Correlation between plasma homocysteine levels and craving in alcohol dependent stabilized patients

Coppola, Maurizio; Mondola, Raffaella

doi:10.1016/j.clnu.2017.05.004

Cited by 11 publications

(6 citation statements)

References 31 publications

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“…Choi and colleagues reported that hyperhomocysteinemia is related to heavy alcohol consumption and low serum levels of folate and vitamin B12 in patients who have had a stroke [26]. Similarly, Coppola confirmed that the plasma homocysteine concentration is associated with craving hazardous and harmful patterns of alcohol consumption [27]. Previously, studies have suggested a relationship between homocysteine and LVH.…”

Section: Discussionmentioning

confidence: 92%

Hyperhomocysteinemia accompany with metabolic syndrome increase the risk of left ventricular hypertrophy in rural Chinese

Chen

Yang

et al. 2020

BMC Cardiovasc Disord

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Background: To investigate the influence of hyperhomocysteinemia (HHcy) and metabolic syndrome (MetS) on left ventricular hypertrophy (LVH) in residents in rural Northeast China. Methods: We performed a cross-sectional baseline data analysis of 6837 subjects (mean age: 54 ± 10 years) recruited from a rural area of China. Anthropometric indicators were measured according to standard methods. MetS was defined by the modified ATP III criteria. HHcy was defined according to the WHO standard: an Hcy level > 15 μmol/L representing HHcy. Four groups were defined: non-HHcy & non-MetS, HHcy & non-MetS, MetS & non-HHcy and HHcy & MetS. Results: The left ventricular mass index for height 2.7 (LVMH 2.7) in both sexes was significantly higher in the HHcy & MetS group than in the non-HHcy & non-MetS group (females: 51.23 ± 16.34 vs. 40.09 ± 10.55 g-2.7 , P < 0.001; males: 48.67 ± 12.24 g-2.7 vs. 42.42 ± 11.38 g-2.7 , P < 0.001). A similar result was observed in those groups when using the left ventricular mass index (LVMI) for body surface area to define LVH (females: 103.58 ± 31.92 g − 2 vs. 86.63 ± 20.47 g − 2 , P < 0.001; males: 106.10 ± 24.69 g − 2 vs. 98.16 ± 23.29 g − 2 , P < 0.001). The results of multiple regression analysis indicated that the HHcy & MetS group had a higher risk of LVH than the other three groups (OR: 1.628 for LVMI, P < 0.001, OR: 2.433 for LVMH 2.7 , P < 0.001). Moreover, subjects in the HHcy & non-MetS group [OR (95% CI): 1.297 (1.058, 1.591) for LVMI, P < 0.05; OR (95% CI): 1.248 (1.044, 1.492) for LVMH 2.7 , P < 0.05] also had a statistically greater risk of LVH than subjects in the non-HHcy & non-MetS group. The HHcy & non-MetS group was also found to be significantly and independently associated with LVH. Conclusion: Hyperhomocysteinemia has an independent effect on LVH. The combined effect of MetS and hyperhomocysteinemia might increase the strength of the abovementioned effects.

show abstract

Section: Discussionmentioning

confidence: 92%

Hyperhomocysteinemia accompany with metabolic syndrome increase the risk of left ventricular hypertrophy in rural Chinese

Chen

Yang

et al. 2020

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

“…Choi SH and colleagues reported that hyperhomocysteinemia is related to heavy alcohol consumption and low serum levels of folate and vitamin B12 in patients who have had a stroke [26]. Similarly, Coppola M confirmed that the plasma homocysteine concentration is associated with craving hazardous and harmful patterns of alcohol consumption [27]. Previously, studies have suggested a relationship between homocysteine and LVH.…”

Section: Resultsmentioning

confidence: 91%

Hyperhomocysteinemia accompany with metabolic syndrome increase the risk of left ventricular hypertrophy in rural Chinese

