Correlation between fungi isolated from burn wounds and burn care units

Mousa, Haider Abdul-Lateef; Al-Bader, Salah M.; Hassan, Dina A.

doi:10.1016/s0305-4179(98)00148-x

Cited by 27 publications

(18 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thermally injured children are at particular risk for fungal infections involving the burn wound (262). Such infections usually occur after the second week of thermal injury, usually following a period of burn wound colonization with fungi found in the surrounding environment and/or, in the case of Candida spp., from the patient's own gastrointestinal or upper respiratory tract flora (37,63,301,303).…”

Section: Other Types Of Infectionmentioning

confidence: 99%

“…Aggressive wide surgical excision of the infected areas of the burn wound before the development of deep invasion, combined with systemic antifungal agents, may lead to an improved chance of survival (65,105,141,424). The use of a laminar-airflow isolation room, in conjunction with optimal local wound care, appears to decrease the incidence of both disseminated and local fungal infection (103,303). Topical prophylaxis with an antifungal cream such as clotrimazole or nystatin may lead to a reduced incidence of burn wound infections and septicemia (31,189,192).…”

Section: Other Types Of Infectionmentioning

confidence: 99%

See 1 more Smart Citation

Burn Wound Infections

Church

Elsayed

Reid³

et al. 2006

Clin Microbiol Rev

1,623

1,345

View full text Add to dashboard Cite

SUMMARYBurns are one of the most common and devastating forms of trauma. Patients with serious thermal injury require immediate specialized care in order to minimize morbidity and mortality. Significant thermal injuries induce a state of immunosuppression that predisposes burn patients to infectious complications. A current summary of the classifications of burn wound infections, including their diagnosis, treatment, and prevention, is given. Early excision of the eschar has substantially decreased the incidence of invasive burn wound infection and secondary sepsis, but most deaths in severely burn-injured patients are still due to burn wound sepsis or complications due to inhalation injury. Burn patients are also at risk for developing sepsis secondary to pneumonia, catheter-related infections, and suppurative thrombophlebitis. The introduction of silver-impregnated devices (e.g., central lines and Foley urinary catheters) may reduce the incidence of nosocomial infections due to prolonged placement of these devices. Improved outcomes for severely burned patients have been attributed to medical advances in fluid resuscitation, nutritional support, pulmonary and burn wound care, and infection control practices.

show abstract

Section: Other Types Of Infectionmentioning

confidence: 99%

Section: Other Types Of Infectionmentioning

confidence: 99%

Burn Wound Infections

Church

Elsayed

Reid³

et al. 2006

Clin Microbiol Rev

1,623

1,345

View full text Add to dashboard Cite

show abstract

“…The same organisms cultured from burn patients, including Aspergillus, Penicillium, and Zygomycetes spp., are more frequently in the burn unit than in other areas of a hospital [56], emphasizing the importance of strict infection control procedures.…”

