Correlation between decreased plasma miR-29a and vascular endothelial injury induced by hyperlipidemia

An, Li-Na; Gao, Liming; Ning, Min; Wu, Feng; Dong, Feifei; Ni, Xiushi; Wu, Yi‐Ying; Jing, Qing; Gao, Yanhong

doi:10.1007/s00059-022-05121-x

Cited by 5 publications

(3 citation statements)

References 33 publications

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“…Furthermore, obesogenic stimuli have been shown to dysregulate the expression of the miR-29 family. Depending on the tissue or cell type, HFD and saturated fatty acid exposure could either increase or decrease the levels of miR-29 family members [ 65 , 66 , 67 , 68 ].…”

Section: Discussionmentioning

confidence: 99%

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Bisphenol A Alters the Levels of miRNAs That Directly and/or Indirectly Target Neuropeptide Y in Murine Hypothalamic Neurons

Mak,

He,

Loganathan

et al. 2023

Genes

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The hypothalamus is a vital regulator of energy homeostasis. Orexigenic neuropeptide Y (NPY) neurons within the hypothalamus can stimulate feeding and suppress energy expenditure, and dysregulation of these neurons may contribute to obesity. We previously reported that bisphenol A (BPA), an endocrine disruptor with obesogenic properties, alters Npy transcription in hypothalamic neurons by inducing oxidative stress. We hypothesized that hypothalamic microRNAs (miRNAs), a class of small non-coding RNAs, could directly regulate Npy gene expression by binding the 3′ untranslated region (UTR). Five predicted Npy-targeting miRNA candidates were uncovered through TargetScan and were detected in Npy-expressing hypothalamic neuronal cell models and hypothalamic neuronal primary cultures. BPA dysregulated the expression of a number of these hypothalamic miRNAs. We examined the effects of putative Npy-targeting miRNAs using miRNA mimics, and we found that miR-143-3p, miR-140-5p, miR-29b-1-5p, and let-7b-3p altered Npy expression in the murine hypothalamic cell lines. Importantly, miR-143-3p targets the mouse Npy 3′ UTR, as detected using a luciferase construct containing the potential 3′ UTR binding sites. Overall, this study established the first hypothalamic miRNA that directly targets the 3′ UTR of mouse Npy, emphasizing the involvement of miRNAs in the NPY system and providing an alternative target for control of NPY levels.

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Section: Discussionmentioning

confidence: 99%

“…Depending on the tissue or cell type, HFD and saturated fatty acid exposure could either increase or decrease the levels of miR-29 family members [65][66][67][68].…”

Section: Discussionmentioning

confidence: 99%

Bisphenol A Alters the Levels of miRNAs That Directly and/or Indirectly Target Neuropeptide Y in Murine Hypothalamic Neurons

Mak,

He,

Loganathan

et al. 2023

Genes

View full text Add to dashboard Cite

show abstract

“…When hyperlipidemia occurs, elevated levels of lipids in the bloodstream can result in endothelial injury and inflammation, causing cardiovascular diseases. 56,57 As tissues with high metabolic rates, tendons also require sufficient blood supplies providing them with oxygen and nutrients. However, when the body is hyperlipidemic, the accumulation of cholesterol byproducts can impair proper blood circulation to tendons (Figure 1).…”

Section: Effect Of Hyperlipidemia On Tendon Diseasementioning

confidence: 99%

Metabolic Syndrome and Tendon Disease: A Comprehensive Review

Lai,

Li,

Tang

et al. 2024

DMSO

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Metabolic syndrome (MS) is a multifaceted pathological condition characterized by the atypical accumulation of various metabolic components such as central obesity or excess weight, hyperlipidemia, low-density lipoprotein (LDL), hypertension, and insulin resistance. Recently, MS has been recognized as a notable contributor to heart and circulatory diseases. In addition, with increasing research, the impact of MS on tendon repair and disease has gradually emerged. Recent studies have investigated the relationship between tendon healing and diseases such as diabetes, dyslipidemia, obesity, and other metabolic disorders. However, diabetes mellitus (DM), hypercholesterolemia, obesity, and various metabolic disorders often coexist and together constitute MS. At present, insulin resistance is considered the major pathological mechanism underlying MS, central obesity is regarded as the predominant factor responsible for it, and dyslipidemia and other metabolic diseases are known as secondary contributors to MS. This review aims to evaluate the current literature regarding the impact of various pathological conditions in MS on tendon recovery and illness, and to present a comprehensive overview of the effects of MS on tendon recovery and diseases, along with the accompanying molecular mechanisms.

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Identification of Oxidative Stress-Related Genes in Hyperlipidemia Based on Bioinformatic Analysis

Wang,

Hao,

Sun

et al. 2024

Mol Biotechnol

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Correlation between decreased plasma miR-29a and vascular endothelial injury induced by hyperlipidemia

Cited by 5 publications

References 33 publications

Bisphenol A Alters the Levels of miRNAs That Directly and/or Indirectly Target Neuropeptide Y in Murine Hypothalamic Neurons

Bisphenol A Alters the Levels of miRNAs That Directly and/or Indirectly Target Neuropeptide Y in Murine Hypothalamic Neurons

Metabolic Syndrome and Tendon Disease: A Comprehensive Review

Identification of Oxidative Stress-Related Genes in Hyperlipidemia Based on Bioinformatic Analysis

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