Correlation between plasma malondialdehyde and ceruloplasmin activity values in rheumatoid arthritis

Özgüneş, Hilâl; Gürer, Hande; Tuncer, Safiye

doi:10.1016/0009-9120(94)00081-6

Cited by 28 publications

(14 citation statements)

References 10 publications

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“…Our results may shed light on our current understanding of the interaction between ROS and inflammatory processes. 4,5,7,8 Our results also documented similar levels of 4-HNE in patients taking prednisolone alone or in combination with MTX as well as MTX vs. other DMARDs. The data are highly limited regarding the potential interaction between lipid preoxidation end-products and anti-rheumatic drugs, requiring further researches.…”

Section: Discussionsupporting

confidence: 71%

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Is 4-Hydroxynonenal a Predictive Parameter for the Development of Joint Erosion in Patients With Rheumatoid Arthritis?

et al. 2016

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Objectives: This study aims to evaluate serum 4-hydroxynonenal (4-HNE) levels and its clinical and radiological significance in patients with rheumatoid arthritis (RA). Patients and methods:The study included 40 patients (8 males, 32 females; mean age 51.4±11.2 years; range 24 to 72 years) with RA and 30 healthy controls (8 males, 32 females; mean age 53.0±11.7 years; range 24 to 72 years. Serum 4-HNE levels were measured using sandwich enzyme-linked immunosorbent assay method. Patients with disease activity score 28 ≤3.2 and >3.2 were allocated into low and high/moderate disease activity groups, respectively. Additionally, patients were divided into two groups as early RA (disease duration ≤2 years) and established RA (disease duration ≥2 years). Functional disability was evaluated using health assessment questionnaire. Radiographs were scored using the modified Larsen scoring. Results: Serum 4-HNE levels in patients with RA were significantly higher than controls (p=0.001). Serum 4-HNE levels did not correlate with laboratory or clinical parameters of disease activity including erythrocyte sedimentation rate, C-reactive protein, disease activity score 28, and health assessment questionnaire. Serum 4-HNE levels were higher in patients with established RA than patients with early RA (r=0.487, p=0.001). Besides, modified Larsen score which indicates structural damage correlated significantly with serum 4-HNE levels (p=0.001). Conclusion: These results indicate that serum 4-HNE levels may be used as an indicator for structural damage such as erosions in the early stage of RA; however, they are not efficient to monitor disease activity.

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Section: Discussionsupporting

confidence: 71%

“…4 ROS are considered as the mediators of tissue damage in patients with RA. 5 Numerous activated neutrophils which produce ROS accumulate in the synovial fluid of inflamed rheumatoid joint. 4 Normally, reactive oxygen radicals are produced in all cells and tissues as a result of relatively low-levels of oxidative process.…”

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confidence: 99%

Is 4-Hydroxynonenal a Predictive Parameter for the Development of Joint Erosion in Patients With Rheumatoid Arthritis?

et al. 2016

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“…3 ROS have been implicated as mediators of tissue damage in patients with RA. 4 The synovial fluid of the inflamed rheumatoid joint swarms with activated neutrophils which produce large amounts of ROS. 3 ROS are formed in oxidative processes that normally occur at relatively low levels in all cells and tissues.…”

Section: Introductionmentioning

confidence: 99%

“…Elevated levels of MDA have been observed in the serum (or plasma) and synovial fluid of RA patients. [3][4][5][6][7] The destructive chain reaction initiated by ROS can be broken by antioxidants, which are able to convert ROS into harmless derivates. 2 Vitamin E is known to be a powerful non-enzymic antioxidant.…”

Section: Introductionmentioning

confidence: 99%

Plasma lipid peroxidation and antioxidant levels in patients with rheumatoid arthritis