Yu¹,

Chen²,

Yang³

et al. 2019

Preprint

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Background: To investigate the influence of hyperhomocysteinemia (HHcy) and metabolic syndrome (MetS) on left ventricular hypertrophy (LVH) in residents in rural Northeast China. Methods: We performed a cross-sectional baseline data analysis of 6837 subjects (mean age: 54±10 years) recruited from a rural area of China. Anthropometric indicators were measured according to standard methods. MetS was defined by the modified ATP III criteria. HHcy was defined according to the WHO standard: an Hcy level >15 μmol/L representing HHcy. Four groups were defined: non-HHcy & non-MetS, HHcy & non-MetS, MetS & non-HHcy and HHcy & MetS. Results: The left ventricular mass index for height2.7 (LVMH2.7) in both sexes was significantly higher in the HHcy & MetS group than in the non-HHcy & non-MetS group (females: 51.23±16.34 vs. 40.09±10.55 gm-2.7, P<0.001; males: 48.67±12.24 gm-2.7 vs. 42.42±11.38 gm-2.7, P<0.001). A similar result was observed in those groups when using the left ventricular mass index (LVMI) for body surface area to define LVH (females: 103.58±31.92 gm-2 vs. 86.63±20.47 gm-2, P<0.001; males: 106.10±24.69 gm-2 vs. 98.16±23.29 gm-2, P<0.001). The results of multiple regression analysis indicated that the HHcy & MetS group had a higher risk of LVH than the other three groups (OR: 1.628 for LVMI, P<0.001, OR: 2.433 for LVMH2.7, P<0.001). Moreover, subjects in the HHcy & non-MetS group [OR (95% CI): 1.297 (1.058, 1.591) for LVMI, P<0.05; OR (95% CI): 1.248 (1.044, 1.492) for LVMH2.7, P<0.05] also had a statistically greater risk of LVH than subjects in the non-HHcy & non-MetS group. The HHcy & non-MetS group was also found to be significantly and independently associated with LVH. Conclusion: Hyperhomocysteinemia has an independent effect on LVH. The combined effect of MetS and hyperhomocysteinemia might increase the strength of the abovementioned effects.

show abstract

“…Choi SH and colleagues reported that hyperhomocysteinemia is related to heavy alcohol consumption and low serum levels of folate and vitamin B12 in patients who have had a stroke [26]. Similarly, Coppola M confirmed that plasma homocysteine concentration is associated with craving hazardous and harmful patterns of alcohol consumption [27]. Previously, there are studies estimate the relationship between homocysteine and LVH.…”

Section: Discussionmentioning

confidence: 92%

Hyperhomocysteinemia accompany with metabolic syndrome increase the risk of left ventricular hypertrophy in rural Chinese

Yu¹,

Chen²,

Yang³

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: To investigate the influence of hyperhomocysteinemia (HHcy) and metabolic syndrome (MetS) on left ventricular hypertrophy (LVH) in residents in rural Northeast China. Methods: We performed a cross-sectional baseline data analysis of 6837 subjects (mean age: 54±10 years) recruited from a rural area of China. Anthropometric indicators were measured according to standard methods. MetS was defined by the modified ATP III criteria. HHcy was defined according to the WHO standard: an Hcy level >15 μmol/L representing HHcy. Four groups were defined: non-HHcy & non-MetS, HHcy & non-MetS, MetS & non-HHcy and HHcy & MetS. Results: The left ventricular mass index for height2.7 (LVMH2.7) in both sexes was significantly higher in the HHcy & MetS group than in the non-HHcy & non-MetS group (females: 51.23±16.34 vs. 40.09±10.55 gm-2.7, P<0.001; males: 48.67±12.24 gm-2.7 vs. 42.42±11.38 gm-2.7, P<0.001). A similar result was observed in those groups when using the left ventricular mass index for body surface area (LVMI) to define LVH (females: 103.58±31.92 gm-2 vs. 86.63±20.47 gm-2, P<0.001; males: 106.10±24.69 gm-2 vs. 98.16±23.29 gm-2, P<0.001). The results of multiple regression analysis indicated that the HHcy & MetS group had a higher risk of LVH than the other three groups (OR: 1.628 for LVMI, P<0.001, OR: 2.433 for LVMH2.7, P<0.001). Moreover, subjects in the HHcy & non-MetS group [OR (95% CI): 1.297 (1.058, 1.591) for LVMI, P<0.05; OR (95% CI): 1.248 (1.044, 1.492) for LVMH2.7, P<0.05] also had a statistically greater risk of LVH than subjects in the non-HHcy & non-MetS group. The HHcy & non-MetS group was also found to be significantly and independently associated with LVH. Conclusion: Hyperhomocysteinemia has an independent effect on LVH. The combined effect of MetS and hyperhomocysteinemia might increase the strength of the abovementioned effects.

show abstract

Correlation between plasma homocysteine levels and craving in alcohol dependent stabilized patients

Cited by 11 publications

References 31 publications

Hyperhomocysteinemia accompany with metabolic syndrome increase the risk of left ventricular hypertrophy in rural Chinese

Hyperhomocysteinemia accompany with metabolic syndrome increase the risk of left ventricular hypertrophy in rural Chinese

Hyperhomocysteinemia accompany with metabolic syndrome increase the risk of left ventricular hypertrophy in rural Chinese

Hyperhomocysteinemia accompany with metabolic syndrome increase the risk of left ventricular hypertrophy in rural Chinese

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