Correlation between Gensini Score and Duration of Diabetes in Patients Undergoing Coronary Angiography

Abstract

Introduction The relationship between the duration of diabetes mellitus and coronary artery disease (CAD) is well established. Moreover, the Gensini score system is a reliable assessment tool for the severity of coronary artery disease (CAD). After an extensive literature search, we found that there is a knowledge gap about the relationship between the Gensini score and the duration of diabetes in our population. Therefore, the aim of this study was to find the relationship between the Gensini score and the duration of diabetes in patients undergoing a coronary angiography. Methods A cross-sectional study was conducted among 321 consecutively selected diabetic patients. Clinically diagnosed cases of diabetes on proper anti-diabetic treatment were included in this study. Patients with known severe CAD or history of coronary artery bypass grafting (CABG) surgery or primary coronary intervention (PCI) were excluded from the study. Coronary angiography was performed on all the patients and their Gensini score was calculated using the modified scoring schema. Duration of diabetes and other baseline risk factors were recorded for all patients. The relationship between the Gensini score and the duration of diabetes was assessed by calculating Pearson’s correlation coefficient. Results A total of 321 diabetic patients were included in this study, out of which 67.9% (218) were men and mean ± standard deviation age was 56.13 ± 7.67 years ranging between 40 to 70 years with a majority of the patients, 63.9% (205), being under 60 years of age. Along with diabetes, the most commonly observed risk factor was hypertension, which was observed in 77.6% (249) of the patients. Smoking and obesity were also observed in 18.7% (60) and 17.4% (56) of the patients, respectively. A significant positive correlation, 0.55 (p<0.001), was observed between the duration of diabetes and the Gensini scores. The correlation was found to be stronger in older patients (more than 60 years of age) with a correlation coefficient of 0.52 vs. 0.38, and male patients with correlation coefficients of 0.66 vs. 0.34. Conclusion A significant positive correlation between the Gensini score and the duration of diabetes mellitus was observed. This correlation is relatively stronger among male and older patients (more than 60 years of age).

Gensini Score as a Predictor for in-Stent Restenosis in Patients with Coronary Artery Disease (CAD)

“…In contrast to other available ISR risk strati cation tools, the Gensini score is a reliable and easily calculated scoring tool and therefore may be applied in daily practice to predict ISR with DES. The Gensini score was originally intended to quantify the severity of CAD, Razi et al [26] found a signi cant positive correlation between Gensini score and the duration of diabetes. However, subsequent studies have shown that it is able to identify patients at high risk of adverse events treated with PCI [27,28].…”

Relationship between serum cystatin-c and coronary lesion severity in coronary artery disease patients with a normal glomerular filtration rate

“…The Gensini score was used to evaluate the severity of atherosclerosis as described previously. 21 , 22 …”

“…The Gensini score was used to evaluate the severity of atherosclerosis as described previously. 21,22 Statistical analysis SPSS Statistics for Windows, Version 17.0 (SPSS Inc., Chicago, IL, USA) was used for statistical analysis. Measurement data were presented as the mean AE standard deviation or median (inter-quartile range).…”

Clinical and procedural characteristics of persons living with HIV presenting with acute coronary syndrome

“…The Gensini score attempts to quantify the functional significance of a patient's coronary atherosclerotic burden by incorporating a point system for the degree of vessel luminal narrowing that accounts for the specific anatomic location of the stenosis [15]. It is strongly correlated with coronary plaque burden, plaque area, and prognosis [16], and correlates with the duration of other traditional cardiovascular risk factors including smoking [17] and diabetes [18]. However, to our knowledge, only one prior study examined Gensini scores among PLWH presenting with ACS [19].…”