Correlation between increased cortisol:DHEA ratio and malnutrition in HIV-positive men

Christeff, Névéna; Melchior, J.C.; Mammes, Olivier; Gherbi, Nora; Dalle, M; Nunez, Emmanuel A.

doi:10.1016/s0899-9007(99)00111-2

Cited by 31 publications

(13 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1A and B). An increased cortisol-to-DHEA ratio is observed in infectious diseases (19,29,30). Further analyses of the cortisol/DHEA ratio revealed that B. abortus-infected patients had a much higher ratio than healthy controls (Fig.…”

Section: Dhea and Cortisol In Brucellosis Patientsmentioning

confidence: 88%

“…The effects of DHEA are often opposed by the other important adrenal steroid, cortisol (18). The cortisol/DHEA ratio is abnormal under various pathological conditions such as AIDS, rheumatoid arthritis, and tuberculosis (18)(19)(20). In previous studies, significantly higher levels of cortisol in serum were reported in patients with acute brucellosis than in brucellosis patients at the end of antibiotic treatment or than in healthy subjects (21).…”

Section: Tion Most Of Them Secreted By Macrophages (Such As Interleumentioning

confidence: 98%

“…Cortisol and DHEA have opposite effects on immune responses (28), and they are imbalanced in certain infectious diseases and pathologies (19,29,30). Thus, we decided to investigate cortisol and DHEA levels in patients with acute brucellosis.…”

Section: Dhea and Cortisol In Brucellosis Patientsmentioning

confidence: 99%

“…Several cytokines that are produced during B. abortus infec- [18][19][20]. In previous studies, significantly higher levels of cortisol in serum were reported in patients with acute brucellosis than in brucellosis patients at the end of antibiotic treatment or than in healthy subjects (21).…”

mentioning

confidence: 97%

“…Macrophages/monocytes were recognized to play an important role in resistance to facultative intracellular bacteria such as Brucella, and activation of macrophages by specifically committed T lymphocytes formed the basis for cell-mediated immunity. However, B. abortus is endowed with a panoply of survival stratagems to evade immune responses and survive inside macrophages, creating a safe niche of replication inside the host (10-13).Several cytokines that are produced during B. abortus infec- [18][19][20]. In previous studies, significantly higher levels of cortisol in serum were reported in patients with acute brucellosis than in brucellosis patients at the end of antibiotic treatment or than in healthy subjects (21).…”

mentioning

confidence: 99%

See 4 more Smart Citations

Adrenal Steroids Modulate the Immune Response during Brucella abortus Infection by a Mechanism That Depends on the Regulation of Cytokine Production

et al. 2015

View full text Add to dashboard Cite

bHuman brucellosis is a protean disease with a diversity of clinical signs and symptoms resulting from infection with Brucella species. Recent reports suggest a cross-regulation between adrenal steroids (cortisol and dehydroepiandrosterone [DHEA]) and the immune system. Monocytes and macrophages are the main replication niche for Brucella. Therefore, we investigated the role of adrenal hormones on the modulation of the immune response mediated by macrophages in B. abortus infection. Cortisol treatment during B. abortus infection significantly inhibits cytokine, chemokine, and MMP-9 secretion. In contrast, DHEA treatment had no effect. However, DHEA treatment increases the expression of costimulatory molecules (CD40, CD86), the adhesion molecule CD54, and major histocompatibility complex class I (MHC- Human brucellosis is characterized by a great diversity of clinical manifestations resulting from infection with Brucella species (4). It is chiefly an inflammatory disease. Inflammation is present both in the acute and chronic phases of the disease and in practically all of the organs affected. Clinical signs of such inflammation are undulant fever, endocarditis, arthritis, osteomyelitis, meningitis, pleocytosis, cellular infiltration of the joints, orchitis, nephritis, hepatic granuloma, etc. (5).IBrucella abortus infection elicits a vigorous Th1 immune response, which also activates cytotoxic T lymphocytes (6-9). Despite the recognition that Th1 immunity is crucial for the control of Brucella infection, several aspects of the immune response, i.e., how the innate immune response shapes the adaptive Th1 immune response and why Th1 immunity is not sufficient to completely eradicate the infection, constitute a conundrum. Macrophages/monocytes were recognized to play an important role in resistance to facultative intracellular bacteria such as Brucella, and activation of macrophages by specifically committed T lymphocytes formed the basis for cell-mediated immunity. However, B. abortus is endowed with a panoply of survival stratagems to evade immune responses and survive inside macrophages, creating a safe niche of replication inside the host (10-13).Several cytokines that are produced during B. abortus infec- [18][19][20]. In previous studies, significantly higher levels of cortisol in serum were reported in patients with acute brucellosis than in brucellosis patients at the end of antibiotic treatment or than in healthy subjects (21). In addition, adrenal glands are enlarged in patients with acute brucellosis but return to normal size after therapy (21). Of note, Th1 Citation Gentilini MV, Velásquez LN, Barrionuevo P, Arriola Benitez PC, Giambartolomei GH, Delpino MV. 2015. Adrenal steroids modulate the immune response during Brucella abortus infection by a mechanism that depends on the regulation of cytokine production.

