Correlation Between Lipid Profile and Disease Severity in Psoriasis Patients of Dr. Sudirman Kebumen District Hospital Central Java Indonesia

Abstract

Psoriasis is a chronic inflammatory disease characterized by skin inflammation, epidermal hyperplasia, increased risk of arthritis, cardiovascular morbidity, and psychosocial challenges. Previous studies revealed the association of psoriasis with cardiometabolic diseases, in which dyslipidemia is a common feature. The objective of the study is to identify the correlation between lipid profile and disease severity in psoriasis patients. This study employed a cross-sectional design by using primary data from patients visiting the outpatient department of Dr Soedirman Kebumen District Hospital, Central Java. Disease severity was examined using Psoriasis Area and Severity Index (PASI) score. The levels of triglyceride, HDL-and LDL-cholesterol, and total cholesterol were measured from fasting blood plasma on the same day. Data were compared by utilizing one-way ANOVA or Kruskal-Wallis test as appropriate, and correlation between lipid levels and PASI score was analyzed by utilizing the Spearman correlation test. There were 33 psoriasis patients (20 male and 13 female) enrolled in this study; mean age was 43,6 ± 16,7 years old, and mean disease duration was 8,2 ± 9,5 years. Disease severity was mild in 19 (57,5%), moderate in 5 (15,2%), and severe in 9 (27,3%) patients, and mean PASI score was 12,8 ± 10,1. There were no significant differences of triglyceride levels (p = 0,700), HDL-cholesterol levels (p = 0,743), LDL-cholesterol levels (p = 0,840), and total cholesterol (p = 0,890) among groups of disease severity. There was no significant correlation between PASI score and triglyceride (r = 0,028; p = 0,879), HDL-cholesterol (r = −0,052; p = 0,775, LDL-cholesterol (r = −0,043; p = 0,812) and total cholesterol levels (r = −0,028; p = 0,875). However, there was a significant correlation between PASI score and disease duration (r = 0,423; p = 0,014). Meanwhile, there was no significant correlation between disease severity and lipid profile in psoriasis patients.