Correlation Between Neutrophil-Lymphocyte Ratio, Platelets-Lymphocyte Ratio, and High-Resolution CT in Patients with COVID-19

Hussini, Manal S.H. El; Hussieny, Mohamed S. El; Heiba, Ahmed; Elsayed, Enass Sayed M.; Hassan, Nayera E.; El-Masry, Sahar A.

doi:10.33590/emjradiol/10085604

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…Due to its unique proposal for grading the severity of tonsillitis and its precise evaluation of neutrophil count, this study became an appealing model for indirectly assessing the severity of NF through consecutive neutrophil counts. [13][14][15][16][17][18] Extensive research has been published on the subject of NF. Research has demonstrated a paradoxical relationship between the way a disease presents clinically and how it progresses.…”

Section: Introductionmentioning

confidence: 99%

Serial neutrophils count as a stratifying tool for early follicular tonsilitis remission

Hayfa Suleiman Mefleh Obeidat,

Wajdi Nidal Jeries Smirat,

Mousa Mohammad Ali Almashagbah

et al. 2024

World J. Bio. Pharm. Health Sci.

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Background/Aim: This study examines the correlation between sequential serum neutrophil levels and the overall improvement status or reduction rate of intravenous antibiotic administration. This study seeks to identify a cost-effective and easily accessible biomarker that can accurately predict the need for hospitalisation in patients with acute tonsillitis who are receiving intravenous broad-spectrum antibiotics. The goal is to determine the patients' suitability for early discontinuation of intravenous antibiotics and discharge. Methods: This study was conducted at the King Hussein Medical Centre in Jordan, focusing on patients with severe acute tonsillitis who did not respond to oral antibiotics. Data was collected from the electronic medical record system (Hakeem) from January 2018 to May 2021. The study classified serial serum neutrophil measurements during the first week of hospital admission into four categories. The levels were compared between the non-penicillin Cohort (Group I) and penicillin Cohort (Group II) using an Independent-T Test. The outcomes of interest included a drop in neutrophil counts exceeding 50%, a decrease in the use of intravenous antibiotics in favor of oral antibiotics, and early eligibility for discharge. The study also examined serial neutrophil counts over the tested days and compared to the outcomes of positive and negative states using receiver operating curve analyses. The optimal cutoff operating point for each ROC curve was determined by selecting the highest Youden's index of each prognosticator day level. The analysis of all results was conducted using SPSS version 20 with a significance level set at p-value <0.05. Results: This study analyzed 1638 adult and elderly patients admitted to KHMC, RMS, Amman, Jordan between January 2018 and May 2021. The average age was 51.88±16.22 years, with patients dependent on intravenous penicillin being slightly older. The distribution of males and females was significant, with males making up 2.55 times the number of females. The odds ratio for positive outcomes was 4.12, with a high rate of poor outcomes in 1318 out of all eligible patients. A total of 994 (60.7%) medical patients were treated with intravenous administration, while 644 (39.3%) surgical patients were scheduled for a tonsillectomy procedure. The risk estimate for patients admitted from medical wards compared to surgical wards was an odds ratio of 0.562. The study also provided sensitivity analysis for the four tested serial neutrophil prognosticators at different day levels. Conclusion: The study supports the use of Somatic Nucleated Cell (SNC) as a reliable measure for evaluating EFR in cases of catarrhal acute tonsillitis. The maximum SNC count in Group one was 11,269 cells per cubic millimeter. Acute streptococcal infection often exhibits an ESR higher than 40, but this may be concealed by other complications. The SNC test has advantages like simplicity, quickness, and cost-effectiveness, but lacks specificity. Monitoring SNC and EFR fluctuations can initiate treatment cessation, preventing relapse and severe complications during recovery.

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Section: Introductionmentioning

confidence: 99%

Serial neutrophils count as a stratifying tool for early follicular tonsilitis remission

Hayfa Suleiman Mefleh Obeidat,

Wajdi Nidal Jeries Smirat,

Mousa Mohammad Ali Almashagbah

et al. 2024

World J. Bio. Pharm. Health Sci.

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“…PLR was also described as an easily obtained inflammatory marker. Its role in COVID-19 patients is more ambiguous [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Do Neutrophil–Lymphocyte Ratio and Platelet–Lymphocyte Ratio Need to Be Stratified for Age and Comorbidities in COVID-19 Disease? A Subgroup Analysis of Two Distinct Cohorts over Disease Course

Kagansky,

Levy,

Awar

et al. 2024

JCM

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Several studies described neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR) as markers of COVID-19 severity. In a recently published study, age and frailty affected NLR and PLR more than disease severity. The study compared two distinct cohorts. The first comprised older frailer patients positive for SARS-CoV-2, with mild or asymptomatic disease, admitted to designated COVID-19 departments in a large geriatric medical center (GMC). The second cohort comprised COVID-19 patients admitted to a large general hospital (GH) for symptomatic disease. This was a follow-up study comparing a subgroup of patients who had NLR and PLR values measured a week after admission. Only 100 of 177 patients in the original GMC cohort had a second NLR test compared to almost all (287 of 289) patients in the general hospital (GH) cohort. The subgroup baseline characteristics did not change significantly from that of the original cohort. Disease symptoms were more prevalent in the GH cohort. In the GMC group, the median second NLR rose from 3.9 to 4.6, while in the GH cohort, the NLR value dropped from 3.5 to 2.8, enhancing the NLR differences between the groups. Smaller changes were observed in the second PLR. These results strengthen the prior results that age and frailty seem to have a stronger impact on NLR and PLR than disease severity.

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Correlation Between Neutrophil-Lymphocyte Ratio, Platelets-Lymphocyte Ratio, and High-Resolution CT in Patients with COVID-19

Cited by 2 publications

References 18 publications

Serial neutrophils count as a stratifying tool for early follicular tonsilitis remission

Serial neutrophils count as a stratifying tool for early follicular tonsilitis remission

Do Neutrophil–Lymphocyte Ratio and Platelet–Lymphocyte Ratio Need to Be Stratified for Age and Comorbidities in COVID-19 Disease? A Subgroup Analysis of Two Distinct Cohorts over Disease Course

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