Correlation Between HLA-A, B and DRB1 Alleles and Severe Fever with Thrombocytopenia Syndrome

Ding, Shu Jun; Zhang, Yi; Zhang, Xiao Mei; Jiang, Xiao Lin; Pang, Bo; Song, Yong Hong; Wang, Jian Xing; Pei, Yao Wen; Zhu, Chuan Fu; Wang, Xian Jun; Yu, Xue Jie

doi:10.1371/journal.pntd.0005076

Cited by 5 publications

(5 citation statements)

References 25 publications

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“…In that study, serum IL-1β of non-fatal group was significantly lower than fatal group in the acute phase of SFTS, but dramatically elevated in 50–150 days after onset of illness, exhibiting late IL-1β response in the convalescent phase of SFTS. The differences could be due to the patient cohorts used in the studies 39 or the viruses that may have different pathogenic properties.…”

Section: Discussionmentioning

confidence: 99%

Downregulation of Interferon-β and Inhibition of TLR3 Expression are associated with Fatal Outcome of Severe Fever with Thrombocytopenia Syndrome

Song

Zheng

Zhang

et al. 2017

Sci Rep

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Severe Fever with Thrombocytopenia Syndrome (SFTS) is an emerging infectious disease with high mortality and increasing prevalence in the East Asia. Though the etiological agent has been identified as a novel Bunyavirus, cellular mechanisms of viral pathogenesis and host immune response to SFTS virus infection remain unknown. A comprehensive study was conducted on a cohort of 70 patients on clinical manifestations, viral loads, modulation of cytokines, serum interferon level, immune related gene expression in peripheral blood cells, and dynamic changes of circulating dendritic cells during the acute phase of SFTSV infection. We found that high level viremia, reduced platelets, coagulation dysfunction, multi-organ injuries, elevated IL-6 and TNF-α were closely associated with the aggravation of SFTS. In addition, we demonstrated strong correlations between disease severity and the decline of serum IFN-β and IL-1β level, reduction of myeloid dendritic cells (mDCs) and suppressed Toll like receptor 3 expression in monocytes and mDCs. In general, dysfunction of innate immune response and cytokine storm are both involved in the pathogenesis of SFTS. Reduction of myeloid DCs contributes to the fatal outcome of SFTS virus infection, and the regulation of TLR3 could probably be the mechanism.

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Section: Discussionmentioning

confidence: 99%

Downregulation of Interferon-β and Inhibition of TLR3 Expression are associated with Fatal Outcome of Severe Fever with Thrombocytopenia Syndrome

Song

Zheng

Zhang

et al. 2017

Sci Rep

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“…HLA alleles are highly variable in different individuals and are closely related to host immune response and the susceptibility to disease. The allele frequency distributions of HLA-A , HLA-B , and DRB1 between two cohorts (patients with SFTS: n = 84; healthy individuals: n = 501) from Shandong Province, China, were analyzed, and it was found that haplotype A*02-B*15-DRB1*04 was positively associated with SFTSV susceptibility, whereas HLA-A*30, HLA-B*13 and haplotype A*30-B*13 , A*30-B*13-DRB1*07 had negative correlation with SFTS susceptibility ( Ding et al., 2016 ).…”

Section: Host Genetic Factorsmentioning

confidence: 99%

The Endless Wars: Severe Fever With Thrombocytopenia Syndrome Virus, Host Immune and Genetic Factors

Wang

Tan

et al. 2022

Front. Cell. Infect. Microbiol.

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Severe fever with thrombocytopenia syndrome (SFTS) is an emerging arboviral infectious disease with a high rate of lethality in susceptible humans and caused by severe fever with thrombocytopenia syndrome bunyavirus (SFTSV). Currently, neither vaccine nor specific antiviral drugs are available. In recent years, given the fact that both the number of SFTS cases and epidemic regions are increasing year by year, SFTS has become a public health problem. SFTSV can be internalized into host cells through the interaction between SFTSV glycoproteins and cell receptors and can activate the host immune system to trigger antiviral immune response. However, SFTSV has evolved multiple strategies to manipulate host factors to create an optimal environment for itself. Not to be discounted, host genetic factors may be operative also in the never-ending winning or losing wars. Therefore, the identifications of SFTSV, host immune and genetic factors, and their interactions are critical for understanding the pathogenic mechanisms of SFTSV infection. This review summarizes the updated pathogenesis of SFTS with regard to virus, host immune response, and host genetic factors to provide some novel perspectives of the prevention, treatment, as well as drug and vaccine developments.

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“…Therefore, the alleles encoding the amino acid sequences in HLA directly affect the susceptibility to certain diseases, e.g., H1N1 influenza (HLA-A*11, DRB1*10, HLA-B*35) [ 10 ], dengue infection (HLA-B*51, HLA-B*52, HLA-B*46) [ 11 ], AIDS (HLA-B*52) [ 12 ], etc. [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…The loci A, B, C (class I) and loci DRB1, DQB1, and DPB1 (class II) of HLA genes are the most variable among all HLA genes, which determines their different affinity for the same antigen [ 15 ]. Furthermore, the linkage disequilibrium between alleles within a locus, as well as the haplotype frequencies within a population, may have a cumulative effect on antigen presentation [ 13 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

The Search of Association of HLA Class I and Class II Alleles with COVID-19 Mortality in the Russian Cohort

Cheranev

Bulusheva

Вечорко

et al. 2023

IJMS

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HLA genes play a pivotal role in the immune response via presenting the pathogen peptides on the cell surface in a host organism. Here, we studied the association of HLA allele variants of class I (loci A, B, C) and class II (loci DRB1, DQB1, DPB1) genes with the outcome of COVID-19 infection. We performed high-resolution sequencing of class HLA I and class II genes based on the sample population of 157 patients who died from COVID-19 and 76 patients who survived despite severe symptoms. The results were further compared with HLA genotype frequencies in the control population represented by 475 people from the Russian population. Although the obtained data revealed no significant differences between the samples at a locus level, they allowed one to uncover a set of notable alleles potentially contributing to the COVID-19 outcome. Our results did not only confirm the previously discovered fatal role of age or association of DRB1*01:01:01G and DRB1*01:02:01G alleles with severe symptoms and survival, but also allowed us to single out the DQB1*05:03:01G allele and B*14:02:01G~C*08:02:01G haplotype, which were associated with survival. Our findings showed that not only separate allele, but also their haplotype, could serve as potential markers of COVID-19 outcome and be used during triage for hospital admission.

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Correlation Between HLA-A, B and DRB1 Alleles and Severe Fever with Thrombocytopenia Syndrome

Cited by 5 publications

References 25 publications

Downregulation of Interferon-β and Inhibition of TLR3 Expression are associated with Fatal Outcome of Severe Fever with Thrombocytopenia Syndrome

Downregulation of Interferon-β and Inhibition of TLR3 Expression are associated with Fatal Outcome of Severe Fever with Thrombocytopenia Syndrome

The Endless Wars: Severe Fever With Thrombocytopenia Syndrome Virus, Host Immune and Genetic Factors

The Search of Association of HLA Class I and Class II Alleles with COVID-19 Mortality in the Russian Cohort

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