Correlation between expression of MMP-9 and MMP-3 in Helicobacter pylori infected patients with different gastroduodenal diseases

Bagheri, Nader; Sadeghiani, Marzieh; Rahimian, Ghorbanali; Mahsa, Majid; Shafigh, Mohammedhadi; Rafieian-Kopaei, Mahmoud; Shirzad, Hedayatollah

doi:10.1016/j.ajg.2018.11.001

Cited by 12 publications

(8 citation statements)

References 38 publications

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“…MMP9 and MMP2 accelerate tumor metastasis by invading lymphatic vessels and small vessels [ 72 , 73 ]. On one hand, helicobacter pylori infection might enhance the expression of MMPs, induce cell proliferation, and activate gene oncogenes [ 74 , 75 ]. On the other hand, MMP9 and MMP2 could degrade type IV collagen in the extracellular matrix and basement membranes.…”

Section: Discussionmentioning

confidence: 99%

Comparison between Heat-Clearing Medicine and Antirheumatic Medicine in Treatment of Gastric Cancer Based on Network Pharmacology, Molecular Docking, and Tumor Immune Infiltration Analysis

Kang

Wang³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Clinical research found that TCM is therapeutic in treating gastric cancer. Clearing heat is the most common method, while some antirheumatic medicines are widely used in treatment as well. To explore the pharmacological mechanism, we researched the comparison between heat-clearing medicine and antirheumatic medicine in treating gastric cancer. Methods. First, related ingredients and targets were searched, respectively, and are shown in an active ingredient-target network. Combining the relevant targets of gastric cancer, we constructed a PPI network and MCODE network. Then, GO and KEGG enrichment analyses were conducted. Molecular docking experiments were performed to verify the affinity of targets and ligands. Finally, we analyzed the tumor immune infiltration on gene expression, somatic CNA, and clinical outcome. Results. A total of 31 ingredients and 90 targets of heat-clearing medicine, 31 ingredients and 186 targets of antirheumatic medicine, and 12,155 targets of gastric cancer were collected. Antirheumatic medicine ranked the top in all the enrichment analyses. In the KEGG pathway, both types of medicines were related to pathways in cancer. In the KEGG map, AR, MMP2, ERBB2, and TP53 were the most crucial targets. Key targets and ligands were docked with low binding energy. Analysis of tumor immune infiltration showed that the expressions of AR and ERBB2 were correlated with the abundance of immune infiltration and made a difference in clinical outcomes. Conclusions. Quercetin is an important ingredient in both heat-clearing medicine and antirheumatic medicine. AR signaling pathway exists in both types of medicines. The mechanism of the antitumor effect in antirheumatic medicine was similar to trastuzumab, a targeted drug aimed at ERBB2. Both types of medicines were significant in tumor immune infiltration. The immunology of gastric tumor deserves further research.

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Section: Discussionmentioning

confidence: 99%

Comparison between Heat-Clearing Medicine and Antirheumatic Medicine in Treatment of Gastric Cancer Based on Network Pharmacology, Molecular Docking, and Tumor Immune Infiltration Analysis

Kang

Wang³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Accumulated evidence has indicated that H. pylori-associated gastritis and gastric and duodenal ulcers are closely associated with cleaving and remodeling of the ECM by MMPs (21)(22)(23)(24). Previous studies using patient biopsies have indicated a dramatic elevation in MMP-2 and MMP-9 expressions upon H. pylori infections (25,26). In this study, similar to previous reports, we discovered lower MMP-2 and MMP-9 expressions in the H. pylori eradication group than in the H. pylori infection group.…”

Section: Discussionmentioning

confidence: 99%

Adhesin HpaA of Helicobacter pylori Promoted Migration of AGS Cells via IL-21 Secretion from HpaA-induced CD4+T Cells

Xia

Hua

et al. 2020

Jundishapur J Microbiol

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Background: As known, there is a high correlation between Helicobacter pylori infection and gastric carcinoma. Objectives: Concerning the important role of adhesin HpaA of H. pylori in the infection process, we aimed to explore whether HpaA promotes gastric cancer metastasis. Methods: In this study, the levels of IL-21, MMP-2, and MMP-9 in patients’ biopsies with H. pylori infection were compared with post-treatment condition. The levels of IL-21 from CD4+ T cells and culture supernatants with the recombinant HpaA treatment were detected, and then the levels of MMP-2, MMP-9, and metastasis were detected and verified via AGS cells co-cultured with aforesaid CD4+ T cells. Results: Our results showed that higher levels of IL-21, MMP-2, and MMP-9 in patients’ biopsies with H. pylori infection than without H.pylori infection. Adhesin HpaA induced more IL-21 via CD4+ T cells, and IL-21 induced high MMP-2 and MMP-9 via AGS cells. In particular, HpaA caused this serial reaction to improve the migration of AGS cells, and aptamer HA6 (our previous report) and anti-IL-21 mcAb reduced the above phenomenon remarkably. Conclusions: In summary, our research suggested that adhesin HpaA plays a significant role in the process of gastric carcinoma cell metastasis via IL-21 from HpaA-induced T cells, and aptamer HA6 may be a potential therapeutic agent for H. pylori treatment.

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“…IHC has shown that H. pylori-related gastric ulcers express significantly higher levels of MMP-7, MMP-9 and TIMP-1 in comparison to undamaged tissue and NSAID (nonsteroidal antiinflammatory drug)-related ulcer tissue [69]. The upregulation of MMP-7 in peptic ulcer was related to the cagPAI-and CagA-expressing H. pylori [46,70]. The MMP-9 and TIMP-1 levels in ulcers were higher than in the chronic superficial gastritis specimens [41].…”

Section: Mmps In Ulcermentioning

confidence: 99%

Matrix Metalloproteinases in Helicobacter pylori–Associated Gastritis and Gastric Cancer

Sokolova

Naumann

2022

IJMS

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Gastric cancer is one of the leading causes of the cancer-related mortality worldwide. The etiology of this disease is complex and involves genetic predisposition and environmental factors, including Helicobacter pylori. Infection of the stomach with H. pylori leads to gastritis and gastric atrophy, which can progress stepwise to gastric cancer. Matrix metalloproteinases (MMPs) actively participate in the pathology development. The further progression of gastric cancer seems to be less dependent on bacteria but of intra-tumor cell dynamics. Bioinformatics data confirmed an important role of the extracellular matrix constituents and specific MMPs in stomach carcinoma invasion and metastasis, and revised their potential as predictors of the disease outcome. In this review, we describe, in detail, the impact of MMPs in H. pylori–associated gastritis and gastric cancer.

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Correlation between expression of MMP-9 and MMP-3 in Helicobacter pylori infected patients with different gastroduodenal diseases

Cited by 12 publications

References 38 publications

Comparison between Heat-Clearing Medicine and Antirheumatic Medicine in Treatment of Gastric Cancer Based on Network Pharmacology, Molecular Docking, and Tumor Immune Infiltration Analysis

Comparison between Heat-Clearing Medicine and Antirheumatic Medicine in Treatment of Gastric Cancer Based on Network Pharmacology, Molecular Docking, and Tumor Immune Infiltration Analysis

Adhesin HpaA of Helicobacter pylori Promoted Migration of AGS Cells via IL-21 Secretion from HpaA-induced CD4+T Cells

Matrix Metalloproteinases in Helicobacter pylori–Associated Gastritis and Gastric Cancer

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