Correlation Between Neutrophil to Lymphocyte Ratio Baseline with Spirometry Test in Severe Coronavirus Disease 2019 (COVID-19)

Abstract

Background/aim: The sequelae of the post-COVID-19 syndrome can affect lung function. The neutrophil-lymphocyte ratio is one of the markers of increased inflammation in SARS-CoV-2 virus infection. Based on this, the researchers wanted to assess the relationship between baseline NLR levels and spirometry tests in severe COVID-19 survivors. Methods: This research is an observational analytic study with a cross-sectional design conducted at Prof. Dr. IGNG Ngoerah Hospital Denpasar from January 2022 to July 2022. Univariate analysis displays the mean, standard deviation, and relative frequency for categorical data. Bivariate analysis was performed by chi-squared test. The multivariate analysis used was multiple logistic regression to assess the relationship between baseline NLR levels and covariates with the spirometry test. Results: Subjects who participated in the study were 80. As many as 58 subjects (72.5%), the baseline NLR value was 3.58%, and the median NLR was 5.41% (1.19-514%). On spirometry examination, there were restrictions on 41 subjects (51.2%), mild Restriction in 38 subjects (47.5%), Obstruction in 8 subjects (10%), benign Obstruction in 5 subjects (6.3%). The multivariate correlation between baseline NLR and spirometry results (FVC, FEV1, FEV1/FVC, and FEF 25-75%) showed no relationship Conclusion: There is no relationship between high baseline NLR and FVC, FEV1, FEV1/FVC, and FEF25-75% values. Keywords: COVID-19, CRP, Lymphocyte, FVC, FEV1/FVC, FEF 25-75