Correlation between mild hypoxaemia and limb skeletal muscle function in chronic obstructive pulmonary disease – Pilot study

Rodrigues, Sérgio Leite; Silva, César Augusto Melo e; Amorim, César Ferreira; Lima, Terezinha; Ribeiro, Fernanda; Viegas, Carlos Alberto de Assis; Amado, Verônica Moreira

doi:10.1016/s2173-5115(08)70307-5

Cited by 1 publication

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Exercise performance depends on aerobic metabolism and oxidative capacity. Hypoxemia has been linked to a more glycolytic muscle profile and ultimately with the decline in 6MWT 12. Our hypoxemic patients also experienced more severe oxygen desaturation during the 6MWT.…”

Section: Discussionmentioning

confidence: 59%

See 1 more Smart Citation

Functional capacity, physical activity, and quality of life in hypoxemic patients with chronic obstructive pulmonary disease

Sağlam

Vardar-Yağlı

Savcı

et al. 2015

COPD

View full text Add to dashboard Cite

BackgroundThe risk of hypoxemia increases with the progression of chronic obstructive pulmonary disease (COPD) and the deterioration of pulmonary function. The aim of this study was to compare functional capacity, physical activity, and quality of life in hypoxemic and non-hypoxemic patients with COPD.MethodsThirty-nine COPD patients (mean age: 62.0±7.03 years) were included in this study. Arterial blood gas tensions were measured, and patients were divided into two groups according to oxygen partial pressure (PaO2), the hypoxemic COPD (PaO2 <60 mmHg) (n=18), and the control (PaO2 ≥60 mmHg) (n=21) groups. Functional exercise capacity was evaluated using the 6-minute walk test (6MWT). Oxygen saturation, dyspnea, and fatigue perception were measured before and after the 6MWT. Physical activity was assessed using the International Physical Activity Questionnaire (IPAQ) and an accelerometer. Quality of life was assessed using the St George’s Respiratory Questionnaire (SGRQ).ResultsThe number of emergency visits and hospitalizations were higher in hypoxemic patients (P<0.05). Lung function parameters, 6MWT distance, exercise oxygen saturation, IPAQ total score, and energy expenditure during daily life were significantly lower, but percentage of maximum heart rate reached during the 6MWT was significantly higher, in hypoxemic COPD patients than in controls (P<0.05).ConclusionHypoxemia has a profound effect on functional capacity and physical activity in patients with COPD.

show abstract

Section: Discussionmentioning

confidence: 59%

“…Few studies have examined hypoxemia and related factors including exercise capacity, muscle function, and quality of life 6,12,13. To our knowledge, no published study has examined whether quality of life, functional capacity, and physical activity change between hypoxemic and non-hypoxemic COPD patients.…”

Section: Introductionmentioning

confidence: 99%