such tumours had significantly lower mean levels of ER and PR. Poorly-differentiated tumours were significantly more likely to be ER-negative PR-positive than well-differentiated adenocarcinomas and adenosquamous carcinomas.

Estrogen and progesterone receptor content of enucleated uterine myomata after luteinizing hormone‐releasing hormone: Analogue depot therapy

“…Diminution of the 20 investigated fibroids showed a great variation, although E2 and P values were continuously and significantly suppressed to the postmenopausal range in all patients. This is in agreement with mor differentiation have been made by Quinn et al (21), who found that poorly differentiated endometrial adeno-and adenosquamous carcinomas are significantly more likely to be ER negative and PgR positive than comparable well differentiated neoplasms.…”

Estrogen and progesterone receptors in endometrial cancer Clinicopathological correlations and prognostic significance

“…In clear cell carcinoma, low incidences of ER andlor PR (Creasman et al 1985, Ehrlich et al 1988) and lower mean contents of both receptors yVyholm et al 1992/ZZ) have been found when compared to endometrioid adenocarcinoma. Similarly, in "adenosquamous" carcinoma, lower incidences and mean levels of one or both receptors than found in regular adenocarcinoma have been shown in four studies (Liao et al 1986, Chambers et al 1988, Ehrlich et al 1988, Nyholm et al 1992, while two studies reported receptor levels resembling those of adenocarcinoma (Creasman et al 1985, Quinn et al 1985a. In papillary serous carcinoma low receptor content has also been reported compared to adenocarcinoma (Creasman et al 1985, Chambers et al 1988).…”

“…1992/Il). Three of these studies reported a relationship between mean tumor receptor levels and invasion (Kauppila et al 1982a, Quinn et al 1985a, Chambers et al 1988).…”

“…In only three of the reports (Quinn et al 1985a, Chamberset al 1988, Nyholm et al 1992/Il) the relationship between histologic grade and invasion was taken into consideration. This is essential, since poorly differentiated tumors are likely to be more invasive than tumors of higher differentiation @inn 1988).…”