Correlation between glucose fluctuations and carotid intima-media thickness in type 2 diabetes

Chen, Xiaomin; Zhang, Yan; Shen, Xingping; Qun, Huang; Ma, Hong; Huang, Yang-Ling; Zhang, Wenqiang; Wu, Hongxun

doi:10.1016/j.diabres.2010.05.004

Cited by 33 publications

(21 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The strong links with type two diabetes demonstrated similar plausibility. Associations between CIMT, and type two diabetes are well established [36]. However, we failed to demonstrate a link between the lipoprotein subfractions and CIMT.…”

Section: Discussioncontrasting

confidence: 71%

Atherogenic subfractions of lipoproteins in the treatment of metabolic syndrome by physical activity and diet – the RESOLVE trial

Dutheil

Walther²,

Chapier

et al. 2014

Lipids Health Dis

View full text Add to dashboard Cite

BackgroundWe aimed to comprehensively evaluate lipoprotein profile including lipid particle size following a lifestyle intervention in metabolic syndrome (MetS) volunteers and to assess the associations between lipoprotein subfractions and carotid-intima-media-thickness (CIMT) – a surrogate indicator of atherogenesis.Methods100 participants (50–70 years) from the RESOLVE trial, underwent a one-year follow-up beginning with a three-week residential program combining high exercise volume (15-20 h/week), restrictive diet (-500 kcal/day), and education. For baseline references, 40 aged-matched healthy controls were recruited. Independent associations between subfractions of lipoproteins and CIMT were evaluated using a generalized estimating equations model accounting for variation in correlations between repeated measures. The lipoprotein subfractions profile was assessed using Lipoprint® electrophoresis allowing to separate: the very low-density lipoprotein (VLDL) fraction, then the intermediate-density lipoprotein (IDL) C, B and A, the low-density lipoprotein (LDL) with subfractions 1 and 2 as large LDL and subfractions 3 to 7 as small dense LDL (sdLDL), and the high density lipoprotein (HDL) subfractions categorized into large, intermediate, and small HDL. Apolipoproteins A1 and B were also measured.Results78 participants completed the program. At baseline, apolipoproteins B/A1, VLDL, sdLDL and small HDL were higher in MetS than in healthy controls; IDL, LDL size, large and intermediate HDL were lower. Despite time-related regains during the follow-up, lipoprotein subfractions traditionally involved in cardiovascular risk, such as sdLDL, improved immediately after the residential program with values closest to those of healthy controls. CIMT improved throughout the lifestyle intervention. Using a generalized estimating equations model, none of the subfractions of lipoproteins nor apolipoproteins were linked to CIMT.ConclusionsLipoprotein subfractions traditionally involved in CVR, decreased after the 3-week residential program. During a 12 month follow-up, the time-related regains remained closer to the values of healthy controls than they were at baseline. CIMT improved throughout the lifestyle intervention. However, we failed to demonstrate a link between some lipoprotein subfractions and the atherogenicity directly measured from the wall thickness of arteries (CIMT). Further investigations are required to explore the atherogenicity of lipoprotein subfractions.Trial registrationNCT00917917

show abstract

Section: Discussioncontrasting

confidence: 71%

Atherogenic subfractions of lipoproteins in the treatment of metabolic syndrome by physical activity and diet – the RESOLVE trial

Dutheil

Walther²,

Chapier

et al. 2014

Lipids Health Dis

View full text Add to dashboard Cite

show abstract

“…However, recent studies have suggested that blood glucose variability is more deleterious than a constant high glucose as it accelerates diabetic macrovascular complications [17]. Xiao-min et al reported that parameters of glycemic variability calculated from CGM data, such as SD and MAGE, were increased as atherosclerosis progressed in patients with type 2 diabetes, and that increases in carotid intima-media thickness correlated significantly with MAGE [18]. Furthermore, accumulated data have indicated there is a significant relationship between glucose fluctuations and oxidative stress that may lead to the development of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Effect of repaglinide versus glimepiride on daily blood glucose variability and changes in blood inflammatory and oxidative stress markers