show abstract

Section: Dhea and Cortisol In Brucellosis Patientsmentioning

confidence: 88%

Section: Tion Most Of Them Secreted By Macrophages (Such As Interleumentioning

confidence: 98%

Section: Dhea and Cortisol In Brucellosis Patientsmentioning

confidence: 99%

mentioning

confidence: 97%

mentioning

confidence: 99%

See 3 more Smart Citations

Adrenal Steroids Modulate the Immune Response during Brucella abortus Infection by a Mechanism That Depends on the Regulation of Cytokine Production

et al. 2015

View full text Add to dashboard Cite

show abstract

A dual‐axis approach to understanding neuroendocrine development

Shirtcliff

Dismukes

Marceau

et al. 2015

Developmental Psychobiology

View full text Add to dashboard Cite

This paper on ‘a dual-axis approach to understanding neuroendocrine development’ sets out to introduce a series of paper about a novel perspective regarding stress and sex hormones, or what the authors within this special issue term ‘coupling’ of hypothalamic-pituitary-adrenal and –gonadal axes. This view postulates that these axes do not necessarily operate in opposition, but can operate together as evidenced empirically as a positive within-person association between stress hormones like cortisol or sex hormones like testosterone. A wealth of papers within the special issue demonstrate positive coupling across acute, diurnal, basal, and longitudinal timeframes and across several different types of contexts. Reviews were meant to challenge whether this was physiologically plausible. Consistently, sophisticated statistical models were utilized in order to show a template for how to model positive coupling and to ensure that coupling was a within-person phenomenon. We cautiously considered positive coupling until the consistency of observing positive coupling was robust enough for us to consider challenging the prevailing oppositional view of these axes. We do so to acknowledge that there are contexts, moments and stages in which the function of these axes should work together: for example when contexts are both stressful and challenging or at developmental stages (like adolescence) in which the youth must grow up despite the storm and stress of youth. We hope that by putting forward a functional dual-axis approach, the field will be able to consider when and how a dual-axis approach is useful.

show abstract

Role of dehydroepiandrosterone sulfate levels on body composition after laparoscopic adjustable gastric banding in pre-menopausal morbidly obese women

Savastano

Belfiore

Guida

et al. 2005

J Endocrinol Invest

View full text Add to dashboard Cite

LASGB associated with a well balanced low-calorie diet permits a satisfactory 2-yr weight loss, sparing FFM and without body fluid alterations. As the result of a stable weight reduction program weight loss is associated to decrease in cortisol, cortisol/DHEAS molar ratio, and insulin plasma levels with marked rise in DHEAS. Higher cortisol/DHEAS molar ratio values at baseline are also associated to lower weight loss after LASGB, with lower decrease in FM and higher reduction in FFM and body cell mass, in spite of no differences in dietary regimes. Cortisol/DHEAS molar ratio is likely to represent a reliable marker of favourable modifications in body composition.

show abstract

Correlation between increased cortisol:DHEA ratio and malnutrition in HIV-positive men

Cited by 31 publications

References 20 publications

Adrenal Steroids Modulate the Immune Response during Brucella abortus Infection by a Mechanism That Depends on the Regulation of Cytokine Production

Adrenal Steroids Modulate the Immune Response during Brucella abortus Infection by a Mechanism That Depends on the Regulation of Cytokine Production

A dual‐axis approach to understanding neuroendocrine development

Role of dehydroepiandrosterone sulfate levels on body composition after laparoscopic adjustable gastric banding in pre-menopausal morbidly obese women

Contact Info

Product

Resources

About