Correlation Between Localized Choriocapillaris Perfusion and Macular Function in Eyes with Geographic Atrophy

Rinella, Nicholas; Zhou, Hao; Wong, Jessica J.; Zhang, Qinqin; Nattagh, Khashayar; Porco, Travis C.; Wang, Ke; Schwartz, Daniel M.; Duncan, Jacque L.

doi:10.1016/j.ajo.2021.08.007

Cited by 7 publications

(5 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is good evidence that microvascular changes affecting the choriocapillaris occur in aging and are exacerbated in eyes with NN-AMD, suggesting that relative ischemia to the macula plays a role. 44 There is supporting evidence that the greatest VEGF levels occur during the intermediate stage of NN-AMD (compared with early NN-AMD or during active CNV). 45 Hypoxic regions of retina show low rates of apoptosis owing to widespread senescent cells, 37 which secrete high levels of VEGF and simultaneously downregulate complement factor H expression.…”

Section: Discussionmentioning

confidence: 92%

Aqueous Fluid Transcriptome Profiling Differentiates Between Non-Neovascular and Neovascular AMD

Kaidonis

Lamy

et al. 2023

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Purpose Early and intermediate non-neovascular AMD (NN-AMD) has the potential to progress to either advanced NN-AMD with geographic atrophy, or to neovascular AMD (N-AMD) with CNV. This exploratory study performed an unbiased analysis of aqueous humor transcriptome in patients with early or intermediate NN-AMD vs. treatment-naïve N-AMD to determine the feasibility of using this method in future studies investigating pathways and triggers for conversion from one form to another. Methods Aqueous humor samples were obtained from 20 patients with early or intermediate NN-AMD and 20 patients with untreated N-AMD, graded on clinical examination and optical coherence tomography. Transcriptome profiles were generated using next-generation sequencing methods optimized for ocular samples. Top-ranked transcripts were compared between groups, and pathway enrichment analysis was performed. Results Seventy-eight differentially expressed transcripts were identified. Unsupervised clustering of differentially expressed transcripts was able to successfully differentiate between the two groups based on aqueous transcriptome alone. Pathway analysis highlighted changes in expression of genes associated with mitochondrial respiration, oxidative stress, ubiquitination, and neurogenesis between the two groups. Conclusions This pilot study compared the aqueous fluid transcriptome of patients with early or intermediate NN-AMD and untreated N-AMD. Differences in transcripts and transcriptome pathways identified in the aqueous of patients with early or intermediate NN-AMD compared with patients with N-AMD are consistent with those previously implicated in the pathogenesis of these distinct AMD subtypes. The findings from this exploratory study warrant further investigation using a larger, prospective study design, with the inclusion of a control group of eyes without AMD.

show abstract

Section: Discussionmentioning

confidence: 92%

Aqueous Fluid Transcriptome Profiling Differentiates Between Non-Neovascular and Neovascular AMD

Kaidonis

Lamy

et al. 2023

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…The magnitude of the choriocapillaris flow void was further translated to the macular function in the same region; This corresponded with a recent observation showing a significant invert correlation between choriocapillaris flow deficits and retinal sensitivity measured by microperimetry at each localized area. Expectedly, choriocapillaris flow and retinal sensitivity improved with distance from the GA border ( 44 , 45 ).…”

Section: Discussionmentioning

confidence: 97%

The role of dual antiplatelets in geographic atrophy secondary to non-neovascular aged-related macular degeneration

Chantarasorn

Smitthimathin²,

Vorasayan³

2022

Front. Ophthalmol.

