Correlation between IL-3 and IL-13 gene polymorphisms in Chinese patients and rheumatoid arthritis

Mj, Wang; Xd, Zhou; Zhang, H; Rp, Liu

doi:10.4238/gmr.15027966

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…One of the commonly examined versions of IL-13 is a single nucleotide polymorphism rs1800925 (-1055 C/T; promoter region). IL-13 rs1800925 has been studied in RA patients; however, no associations have been found between this genetic variant and a susceptibility to the disease in three different studies comprising Chinese and Caucasian populations [ 61 , 62 , 63 , 64 ]. Although stratification analyses in the study by Wang et al revealed that the C allele was associated with RA risk in Chinese patients with erythrocyte sedimentation rate (ESR) < 25.00 [ 64 ].…”

Section: Il-4 and Il-13 Polymorphism In Inflammatory Arthritismentioning

confidence: 99%

Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis

Iwaszko

Biały

Bogunia‐Kubik

2021

Cells

152

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Interleukin (IL)-4 and IL-13 belong to the T helper 2 (Th2) cytokine family, along with IL-3, IL-5, and IL-9. These cytokines are key mediators of allergic inflammation. They have important immunomodulatory activities and exert influence on a wide variety of immune cells, such as B cells, eosinophils, basophils, monocytes, fibroblasts, endothelial cells, airway epithelial cells, smooth muscle cells, and keratinocytes. Recent studies have implicated IL-4 and IL-13 in the development of various autoimmune diseases. Additionally, these cytokines have emerged as potential players in pathogenesis of inflammatory arthritis. Recent findings suggest that the IL-4 and IL-13 might play a significant role in the downregulation of inflammatory processes underlying RA pathology, and beneficially modulate the course of the disease. This review summarizes the biological features of the IL-4 and IL-13 and provides current knowledge regarding the role of these cytokines in inflammatory arthritis.

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Section: Il-4 and Il-13 Polymorphism In Inflammatory Arthritismentioning

confidence: 99%

Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis

Iwaszko

Biały

Bogunia‐Kubik

2021

Cells

152

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“…Single nucleotide polymorphisms (SNPs) are the most common genetic variations and if located in the coding regions of genes can result in loss, abrogation or altered function of the downstream protein by causing alterations in amino acid sequences and protein structure [ 28 , 29 ]. IL-13 gene is located on chromosome 5q23.31 and encodes IL-13 cytokine [ 30 ]. Single nucleotide polymorphisms substitution of the nucleotide cytosine (allele C) to thymine (allele T) at the IL-13 rs1800925 (also known as -1111C/T, -1055C/T and -1112C/T) site in the promoter region, results in the binding of nuclear proteins [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Interleukin-13 rs1800925/-1112C/T promoter single nucleotide polymorphism variant linked to anti-schistosomiasis in adult males in Murehwa District, Zimbabwe

2021

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Background Chronic schistosomiasis is predominantly induced through up-regulation of inflammatory cytokines such as interleukin (IL)-13. IL-13 may contribute to the disease outcomes by increasing eosinophil infiltration thereby promoting fibrosis. IL-13 may act as an immunosuppressive inflammatory cytokine that may promote carcinogenesis and also may offer protection against schistosomiasis thereby reducing risk of schistosome infections. Our study evaluated the frequency of the IL-13 rs1800925/-1112 C/ T promoter single nucleotide polymorphisms (SNPs) among schistosomiasis infected individuals and assessed the association of the variants on IL-13 cytokine levels. We also investigated IL-13 rs1800925 polymorphisms on prostate-specific antigen levels as an indicator for risk of prostate cancer development. Methodology The study was cross-sectional and included 50 schistosomiasis infected and 316 uninfected male participants residing in Murehwa District, Zimbabwe. IL-13 rs1800925 SNPs were genotyped by allele amplification refractory mutation system-polymerase chain reaction. Concentrations of serum prostate-specific antigens and plasma IL-13 were measured using enzyme-linked immunosorbent assay. Results Frequencies of the genotypes CC, CT and TT, were 20%, 58% and 22% in schistosomiasis infected, and 18.3%, 62.1% and 19.6% in uninfected participants with no statistical differences. There were significantly (p<0.05) higher IL-13 cytokine levels among both infected and uninfected participants with the genotypes CC and CT; median 92.25 pg/mL and 106.5 pg/mL, respectively, compared to TT variant individuals; 44.78 pg/mL. Within the schistosomiasis uninfected group, CC and CT variants had significantly (p<0.05) higher IL-13 levels; median 135.0 pg/mL and 113.6 pg/mL, respectively compared to TT variant individuals; 47.15 pg/mL. Within the schistosomiasis infected group, CC, CT and TT variant individuals had insignificant differences of IL-13 level. Using logistic regression, no association was observed between prostate-specific antigen levels, IL-13 cytokine levels and IL-13 rs1800925 variants (p>0.05). Conclusion IL-13 rs1800925 C variant individuals had the highest IL-13 cytokine levels among the schistosomiasis uninfected suggesting that they may be protective against Schistosoma infections. There was no association between IL-13 concentrations or IL-13 rs1800925 variants and risk of prostate cancer indicating that IL-13 levels and IL-13 rs10800925 may not be utilised as biomarker for risk of prostate cancer in schistosome infections.

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“…HLA loci account for ~50% of the genetic predisposition to RA . The polymorphisms and expression levels of several immune‐related genes, such as TCR‐CD3 ζ gene and IL‐13 gene, could affect the pathogenesis of RA. A few HLA alleles, such as HLA‐DRB1 , have also been proven as a risk for developing RA.…”

Section: Introductionmentioning

confidence: 99%

MICB002* and MICB014* protect against rheumatoid arthritis, whereas MICA009* and MICAA6* are associated with rheumatoid arthritis in a Hainan Han Chinese population

Wang

Chen

et al. 2018

Int J of Rheum Dis

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Correlation between IL-3 and IL-13 gene polymorphisms in Chinese patients and rheumatoid arthritis

Cited by 3 publications

References 27 publications

Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis

Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis

Interleukin-13 rs1800925/-1112C/T promoter single nucleotide polymorphism variant linked to anti-schistosomiasis in adult males in Murehwa District, Zimbabwe

MICB002* and MICB014* protect against rheumatoid arthritis, whereas MICA009* and MICAA6* are associated with rheumatoid arthritis in a Hainan Han Chinese population

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Correlation between IL-3 and IL-13 gene polymorphisms in Chinese patients and rheumatoid arthritis

Cited by 3 publications

References 27 publications

Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis

Significance of Interleukin (IL)-4 and IL-13 in Inflammatory Arthritis

Interleukin-13 rs1800925/-1112C/T promoter single nucleotide polymorphism variant linked to anti-schistosomiasis in adult males in Murehwa District, Zimbabwe

MICB*002 and MICB*014 protect against rheumatoid arthritis, whereas MICA*009 and MICA*A6 are associated with rheumatoid arthritis in a Hainan Han Chinese population

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MICB002* and MICB014* protect against rheumatoid arthritis, whereas MICA009* and MICAA6* are associated with rheumatoid arthritis in a Hainan Han Chinese population