Correlation Between Hypothyroidism During Pregnancy and Glucose and Lipid Metabolism in Pregnant Women and Its Influence on Pregnancy Outcome and Fetal Growth and Development

Abstract

Purpose:To observe the correlation between hypothyroidism during pregnancy and glucose and lipid metabolism in pregnant women and its influence on a pregnancy outcome and fetal growth and development.MethodsAbout 152 patients with hypothyroidism during pregnancy in our hospital from June 2017 to June 2020 were selected as the observation group and divided into the overt hypothyroidism (OH) group, the subclinical hypothyroidism (SCH) group, and the low T4 group. Another 60 pregnant women with normal antenatal examination and normal thyroid function were selected as the normal group. The glucose and lipid metabolism indexes of each group were compared. The pregnant women in the OH group and the SCH group were given levothyroxine intervention, and the pregnancy outcome and infant development of the two groups were compared.ResultsThe fasting blood glucose and hemoglobin A1c, triglyceride and low-density lipoprotein of the OH group and the SCH group were higher than the low T4 group and the normal group, and the OH group was higher than the SCH group (p < 0.05). The incidence of premature delivery and premature rupture of membranes at term (PROM at term) in the hypothyroidism non-control group was higher than the hypothyroidism control group (p < 0.05). The mental development index and the psychomotor development index in the hypothyroidism non-control group were lower than the hypothyroidism control group (p < 0.05).ConclusionPregnant women with hypothyroidism during pregnancy are more prone to glucose and lipid metabolism disorder, which increases the risk of premature delivery and PROM at term, and has certain influence on the intellectual development and psychomotor development of infants.

Prevalence and Complications of Subclinical and Overt Hypothyroidism in Pregnancy at North Indian Tertiary Care Center

“…Similarly, positive correlation between maternal serum TSH and HbA1c has been also documented by other studies too. [ 26 , 27 ] Furthermore, systolic blood pressure was also significantly higher among hypothyroid mothers than among euthyroid mothers, which was one of the reasons behind the high incidence of preeclampsia among hypothyroid mothers. Study by Sardana D et al .…”

Correlation Study between Levels of Gastrin, Serum IGF-1, and GHBP and Growth and Development in Children with Short Stature Based on Big Data Analysis

“…In recent years, the real world study based on daily practice data in clinical care has been paid more and more attention, and big data application in medical field has been listed as the key development direction in China [ 23 , 24 ]. In this study, the laboratory tests were used to analyze the differences of growth and development indices, gastrin, serum IGF-1, and GHBP between children with SS and healthy children by big data, hoping to determine the correlation between the levels of gastrin, serum IGF-1, and GHBP and growth and development in children with SS by comparing the clinical data.…”

Iodine and Thyroid Maternal and Fetal Metabolism during Pregnancy

“…Indeed, maternal subclinical hypothyroidism during pregnancy is associated with a higher risk of low birth weight, and isolated hypothyroxinemia is associated with a higher risk of high birth weight [ 174 ]. The relationship between maternal TH serum concentration and birthweight could be mediated by triglycerides, as triglycerides are correlated with maternal fT4 and neonatal birthweight [ 175 , 176 ]. Maternal carnitine could also be involved in this process because its serum concentration during the second trimester–alongside fT4–has a negative influence on birthweight [ 177 ].…”