Correlation between Oral Hygiene and IL-6 in Children

Giudice, Roberto Lo; Militi, Angela; Nicita, Fabiana; Bruno, Giordano; Tamà, Cristina; Giudice, Fabrizio Lo; Puleio, Francesco; Calapai, Fabrizio; Mannucci, Carmen

doi:10.3390/dj8030091

Cited by 14 publications

(13 citation statements)

References 29 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients with myofascial pain syndrome report symptoms such as frustration, anxiety, depression and maladaptive behaviors such as pain, inadequate sleep and incorrect eating habits. A burning sensation in the oral cavity is a condition found in patients with psychological, behavioral or sleep disorders [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical and Pathological Manifestation of the Oral Mucosa in Institutionalized Children from Romania

Stoica

Kovacs-Ivacson²,

Stoica³

et al. 2022

IJERPH

View full text Add to dashboard Cite

Institutionalized children, regardless of their age, are prone to psychiatric disorders, compared to those who live in two-parent families, due to the unfavorable physical and psychological conditions in which they develop. Unpropitious psychological conditions affect the child’s general health and induce local manifestations that can be found in the oral cavity, affecting both soft tissues and teeth. Therefore, the purpose of our study was to assess and diagnose a series of pathological manifestations of the oral mucosa associated with poor living conditions or closely related to psychological stress. The clinical examination was performed by 4 specialist dentists, who consulted 150 children representing the study group and 52 children representing the control group, all having ages between 14 and 18 years old and meeting the same inclusion criteria. From the control group, 62.5% presented plaque-induced gingivitis (26.6% girls, 35.8% boys), 26.6% presented mucosal lesions produced by lip and cheek biting (23.3% girls, 35.8% boys), and 11.7% presented geographic tongue (6.6% girls, 5% boys), herpes simplex eruptions (3.3% girls, 4.2% boys) and oral ulcerations (12.5% girls, 10.8% boys). Morsicatio buccarul is a chronic, self-mutilating habit, currently becoming one of the most common tics encountered among institutionalized children. Furthermore, these children do not benefit from constant support and guidance to perform their dental hygiene, so the incidence of gingivitis induced by bacterial plaque and calculus is very high.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical and Pathological Manifestation of the Oral Mucosa in Institutionalized Children from Romania

Stoica

Kovacs-Ivacson²,

Stoica³

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…One of the mechanisms of mucosal immunity is an increased secretion level of IgA in saliva [ 11 ]. Not only IgA was noticed to increase in these circumstances, as recently IL-6 was reported to increase, specially in children with poor oral hygiene performance indices, gingival inflammation and the presence of plaque [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Physiological and Immunological Changes Associated with Oral Microbiota When Using a Thermoplastic Retainer

Al-Lehaibi

Al-Makhzomi²,

Mohammed

et al. 2021

Molecules

View full text Add to dashboard Cite

Background: The study examined the oral microbiota, physiological and immunological changes in patients using thermoplastic retainers during three months of use. Methods: The study included several steps. Firstly, 10 swabs were collected from the buccal and palatal surfaces of the teeth of the patients, approximately 2 mL of saliva was collected from the same patients and 2 mL of saliva was collected from 10 healthy people to measure the pH and secretory IgA level. This was followed by the isolation and identfication of the bacterial isolates in the patient samples. Then, isolate susceptibility toward chlorhexidine (CHX) and their adhesion ability to thermoplastic retainer surfaces was measured. In addition to that the study estimated the numbers of Lactobacillus and Streptooccus mutans colonies during three months and finally, a comparsion of pH acidity and IgA level between the patients and healthy people was performed. The results showed the predominant bacteria during the three months were Lactobacillus spp and Streptococcus spp followed by different rates of other bacteria. Raoultella ornithinolytica showed more resistance to CHX while Lactobacillus spp. showed more sensitivity. Streptococcus mutans colony levels were higher than Lactobacillus spp colonies during the three months, also S. mutans had the highest value in adherence to retainer thermoplastic. Finally, pH acidity showed a highly significant difference (p ≤ 0.05) in the third month, like IgA levels (p ≤ 0.05). Conclusions: According to the results obtained from the current study, the researchers noted that the thermoplastic retainers helped change the oral cavity environment.

show abstract

“…Giudice et al [49] in a clinical study observed high levels of salivary IL-6 in children with active caries in comparison to the caries-free group. In another study conducted by the same research group [62] the authors suggested that low-quality plaque control, plaque accumulation and gingival inflammation can induce an increase of IL-6 levels in gingival crevicular fluid in children.…”

Section: Insights On the Role Of Cytokines In Carious Lesionsmentioning

confidence: 99%

“…The human interleukin 6 is a helical-shaped protein composed of 212 amino acids, is a pleiotropic cytokine produced by a variety of nonimmune and immune cells which is responsible to regulate many aspects of the local immune response, such as T-cells and macrophage cells. IL-6 have pro-and anti-inflammatory effects, involved in inflammation response, tissue injury and regenerative processes [12,62]. This cytokine is strongly upregulated in bacteria-challenged inflamed pulps in vivo and in odontoblasts in vitro upon TLR2 engagement [63,64].…”

Section: Interleukin-6mentioning

confidence: 99%

See 1 more Smart Citation

Insights on the role of cytokines in carious lesions

Gonçalves¹,

Kim

Bortolatto

et al. 2023

Braz. Dent. Sci.

View full text Add to dashboard Cite

Objectives:The dentin-pulp immune response to caries pathogenesis is still poorly understood due to the complex interplay of the involving processes. The aim of this review was to explore the role of cytokines and its relevance in the pathogenesis of dental caries. Results: Dental caries can result in a host inflammatory response in the dental pulp, characterized by the accumulation of inflammatory cells leading to the release of inflammatory cytokines such as Interleukin-4 (IL-4), Interleukin (IL-6), Interleukin-8 (IL-8) and Tumor necrosis factor-α (TNF-α). IL-4 seems to be correlated to the depth of carious lesions; IL-6 is strongly correlated to caries disease and is considered a potent biomarker; IL-8 can be a potent biomarker for both caries and other changes present in the pulp and, its release is correlated to TNF-α and IL-6; TNF-α plays an important role not only in caries progression, but also in other pathological processes. Conclusion: Specific mediators have a great potential to serve as biomarkers alluding to the presence and progress of caries disease, urging further investigations in the field.

show abstract

Correlation between Oral Hygiene and IL-6 in Children

Cited by 14 publications

References 29 publications

Clinical and Pathological Manifestation of the Oral Mucosa in Institutionalized Children from Romania

Clinical and Pathological Manifestation of the Oral Mucosa in Institutionalized Children from Romania

Physiological and Immunological Changes Associated with Oral Microbiota When Using a Thermoplastic Retainer

Insights on the role of cytokines in carious lesions

Contact Info

Product

Resources

About