Section: Fungal Infectionsmentioning

confidence: 99%

Emerging Infections in Burns

Branski

Al-Mousawi

Rivero

et al. 2009

Surgical Infections

294

174

View full text Add to dashboard Cite

Background: Patients who suffer severe burns are at higher risk for local and systemic infections. In recent years, emerging resistant pathogens have forced burn care providers world wide to search for alternative forms of treatment. Multidrug-resistant Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter spp., and various fungal strains have been the major contributors to the increase in morbidity and mortality rates. Multi-drugresistant S. aureus remains the major cause of gram-positive burn wound infections world wide. Treatment strategies include rigorous isolation protocols and new types of antibiotics where necessary. Methods: We reviewed 398 severely burned patients (burns >40% total body surface area [TBSA]) admitted to our hospital between 2000 and 2006. Patients who did not contract multi-drug-resistant gram-negative organisms during their hospital course and received our standard antibiotic regimen-vancomycin and piperacillin= tazobactam-served as controls (piperacillin=tazobactam; n ¼ 280). The treatment group consisted of patients who, during their acute hospital stay, developed infections with multi-drug-resistant gram-negative pathogens and were treated with vancomycin and colistin for at least three days (colistin; n ¼ 118). Results: Gram-negative organisms continue to cause the most severe infections in burn patients. Colistin has reemerged as a highly effective antibiotic against multiresistant Pseudomonas and Acinetobacter infections of burns. Patients who required colistin therapy had a significantly larger average total and full-thickness burn than patients treated with piperacillin=tazobactam and vancomycin, and the mortality rate was significantly higher in the colistin group (p < 0.05). However, there was no significant difference between the colistin and piperacillin= tazobactam groups in the incidence of neurotoxicity, hepatic toxicity, or nephrotoxicity. The main fungal pathogens in burn patients are Candida spp., Aspergillus spp., and Fusarium spp. A definitive diagnosis is more difficult to obtain than in bacterial infections. Amphotericin B and voriconazole remain the two most important anti-fungal substances in our practice. Conclusions: Innovations in fluid management, ventilatory support, surgical care, and antimicrobial therapy have contributed to a significant reduction in morbidity and mortality rates in burn patients. Vancomycin and clindamycin are the two most important reserve antibiotics for methicillin-resistant Staphylococcus aureus infection. Oxazolidinones and streptogramins have showed high effectiveness against gram-positive infections. Colistin has re-emerged as a highly effective antibiotic against multiresistant Pseudomonas and Acinetobacter infections. Current challenges include Candida, Aspergillus, and molds. The development of new agents, prudent and appropriate use of antibiotics, and better infection control protocols are paramount in the ongoing battle against multi-resistant organisms.

show abstract

“…Devido à imaturidade do sistema imune do recém-nascido e ao uso de antibioticoterapia de largo espectro, fungos comumente encontrados no ar podem se tornar patógenos (1)(2)(3) . Nas imunodeficiências, em crianças mais velhas, também se criam condições para numerosas infecções por fungos (4)(5)(6) . Desta forma, assume grande importância o estudo dos fungos oportunistas, especialmente em ambiente hospitalar.…”

Section: Introductionunclassified

Flora fúngica no ambiente da Unidade de Terapia Intensiva Pediátrica e Neonatal em hospital terciário

Melo

Lima

Damasceno

et al. 2009

Rev. paul. pediatr.

View full text Add to dashboard Cite

RESUMOObjetivo: As infecções nosocomiais são responsáveis por morbidade e mortalidade significativas no período neonatal. Considerando-se a preocupação com a qualidade do ar de áreas críticas como Unidades de Terapia Intensiva (UTI), foi realizado um levantamento da flora fúngica das UTI Pediátrica e Neonatal do Hospital das Clínicas Samuel Libânio, Pouso Alegre (MG), com a finalidade de identificar a presença de fungos potencialmente patogênicos e oportunistas.Métodos: Foram realizadas 30 coletas, que incluíram leitos, incubadoras, janelas, aparelhos de ar condicionado, telefone, estetoscópios, portas e maçanetas. Placas de Agar Sabouraud Dextrose com o material das coletas foram incubadas em temperatura ambiente por 15 dias. A identificação foi baseada nas características macroscópicas no exame direto e em microcultivos.Resultados: Fungos potencialmente patogênicos e toxigênicos foram isolados. A análise quantitativa das colônias revelou a presença de 11 gêneros. Verificou-se que mais de 40% das colônias correspondem ao gênero Penicillium spp, seguido por Cladosporium spp e Chrysosporium spp.Conclusões: Os fungos encontrados podem apresentar grande potencial de patogenicidade, principalmente em imunodeprimidos. É importante adotar medidas de controle ambiental, como assepsia dos equipamentos, controle da presença de visitantes, lavagem das mãos pelos funcionários e troca de filtros de ar condicionado.Palavras-chave: fungos; infecção hospitalar; infecções fúngicas; unidades de terapia intensiva pediátrica; unidades de terapia intensiva neonatal.Endereço para correspondência:

show abstract

Correlation between fungi isolated from burn wounds and burn care units

Cited by 27 publications

References 5 publications

Burn Wound Infections

Burn Wound Infections

Emerging Infections in Burns

Flora fúngica no ambiente da Unidade de Terapia Intensiva Pediátrica e Neonatal em hospital terciário

Contact Info

Product

Resources

About