Correlation between malondialdehyde (MDA) and uric acid levels in preeclampsia

Abstract

INTRODUCTIONHypertensive disorders during pregnancy complicate 7-10% of total pregnancies , out of which 70% are preeclamptic. It increases perinatal mortality by five fold and kills 50,000 women worldwide.1 Preeclampsia is a multisystem disorder characterised by hypertension to the extent of 140/90 mm of Hg or more, proteinuria (≥ 300 mg /day) and oedema induced by pregnancy after 20 th week. Without intervention, preeclampsia progresses to eclampsia.Despite considerable research, the pathophysiology of preeclampsia remains unclear. However, oxidative stress has been attributed to be the causative factor of preeclampsia. 3 Lipid peroxidation is event of oxidative stress . Low density lipoproteins are more susceptible for free radical oxidation leading to generation of Malondialdehyde (MDA). This can be the major factor that induces endothelial dysfunction . 4 Slemons and Begort first observed an association between serum uric acid and the presence of pregnancy induced hypertension (PIH). Stander and Cadden were first to demonstrate a high correlation between the ABSTRACT Background: Hypertensive disorders of human pregnancy, such as preeclampsia, complicates a sizeable percentage of all pregnancies, need its early indication and warning. The aim of present study was to determine the association between lipid peroxidation product, serum malondialdehyde (MDA) and serum uric acid levels in preeclampsia and find out any association between these two parameters in preeclampsia. Methods: Thirty preeclampsia and thirty gestational age matched normotensive pregnant women attending Narayana General Hospital, Nellore were included in the study. Serum MDA levels were measured by Thiobarbituric acid reactive substances(TBARS) method and serum uric acid levels were estimated by automated chemistry analyser using commercial kits. Results: Serum MDA (Mean±SEM 24.4±2.38 vs 7.9± 0.28 nmol/ml, p value < 0.000) and serum uric acid levels (7.2 ± 0.25 vs 3.9 ± 0.14 mg/dl, p value <0.000) were significantly elevated in preeclampsia cases when compared with that of normotensive pregnant women. A weak positive correlation between serum uric acid and serum MDA (r value 0.065, p value 0.734) was noticed in preeclampsia. Conclusion: Serum MDA and uric acid may be included as additional markers for screening and progression of preeclampsia, thereby helpful in effectively treating the condition at an early stage.

Suppression of Adenosine Deaminase and Xanthine Oxidase Activities by Mineralocorticoid and Glucocorticoid Receptor Blockades Restores Renal Antioxidative Barrier in Oral Contraceptive-Treated Dam

“…Elevated XO activity and its resulting increased uric acid level have been implicated in the pathogenesis and progression of ROS-induced renal diseases [ 26 ]. Malondialdehyde (MDA), a frequently used indicator of oxidative damage to tissues, is linked to uric acid production in preeclamptic women [ 59 ]. Also, overproduction of MDA resulting from increased FFA has been observed in condition of renal injury [ 60 ].…”

Uric acid as a predictor of endothelial dysfunction in patients with metabolic syndrome

“…Krishna and cols. found higher serum uric acid and MDA levels in patients with pre-eclampsia, but uric acid and MDA levels had a weak correlation between themselves ( 19 ). This suggests that uric acid may be one of many factors causing increased oxidative stress seen in individuals with metabolic syndrome, though not corroborated by our findings.…”