Kamanlı¹,

Nazıroğlu²,

Aydılek³

et al. 2003

Cell Biochemistry & Function

167

119

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In recent years, a great number of studies have investigated the possible role of reactive oxygen species in the aetiology and pathogenesis of rheumatoid arthritis (RA). The aim of this study was to investigate plasma concentrations of vitamin E, beta-carotene, activities of glutathione peroxidase (GSH-Px) and catalase, levels of lipid peroxidation (MDA) and reduced glutathione (GSH) in 36 patients with rheumatoid arthritis (RA) and 22 healthy age-matched controls. The plasma activity of GSH-Px and catalase (p < 0.001), levels of GSH (p < 0.01), concentration of beta-carotene (p < 0.05) and vitamin E (p < 0.001), haemoglobin and hematocrit (p < 0.05) were significantly lower in patients with RA than in controls. The MDA levels (p < 0.01), C reactive protein, rheumatoid factor, anti-streptolysin-o values (p < 0.001), platelet count (p < 0.05) and erythrocyte sedimentation rate (p < 0.001) were higher in the patient group than in the control group. These results provide some evidence for a potential role of increased lipid peroxidation and decreased enzymic and non-enzymic antioxidants in RA by its inflammatory character. These results suggested that oxidant stress plays a very important role in the pathogenesis of RA.

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“…The increased plasma MDA concentration in RA patients could be due to excessive generation of ROS which progresses in chronic inflammation causing tissue damage. 2,5,25,[29][30][31][32] The current study demonstrated that plasma MDA was positively correlated with titer of rheumatoid factor in the RA patients, while plasma TAP was negatively correlated with OSI and TPP. The established negative correlations observed in the current study suggest that RA patients are prone oxidative stress which leads to decreased total antioxidant capacity and increased lipid peroxidation products (MDA).…”

Section: Discussionmentioning

confidence: 90%

Oxidative stress factors in Nigerians with rheumatoid arthritis

Yeldu

Arinola

2017

Int J Res Med Sci

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Background: Rheumatoid arthritis (RA) is a chronic progressive inflammatory autoimmune disorder characterized by symmetric erosive synovitis and sometimes with multi-system involvement. But the exact mechanism of the disease is not fully understood. In the light of above explanation, the present study measured the plasma levels of total peroxide potential (TPP), total antioxidant potential (TAP), malondialdehyde (MDA), oxidative stress index (OSI) and nitric oxide (NO) in relation to the titer of rheumatoid factor among RA patients compared with controls.Methods: This study included 28 rheumatoid arthritis patients and 28 apparently healthy subjects as controls who were matched for age (50-60 years), sex, and socioeconomic status. Rheumatoid factor was estimated using latex method as described by manufacturer. Anthropometric parameters and plasma levels of TPP, TAP, OSI, MDA and NO were determined using standard techniques.Results: The result indicated that with the exception of mean body weight which was significantly (p<0.001) higher among RA patients (90.61±2.02 years) as compared with controls (77.91±2.51 years), mean age, height and body mass index of RA patients (55.68±1.05kg, 1.65±0.01m and 33.40±0.83 kg/m2 respectively) were not significantly different compared with controls (54.07±1.04kg, 1.61±0.02m and 30.44±1.28 kg/m2 respectively). Plasma TPP, NO, OSI and MDA were significantly (p<0.01; p<0.001) higher while, plasma TAP is significantly lower among RA patients compared with controls. Plasma MDA was positively correlated with titer of rheumatoid factor in the RA patients.Conclusions: Our findings therefore may raise the concept that there are some yet unknown key events in the pathogenesis of RA determination of sex of the skull along with other parameters.

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Correlation between plasma malondialdehyde and ceruloplasmin activity values in rheumatoid arthritis

Cited by 28 publications

References 10 publications

Is 4-Hydroxynonenal a Predictive Parameter for the Development of Joint Erosion in Patients With Rheumatoid Arthritis?

Is 4-Hydroxynonenal a Predictive Parameter for the Development of Joint Erosion in Patients With Rheumatoid Arthritis?

Plasma lipid peroxidation and antioxidant levels in patients with rheumatoid arthritis

Oxidative stress factors in Nigerians with rheumatoid arthritis

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