Correlation between levels of LGR-5 (leucine rich repeat containing protein coupled receptor 5) with clinical aspects and colorectal carcinoma stage

Abstract

This study analyzes the colorectal cancer refers to gradually growing cancer that begins as tumor or tissue development in the internal layer of the rectum or stomach. CRC is resistant to chemotherapy and radiation and can cause collapse. This study is an analytical observational study using a cross-sectional study design with an evaluation stage of increasing LGR-5 levels on clinical aspects and stages of Colorectal Carcinoma patients in Makassar. Data collection was primary, where the data taken was demographic data and related to clinical aspects of the patient, namely, age, gender, cancer location, and cancer stage, lymph node participation, histopathological type when the patient came to treatment with diagnosis of colorectal cancer. The non-sanskari analysis was carried out on variables from the results of the study using contradiction analysis to determine the relationship between the increased level of LGR-5 and the stage of carcinogen ma patients based on AJCC. The analysis was carried out with the chi-square test. The value of significance is obtained when p <0.05.