Correlation between Parameters of Breathing Mechanics, Respiratory Gases and Blood Gases in Patients with Chronic Bronchial Obstruction

Reinert, Michael; Trendelenburg, Friedrich

doi:10.1159/000192889

Cited by 3 publications

(1 citation statement)

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“…Respiratory mechanics has been extensively studied during the last century ( RAHN et al, 1946 ; Otis, 1977 ; Collett et al, 1985 ; Bates, 2005 ) with resultant improvement in our understanding of the function of the respiratory system in health and disease states ( MEAD et al, 1955 ; Reinert and Trendelenburg, 1972 ; Dodd et al, 1988 ; Mador, 1991 ). Newfound knowledge of respiratory mechanics has also been applied to different animal models of respiratory disease ( Wanner and Abraham, 1982 ; Wanner et al, 1990 ; Irvin and Bates, 2003 ).…”

Section: Introductionmentioning

confidence: 99%

Lung Mechanics Over the Century: From Bench to Bedside and Back to Bench

et al. 2022

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Lung physiology research advanced significantly over the last 100 years. Respiratory mechanics applied to animal models of lung disease extended the knowledge of the workings of respiratory system. In human research, a better understanding of respiratory mechanics has contributed to development of mechanical ventilators. In this review, we explore the use of respiratory mechanics in basic science to investigate asthma and chronic obstructive pulmonary disease (COPD). We also discuss the use of lung mechanics in clinical care and its role on the development of modern mechanical ventilators. Additionally, we analyse some bench-developed technologies that are not in widespread use in the present but can become part of the clinical arsenal in the future. Finally, we explore some of the difficult questions that intensive care doctors still face when managing respiratory failure. Bringing back these questions to bench can help to solve them. Interaction between basic and translational science and human subject investigation can be very rewarding, as in the conceptualization of “Lung Protective Ventilation” principles. We expect this interaction to expand further generating new treatments and managing strategies for patients with respiratory disease.

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