Correlation between plasminogen activator inhibitor-1 (PAI-1) promoter 4G/5G polymorphism and metabolic/proinflammatory factors in polycystic ovary syndrome

Abstract

Polycystic Ovary Syndrome (PCOS) is the most common cause of subfertility associated to metabolic disorders. The aim of this study was to correlate metabolic and proinflammatory factors in women with PCOS. The frequency of Plasminogen Activator Inhibitor-1 (PAI-1) promoter 4 G/5 G polymorphism was also compared to healthy controls. We evaluated 79 PCOS and 79 healthy women. PAI-1 levels are positively correlated with proinflammatory factors in PCOS group. 4 G allele in PAI-1 gene was more frequent in PCOS and the 4G/4 G genotype was associated with increased PAI-1 levels. A correlation between insulin resistance and proinflammatory and overweight was also observed. C-reactive protein, serum levels of vascular cell adhesion molecule-1 (sVCAM-1), Lipid Accumulation Product (LAP) and vitamin D are good tools to evaluated factors associated to cardiovascular risk in women with PCOS.

Polycystic Ovary Syndrome as a systemic disease with multiple molecular pathways: a narrative review

“…Accordingly, obese women with PCOS presented increased levels of PAI-1. Moreover, the 4G allele in PAI-1 gene was more frequent in the PCOS group, and the 4G/4G genotype was associated with the highest PAI-1 levels in this population (Sales et al 2013).…”

“…In a casecontrol study that included 79 patients with PCOS and 79 healthy controls, we have demonstrated that PAI-1 levels are positively correlated with proinflammatory factors in the PCOS group. PAI-1 has a positive correlation with glycemia, BMI, abdominal circumference, HOMA-IR, VLDL-c, LAP, triglycerides, vitamin D and soluble vascular cell adhesion molecule-1 (sVCAM-1) levels (Sales et al 2013). Accordingly, obese women with PCOS presented increased levels of PAI-1.…”

“…In addition, first-degree relatives of both genders of women with PCOS are also at increased risk of presenting the metabolic disorders associated with this syndrome (Norman et al 2007). More than 100 candidate genes have been evaluated in previous studies, most of which are related to reproductive hormones, cellular metabolism, chronic inflammation, cell proliferation, and hemostasis (Jia et al 2012;Ruan et al 2012;Sales et al 2013;Zhao et al 2016;Hosseini et al 2017;Reddy et al 2018). More recently, Genome Patients have a dysfunction in the hypothalamic-pituitary-gonadal axis, which influences steroidogenesis.…”

Peripheral blood-derived cytokine gene polymorphisms and metabolic profile in women with polycystic ovary syndrome

“…Moreover, the systemic low-grade inflammation observed in patients with PCOS is also characterized http://dx.doi.org/10.1016/j.cyto.2015.06.008 1043-4666/Ó 2015 Elsevier Ltd. All rights reserved. by elevated interleukin-18 levels, plasminogen activator inhibitor-1 levels, endothelial dysfunction, and oxidative stress [11,15,16]. New evidence suggests that the immune system exacerbates clinical features and can be associated with other important aspects of PCOS, including insulin resistance and cardiovascular disease [17,18].…”

Plasminogen Activator Inhibitor-1 -675 4G/5G Polymorphism and Polycystic Ovary Syndrome Risk: A Meta Analysis

“…During the extraction of data, 1 article was excluded owing to overlapping data [25], and 2 articles were excluded as the distribution of genotypes deviated from HWE [26,27]. 10 studies met all inclusion criteria and were included in the meta-analysis [15][16][17][18][19][20][21][22][23][24].…”