Correlation Between Exposure to Transfluthrin and the Change in Dielectric Properties and Deformed Cells of Mice

Abstract

Transflutrhin is a single isomer compound that is contained in mosquito repellent. The volatility of this chemical compound made it suited for applications that evaporate this active ingredient like space spray using one push mosquito repellent. As an aerosol, transfluthrin can trigger oxidative stress that causes cell damage. Cell damage can be identified microscopically or by analyzing the electrical characteristics of the cell. Cell damage due to the content of chemical compounds in the pollutants that enter the body will affect the electrical properties of the cell itself. One of the bio-electric variables in organ tissues that can be analyzed and used to determine the level of tissue damage is a change in the dielectric constant value of an organ. The measurement of the dielectric constant is done by using two conductor plates in which the dielectric material is inserted in the middle of the plates, and the capacitance value will be measured. The results show that a higher level of damage to the organ caused a lower dielectric constant value. This decrease was caused by the changes in the polarization properties of the damaged tissue. Factors that affected the polarization of material were large electric dipole moments and large numbers of healthy and damaged cells. Organ damage was determined based on the decrease in the value of dielectric constant. Histological studies revealed severe cell damages evidenced by the deformed cell compared to the unexposed mice. Type-A mosquito repellents with transfluthrin active ingredients of 25% caused 74% at lung cell damage, 71% of blood damage, 47% of kidney cell damage, and 40% of liver cell damage, with dielectric organ constants 0.65x10 5 to 2.62x10 5. In the mice exposed to type-B mosquito repellent (21.3% of transfluthrin), the damage levels were 72%, 72%, 49%, and 36%, respectively, for lung, blood, kidney, and liver cells. The dielectric constants were 0.91x10 5 to 2.62x10 5. Our studies indicate that mosquito repellent aerosol does initiate physical damage