Yamazaki

Hasegawa

Majima

et al. 2014

Diabetol Metab Syndr

View full text Add to dashboard Cite

BackgroundHemoglobin A1c is the main treatment target for patients with type 2 diabetes. It has also been shown recently that postprandial glucose and daily glucose fluctuations affect the progression of diabetic complications and atherosclerotic damages.MethodsContinuous glucose monitoring was performed in patients with type 2 diabetes to evaluate the efficacy of repaglinide vs. glimepiride on postprandial glucose spikes and fluctuations. A total of 10 Japanese patients with type 2 diabetes treated with glimepiride monotherapy were enrolled. After observation period for 8 weeks, glimepiride was changed to repaglinide. Continuous glucose monitoring was performed whilst consuming calorie-restricted diets for two days at baseline and at the end of the 12-week trial. Blood and urine samples were collected for measurement of glucose control parameters and inflammatory and oxidative stress markers on the last day of taking either glimepiride or repaglinide.ResultsNine patients completed the trial. Although the glucose control parameters were not significantly different between glimepiride and repaglinide, the mean amplitude of glycemic excursions measured by continuous glucose monitoring was significantly reduced by changing treatment from glimepiride to repaglinide. The levels of plasminogen activator inhibitor-1, high sensitivity C-reactive protein, and urinary 8-hydoroxydeoxyguanosine were reduced significantly by repaglinide treatment.ConclusionThese results suggest that repaglinide may decrease the risk of cardiovascular disease in type 2 diabetes by minimizing glucose fluctuations thereby reducing inflammation and oxidative stress.

show abstract

“…Chen et al [22] studied 36 patients with type 2 diabetes and demonstrated that carotid IMT was correlated with MAGE. However, the authors used ultrasound to detect both preclinical atherosclerosis and the plaque formation.…”

Section: Discussionmentioning

confidence: 99%

Glycemic variability is associated with subclinical atherosclerosis in Chinese type 2 diabetic patients

Zhou

et al. 2013

Cardiovasc Diabetol

View full text Add to dashboard Cite

BackgroundThe contribution of glycemic variability to macrovascular complications remains unclear. We therefore investigated the association between glycemic variability and cervical and/or intracranial atherosclerosis in Chinese type 2 diabetic patients.MethodsWe conducted a cross-sectional study in 216 type 2 diabetic patients with a hemoglobin A1c of 8.3 ± 1.7% and a median diabetes duration of 9.0 years. The standard deviation of blood glucose values (SDBG) and the mean amplitude of glycemic excursion (MAGE) were calculated from continuous glucose monitoring system data for assessing glycemic variability while 24h mean blood glucose (MBG) was calculated for measuring overall blood glucose level. Magnetic resonance angiography (MRA) was used to detect cervical and/or intracranial plaque, and ultrasonography was used to quantify carotid intima-media thickness (IMT) as an index of subclinical atherosclerosis.ResultsOne hundred and fifty-three patients (70.8%) presented with cervical and/or intracranial lesions on MRA among 216 patients in the study. Elder age, increased systolic blood pressure, increased MBG and elevated low density lipoprotein cholesterol were independent contributors to plaque formation. In patients without stenosis (n = 63), SDBG (r = 0.412, P = 0.001) and MAGE (r = 0.365, P = 0.005) were both correlated with carotid IMT and these relationships remained significant in multiple linear regression analysis (multiple R2 = 0.314 for the model including SDBG and multiple R2 = 0.268 for the model including MAGE). However, SDBG and MAGE were not significantly different among patients with different stenosis degrees.ConclusionsGlycemic variability is associated with subclinical atherosclerosis in Chinese type 2 diabetic patients.

show abstract

Correlation between glucose fluctuations and carotid intima-media thickness in type 2 diabetes

Cited by 33 publications

References 19 publications

Atherogenic subfractions of lipoproteins in the treatment of metabolic syndrome by physical activity and diet – the RESOLVE trial

Atherogenic subfractions of lipoproteins in the treatment of metabolic syndrome by physical activity and diet – the RESOLVE trial

Effect of repaglinide versus glimepiride on daily blood glucose variability and changes in blood inflammatory and oxidative stress markers

Glycemic variability is associated with subclinical atherosclerosis in Chinese type 2 diabetic patients

Contact Info

Product

Resources

About