Correlation between lipid peroxidation and non-enzymatic antioxidants in pregnancy induced hypertension

Abstract

The present study was designed to evaluate the lipid peroxidation and non-enzymatic antioxidants in pregnancyinduced hypertension (PIH) compared with healthy normal pregnant and non-pregnant as controls. 75 cases were studied of which 25 were normal healthy controls (Group A), 25 healthy pregnant women (Group B) of third trimester and 25 were PIH (Group C) of the same trimester. In PIH, malondialdehyde a lipid peroxidation product was significantly increased as compared to normal pregnant and non-pregnant controls. The nonenzymatic antioxidants like reduced glutathione, Vitamin-E, Vitamin-C and Vitamin-A were significantly decreased in normal pregnants as compared to controls. A further significant decrease was noticed in PIH compared to normal pregnants. A significant negative correlation was detected between lipid peroxidation and non-enzymatic antioxidant levels. Our study clearly indicates a relationship between elevated lipid peroxidation, decreased non-enzymatic antioxidant in PIH. The measurement of non-enzymatic antioxidants in plasma may be useful predictor of the likely development of PIH.

Evaluation of Oxidative Stress and Antioxidant Defence in Subjects of Preeclampsia

“…This result correlates well with numerous studies undertaken at many institutes. In India, studies conducted by Adiga, Patil et al [5] and Krishna Menon S [6] at different institutes showed significant elevations in the levels of malondialdehyde in preeclampsia compared to normal pregnancy and nonpregnant females. Outside India also, various studies like those by Elesa Llusla [7], Madazli R et al, and Chamy et al [8] have all found significantly increased MDA levels in preeclampsia as compared to normal pregnancy and also in pregnancy as such compared to non-pregnant females.…”

Cardiac troponins and oxidative stress markers in non-pregnant, pregnant and preeclampsia women

“…Results of the present study confirm increased oxidative stress during normal pregnancy and pregnancy-induced hypertension. Lipid peroxidetion may be an important factor in the pathogenesis of pregnancy-induced hypertension 26 .…”

Determination of glucose exchange rates and permeability of erythrocyte membrane in preeclampsia and subsequent oxidative stress-related protein damage using dynamic-19F-NMR

“…It has been suggested that polyunsaturated fatty acids are attacked by ROS and converted into lipid hydroperoxides as the initial factor leading to vascular endothelial dysfunction in PE (Howlander et al 2007; Kaur et al 2008; Hubel et al 1989; Davidge et al 1992; Mehendale et al 2008; Patil et al 2007). …”