View full text Add to dashboard Cite

BackgroundTo evaluate the effects of dual antiplatelets on progression of geographic atrophy (GA) secondary to age-related macular degeneration (AMD), and to determine additional factors predicting rapid GA growth.Material and MethodsIn this retrospective cohort study, patients with unifocal GA were consecutively enrolled (one eye per patient) from 2018 to 2021. The patients were categorized as 1. those receiving dual antiplatelet therapy containing a daily dose of 75 mg clopidogrel plus 81 mg aspirin (DAPT group), and 2. those not receiving DAPT (control group). Areas of GA, based on red-filtered fundus autofluorescence, were measured at baseline, and at 3, 6, and 12 months. The primary outcome was absolute 12-month changes in the square root (SQRT) area.ResultsOne eye in each group developed neovascular AMD and was excluded from the analysis. The DAPT (24 eyes) and control (22 eyes) groups had comparable age and baseline SQRT area (1.2 ± 0.27 and 1.8 ± 0.41 mm, respectively; p adjusted for age = 0.23). At 12 months, after controlling for age and the presence of soft drusen or reticular pseudodrusen, patients receiving DAPT had fewer changes in the SQRT area than that of the control group (0.097 vs. 0.17 mm; p = 0.02). The presence of drusen significantly predicted increased GA growth and choroidal thickness reduction.ConclusionsRoutine uses of dual antiplatelets were associated with decelerating GA growth. Drusen-associated GA may represent a generalized form of choroidal vascular alterations.

show abstract

“…A study by Pfau et al 31 instead reported that visual sensitivity was significantly reduced for test locations between approximately 125 to 250 µm outside the GA margin, when compared with those further away, between approximately 375 and 875 µm. Finally, a study by Rinella et al 32 reported that visual sensitivity showed a strong correlation with the distance from the GA margin (Pearson's r = 0.79), with progressive decreases reported for locations between 0 to >5 mm outside the GA margin in 1-mm bins, although statistical testing for the difference between each bin was not performed. Our finding that the probability of missing stimuli on defect-mapping microperimetry testing was significantly higher for locations in the outer junctional zone (0–500 µm outside of the GA margin) compared with those in the outer nonlesional zone (>1000 µm away) falls generally within the range of the observations reported in the aforementioned studies.…”

Section: Discussionmentioning

confidence: 99%

“…Our finding that the probability of missing stimuli on defect-mapping microperimetry testing was significantly higher for locations in the outer junctional zone (0–500 µm outside of the GA margin) compared with those in the outer nonlesional zone (>1000 µm away) falls generally within the range of the observations reported in the aforementioned studies. 30 – 32 …”

Section: Discussionmentioning

confidence: 99%

Visual Sensitivity Loss in Geographic Atrophy: Structure–Function Evaluation Using Defect-Mapping Microperimetry

Wu,

Hadoux,

Jannaud

et al. 2024

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Purpose To examine the structure–function relationship in eyes with geographic atrophy (GA) using defect-mapping microperimetry, a testing strategy optimized to quantify the spatial extent of deep visual sensitivity losses. Methods Fifty participants with GA underwent defect-mapping microperimetry testing of the central 8°-radius region (208 locations tested once with a 10-decibel stimuli) and fundus autofluorescence imaging in one eye. The GA extent in the corresponding central 8°-radius was derived by manual annotations and image co-registration to examine the global structure–function relationship. The distance of each test location from the GA margin was also derived, and regions defined, to examine the local structure–function relationship. Results GA extent in the central 8° explained a substantial proportion of variance in the percentage of locations missed (nonresponse) on microperimetry at the global level ( R 2 = 0.90). At a local level, the probability of missing stimuli at the outer junctional zone (0–500 µm outside the GA margin) and GA margin (probability = 7% and 34%, respectively) was higher than at the outer nonlesional zone (>500 µm outside the GA margin; probability = 2%; P < 0.001 for both). The probability of missing stimuli at the inner junctional zone (0–250 µm inside the GA margin) was also lower than at the inner lesional zone (>250 µm inside the GA margin; probability = 64% and 88%; P < 0.001). Conclusions This study confirms the expected functional relevance of the region with GA on fundus autofluorescence imaging and underscores the potential effectiveness of defect-mapping microperimetry testing for capturing visual function changes when evaluating new GA treatments.

show abstract

Correlation Between Localized Choriocapillaris Perfusion and Macular Function in Eyes with Geographic Atrophy

Cited by 7 publications

References 39 publications

Aqueous Fluid Transcriptome Profiling Differentiates Between Non-Neovascular and Neovascular AMD

Aqueous Fluid Transcriptome Profiling Differentiates Between Non-Neovascular and Neovascular AMD

The role of dual antiplatelets in geographic atrophy secondary to non-neovascular aged-related macular degeneration

Visual Sensitivity Loss in Geographic Atrophy: Structure–Function Evaluation Using Defect-Mapping Microperimetry

Contact Info

Product

Resources

About