Correlation between hepatic human males absent on the first (hMOF) and viral persistence in chronic hepatitis B patients

Chen, Liwen; Zhu, Chengliang; Li, Fengdi; Wang, Yun; Bao, Rebecca; Xiang, Xiaogang; Yan, Lei; Lin, Lingnan; Zhao, Guijun; Xie, Qing; Bao, Shisan; Wang, Hui

doi:10.1186/s13578-018-0215-5

Cited by 4 publications

(2 citation statements)

References 32 publications

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“…The tissue array was generated following the methods as described ( 18 , 19 ). Subsequently, immunohistochemistry was conducted on sections obtained from these tissue arrays to assess the expression of IL-38, CD4, CD8, PD-1, CTLA-4, and FOXP3 on the draining lymph nodes containing metastatic CRC.…”

Section: Methodsmentioning

confidence: 99%

Exploring the clinical significance of IL-38 correlation with PD-1, CTLA-4, and FOXP3 in colorectal cancer draining lymph nodes

Yuan,

Tan,

Huang

et al. 2024

Front. Immunol.

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IntroductionColorectal cancer (CRC) presents a substantial challenge characterized by unacceptably high mortality and morbidity, primarily attributed to delayed diagnosis and reliance on palliative care. The immune response of the host plays a pivotal role in carcinogenesis, with IL-38 emerging as a potential protective factor in CRC. However, the precise involvement of IL-38 among various leucocytes, its interactions with PD-1/PD-L1, and its impact on metastasis require further elucidation.ResultsOur investigation revealed a significant correlation between IL-38 expression and metastasis, particularly concerning survival and interactions among diverse leucocytes within draining lymph nodes. In the mesentery lymph nodes, we observed an inverse correlation between IL-38 expression and stages of lymph node invasions (TNM), invasion depth, distance, and differentiation. This aligns with an overall survival advantage associated with higher IL-38 expression in CRC patients’ nodes compared to lower levels, as well as elevated IL-38 expression on CD4+ or CD8+ cells. Notably, a distinct subset of patients characterized by IL-38high/PD-1low expression exhibited superior survival outcomes compared to other combinations.DiscussionOur findings demonstrate that IL-38 expression in colorectal regional nodes from CRC patients is inversely correlated with PD-1/PD-L1 but positively correlated with infiltrating CD4+ or CD8+ lymphocytes. The combined assessment of IL-38 and PD-1 expression in colorectal regional nodes emerges as a promising biomarker for predicting the prognosis of CRC.

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Section: Methodsmentioning

confidence: 99%

Exploring the clinical significance of IL-38 correlation with PD-1, CTLA-4, and FOXP3 in colorectal cancer draining lymph nodes

Yuan,

Tan,

Huang

et al. 2024

Front. Immunol.

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“…chronically HIV-infected individuals' lymph nodes ( 20 ). Similarly, increases in percentages of circulating cells with a follicular regulatory phenotype are seen in individuals with untreated chronic hepatitis B infection ( 21 , 22 ). In an ex vivo HIV infection model, Tfr led to a decrease in Tfh ICOS expression and inhibited rates of Tfh proliferation ( 20 ).…”

Section: Tfr Regulation Of Tfhmentioning

confidence: 97%

Control of the Germinal Center by Follicular Regulatory T Cells During Infection

Brodie

Connick

2018

Front. Immunol.

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Follicular regulatory T cells (Tfr) are a unique subset of CD4 T cells that control and impact adaptive immune responses in the lymphoid follicles and germinal centers (GC). Since their relatively recent discovery, several studies have revealed that Tfr interact with other cells within this niche and shape ensuing responses. Recent advances defining the functional and developmental characteristics of Tfr have revealed key characteristics of Tfr differentiation, GC recruitment and retention, and regulatory properties. Further, Tfr shape the GC response and balance tolerance through interactions with Tfh, by modifying Tfh number, diversity and function, as well as with B cells. Mechanisms by which Tfr regulate the GC include cell-to-cell interactions with Tfh and B cells, as well as altering their environment through cytokine production and sequestration. Tfr have been shown to have a diverse T cell receptor (TCR) repertoire and can be specific for immunizing agents, demonstrating a potential role in vaccine development. Due to these important characteristics and functions, Tfr play a major role in immune tolerance, response to infection, and vaccine efficacy.

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Interleukin-38 in colorectal cancer: a potential role in precision medicine

Chen

Zhang

Tan

et al. 2019

Cancer Immunol Immunother

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Correlation between hepatic human males absent on the first (hMOF) and viral persistence in chronic hepatitis B patients

Cited by 4 publications

References 32 publications

Exploring the clinical significance of IL-38 correlation with PD-1, CTLA-4, and FOXP3 in colorectal cancer draining lymph nodes

Exploring the clinical significance of IL-38 correlation with PD-1, CTLA-4, and FOXP3 in colorectal cancer draining lymph nodes

Control of the Germinal Center by Follicular Regulatory T Cells During Infection

Interleukin-38 in colorectal cancer: a potential role in precision medicine

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