Correlation between osmolarity measurements using the TearLab™ and I-Pen® systems in subjects with a high body mass index

Alanazi, Mana A.; El‐Hiti, Gamal A.; Alhafy, Naif; Almutleb, Essam S.; Fagehi, Raied; Alanazi, Saud A.; Masmali, Ali M.

doi:10.17219/acem/156645

Cited by 2 publications

(8 citation statements)

References 43 publications

(57 reference statements)

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“…No significant difference between the two osmometers was noted for solutions with osmolarities of 338 and 342 mOsm/L. The normal range of TF osmolarity in humans is 289–304 mOsm/L; therefore, the value measured with I‐PEN® could be higher 4,7,10,11 . In this study, eyes with low osmolarity, as measured using TearLab® (below 320 mOsm/L), tended to have higher osmolarity when measured using I‐PEN® (6 of 8 eyes).…”

Section: Discussionmentioning

confidence: 52%

“…The normal range of TF osmolarity in humans is 289-304 mOsm/L; therefore, the value measured with I-PEN® could be higher. 4,7,10,11 In this study, eyes with low osmolarity, as measured using TearLab® (below 320 mOsm/L), tended to have higher osmolarity when measured using I-PEN® (6 of 8 eyes). Conversely, in all eyes with high osmolarity, as measured using TearLab® (above 360 mOsm/L), the values obtained with I-PEN® were lower than those obtained with TearLab® (12 eyes, the average difference between the two osmometers was 40 mOsm/L).…”

Section: Discussionmentioning

confidence: 57%

“…Studies on TF osmolarity, especially on EDE, have been scarce in dogs 19 . Moreover, an assessment of research findings indicates that the clinical application of TF osmolarity measurement using osmometers in dogs is limited by higher deviations than in humans 4,7,10,11,13–16 . Because osmometers are rather sensitive, measurement errors in dogs are probably due to a lack of dog stillness during measurement.…”

Section: Discussionmentioning

confidence: 99%

“…The I‐PEN® measures TF osmolarity via the electric impedance of the ocular tissue on the palpebral conjunctival membrane 6 . In humans, the performance of the two products has been compared in several studies, and osmolarity measured with I‐PEN® is reportedly significantly higher than that measured with TearLab® 7–11 . In humans, the average osmolarity measured using TearLab® and I‐PEN® was 295.4 ± 8.6 and 319.4 ± 20.3 mOsm/L, respectively 7 …”

Section: Introductionmentioning

confidence: 99%

“…6 In humans, the performance of the two products has been compared in several studies, and osmolarity measured with I-PEN® is reportedly significantly higher than that measured with TearLab®. [7][8][9][10][11] In humans, the average osmolarity measured using TearLab® and I-PEN® was 295.4 ± 8.6 and 319.4 ± 20.3 mOsm/L, respectively. 7 In several studies on dogs, the normal TF osmolarity measured using TearLab® and I-PEN® reportedly ranges from 337-339 to 315-319 mOsm/L, respectively.…”

mentioning

confidence: 99%

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Randomized comparison of in vivo performance of TearLab® and I‐PEN® osmometry in normal dogs

Kim

2023

Veterinary Ophthalmology

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ObjectiveTo compare tear film (TF) osmolarity measured using TearLab® and I‐PEN® osmometers in the same dogs without any ocular surface disease.Animal StudiedFifty‐two dogs (98 eyes) of different breeds were evaluated.ProceduresTear film (TF) osmolarity was evaluated at 2‐min intervals. The test was randomly determined, and single measurements were performed using each osmometer. Subsequently, complete ophthalmologic examinations were performed based on Schirmer tear test‐1 (STT‐1) analysis, tear film breakup time (TFBUT), and slit‐lamp biomicroscopy. For each osmometer, the mean ± standard deviation of the TF osmolarity was calculated, and a paired Student's t‐test was used to compare the values obtained. Pearson correlation analysis was performed to assess the association between osmolarity and other values such as STT‐1, TFBUT, and age.ResultsTear film osmolarity determined using TearLab® (340.42 ± 15.87 mOsm/L) and I‐PEN® (321.58 ± 17.39 mOsm/L) were significantly different (p < .001). However, statistical significance could not be confirmed between osmolarity and other values, such as STT‐1, TFBUT, and age.ConclusionsIn dogs, the TF osmolarity values obtained using TearLab® tend to be higher than those obtained using I‐PEN®, contrary to that observed in humans. These findings can serve as a reference for establishing normal values for each osmometer for clinical use in measuring TF osmolarity in dogs.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Randomized comparison of in vivo performance of TearLab® and I‐PEN® osmometry in normal dogs

Kim

2023

Veterinary Ophthalmology

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Promising High-Tech Devices in Dry Eye Disease Diagnosis

De Luca,

Ferraro,

De Gregorio

et al. 2023

Life

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Background: Dry eye disease (DED) is a common and debilitating condition that affects millions of people worldwide. Despite its prevalence, the diagnosis and management of DED can be challenging, as the condition is multifactorial and symptoms can be nonspecific. In recent years, there have been significant advancements in diagnostic technology for DED, including the development of several new devices. Methods: A literature review of articles on the dry eye syndrome and innovative diagnostic devices was carried out to provide an overview of some of the current high-tech diagnostic tools for DED, specifically focusing on the TearLab Osmolarity System, DEvice Hygrometer, IDRA, Tearcheck, Keratograph 5M, Cornea Dome Lens Imaging System, I-PEN Osmolarity System, LipiView II interferometer, LacryDiag Ocular Surface Analyzer, Tearscope-Plus, and Cobra HD Camera. Conclusions: Despite the fact that consistent use of these tools in clinical settings could facilitate diagnosis, no diagnostic device can replace the TFOS algorithm.

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Correlation between osmolarity measurements using the TearLab™ and I-Pen® systems in subjects with a high body mass index

Abstract: Alanazi MA, El-Hiti GA, Alhafy N, et al. Correlation between osmolarity measurements using the TearLab™ and I-Pen® systems in subjects with a high body mass index [published online as ahead of print on December 8, 2022].

Cited by 2 publications

References 43 publications

Randomized comparison of in vivo performance of TearLab® and I‐PEN® osmometry in normal dogs

Randomized comparison of in vivo performance of TearLab® and I‐PEN® osmometry in normal dogs

Promising High-Tech Devices in Dry Eye Disease Diagnosis

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