Correlation Between Expression of Cell Adhesion Molecules CD₄₄v6 and E-cadherin and Lymphatic Metastasis in Non-small Cell Lung Cancer

Abstract

Objective: To explore the relationship between expressions of cell adhesion molecules CD44 v6 and E-cadherin (E-cad) and lymphatic metastasis in non-small cell lung cancer (NSCLC). Materials and Methods: Eightyseven tissue samples obtained from patients with primary NSCLC were collected in our hospital from Dec., 2007 to Dec., 2012, and the expressions of CD44 v6 and E-cad gene proteins in these samples were detected by immunohistochemical method. Results: In the tissue without lymphatic metastasis, the positive expression rate of CD44 v6 was significantly lower, whereas the normal expression rate of E-cad was notably higher than that with lymphatic metastasis (55.6% vs. 78.4%, 47.2% vs. 21.6%), and both differences had statistical significance (P<0.05). Besides, CD44 v6 and E-cad expressions had a significant correlation in the NSCLC tissue with lymphatic metastasis (P<0.05). Conclusions: The positive expression of CD44 v6 and abnormal expression of E-cad may play a very important role in promoting lymphatic metastasis of NSCLC, with synergistic effect. Hence, detection of CD44 v6 and E-cad expressions is conductive to judging the lymphatic metastasis in NSCLC.

Prognostic Value of CD44 Variant exon 6 Expression in Non-Small Cell Lung Cancer: a Meta-analysis

“…Study by Sun et al elucidated that CD44v6 might be correlated with the histogenesis of NSCLC, and decreased CD44v6 expression was an adverse prognostic indicator for squamous cell carcinoma rather than adenocarcinoma or bronchioalveolar carcinoma (Sun et al, 2013). Another study found the positive expression rate of CD44v6 was significantly lower in the NSCLC tissue without lymphatic metastasis, which was accordant with our results, and detection of CD44v6 expression could be used to judge the lymphatic metastasis in NSCLC (Su et al, 2014). The mechanism of CD44v6 promoting the metastasis of cancer may be attributed to its interactions with various components of the extracellular matrix, and its involvement in cell adhesion and critical signaling pathways.…”

Correlation between E-Cadherin-Regulated Cell Adhesion and Human Osteosarcoma MG-63 Cell Anoikis

“…Changes in the expression of adhesion proteins can affect downstream signaling cascades and enhance cellular survival. Many tumor cells can switch on/off the expression of adhesion molecules so that they express the correct adhesion molecules in different microenvironments, thus preventing the induction of cellular death (Su et al, 2014). In this study, EDTA was used to block intercellular adhesion and osteosarcoma anoikis was found to increase.…”

Low Expression of the FoxO4 Gene may Contribute to the Phenomenon of EMT in Non-small Cell Lung Cancer

“…E-cadherin was significantly related to the degree of EMT and tumor malignancy, for example in lung cancer (Bremnes et al, 2002), gastric cancer (JooRewChoi et al, 2002), skin cancer (McGary et al, 2002), breast cancer (BerxVan Roy 2001), pancreatic cancer (JooRewPark et al, 2002) and nasopharyhgeal cancer (Tsao et al, 2003). Recently, studies have demonstrated that the positive expression rate of E-cadherin in NSCLC tissue without lymphatic metastasis was significantly higher than that with lymphatic metastasis (47.2% vs. 21.6%) (Su et al, 2014). Earlier studies showed that expression of E-cadherin was associated with the patients' survival in NSCLC (Wang et al, 2011).…”

“…Through metastasis, NSCLC cells are easily found in the bone, adrenal glands, liver, brain and regional lymph nodes (Tsao et al, 2003). Recently, studies have demonstrated that the positive expression rate of E-cadherin in NSCLC tissue without lymphatic metastasis was significantly higher than that with lymphatic metastasis (47.2% vs. 21.6%) (Su et al, 2014). Earlier studies showed that expression of E-cadherin was associated with the patients' survival in NSCLC (Wang et al, 2011).…”