Correlation Between Intracellular Heat Shock Protein 70  Expression and Cervical Lymph Nodes Enlargement in Nasopharyngeal Carcinoma

Romdhoni, Achmad Chusnu; Herawati, Sri; Mustikaningtyas, Elida

doi:10.20473/fmi.v52i1.5205

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…Nasopharyngeal carcinoma (NPC) is a squamous cell carcinoma that appears in the nasopharynx (the area above the throat and behind the nose) .1 It is a malignant tumor that is easily infiltrate local tissues, metastasis and tumor growth is rapid (Romdhoni et al, 2016). The general prognosis of nasopharyngeal carcinoma (NPC) is currently based on the assessment of clinical stadium by assessing primary tumor (T), cervical metastatic nodule (N) and widespread metastasis (M) (Nugroho et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Predictive clinical factors for penetration-aspiration in patients with nasopharyngeal carcinoma after radiotherapy

Pratama

Romdhoni

Herawati

2022

ijhs

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Penetration-aspiration is the most serious complication in patients with nasopharyngeal carcinoma (NPC) after radiotherapy. Radiotherapy has been shown to increase the patient's survival rate and life expectancy but it showed serious side effects such as oropharyngeal dysphagia. It’s related morbidity and mortality such as penetration-aspiration could progress to aspiration pneumonia, sepsis, and death if not treated properly. Factors suspected to be the determinants of penetration-aspiration were the location of the pharyngeal residue, the stage of NPC, and the time after radiotherapy. This primary objective of this study was to determine the clinical factors of penetration-aspiration in patients with NPC after radiotherapy. In a cross sectional, observational analytic study, a total of 24 patients were obtained with consecutive sampling technique. Fiberoptic endoscopic evaluation of swallowing (FEES) examination was performed on patients with NPC after radiotherapy to assess pharyngeal residue and penetration-aspiration. The Yale Pharyngeal Residue Severity Rating Scale (YPR-SRS) and the Penetration-Aspiration Scale (PAS) was used to assess the presence of pharyngeal residue and penetration-aspiration, respectively. Statistical analysis used multiple logistic regression (p<0,05) and Wald statistics to find a stronger relationship between variables.

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Section: Discussionmentioning

confidence: 99%

Predictive clinical factors for penetration-aspiration in patients with nasopharyngeal carcinoma after radiotherapy

Pratama

Romdhoni

Herawati

2022

ijhs

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EBV-IgA antibody responses in endemic and nonendemic populations with nasopharyngeal carcinoma: tumour marker prognostication study and a cross-sectional study

Budiningsih,

Verkuijlen,

Dachlan

et al. 2023

Annals of Medicine &Amp; Surgery

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Nasopharyngeal carcinoma (NPC) is the most prevalent head and neck cancer in Indonesia, with 100% Epstein–Barr virus (EBV) infection in tumor cells. NPC is rare in the Netherlands. The involvement of EBV in NPC pathogenesis is reflected by early onset aberrant IgA antibody responses to various EBV proteins. Screening for elevated EBV-IgA levels is proposed for NPC risk assessment in endemic countries but is poorly studied in nonendemic regions. This study analyzed the overall diversity (immunoblot) as well as the prevalence and normalized levels of IgA responses to immunodominant peptide epitopes of EBV proteins VCA P18, EBNA 1, and Zebra (Zta) (N-terminus, P 125, P 130, full-length recombinant Zebra) in Indonesian (n=50) and Dutch (n=50) patients with NPC. The results confirmed that elevated levels of IgA-VCA P18 and IgA-EBNA 1 were found in both NPC populations, but that IgA-Zta was more variable. IgA-Zta responses were more pronounced in Indonesian NPC cases, reflecting more frequent EBV reactivation overall. IgA-VCA P18 and IgA-EBNA are independent tumor markers and are both necessary for NPC risk assessment. Overall, these results confirmed the diagnostic benefit of combined IgA-VCA P18/-EBNA 1 testing for NPC risk assessment in endemic and nonendemic populations.

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Correlation Between Intracellular Heat Shock Protein 70 Expression and Cervical Lymph Nodes Enlargement in Nasopharyngeal Carcinoma

Cited by 2 publications

References 32 publications

Predictive clinical factors for penetration-aspiration in patients with nasopharyngeal carcinoma after radiotherapy

Predictive clinical factors for penetration-aspiration in patients with nasopharyngeal carcinoma after radiotherapy

EBV-IgA antibody responses in endemic and nonendemic populations with nasopharyngeal carcinoma: tumour marker prognostication study and a cross-sectional study

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