Correlation between platelet‐derived growth <scp>factor‐B</scp> gene polymorphism and coronary heart disease

Lu, Yaru; Liu, Hui; Dong, Bo; Jing-yu, Yang; Kou, Lu; Qin, Qin

doi:10.1002/jcla.24683

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…There are plenty of risk factors for CHD, including dyslipidemia, hypertension, insulin resistance, hypercoagulability, and inflammatory responses [ 3 , 4 , 5 ]. Among all risk factors, considerable attention has been paid to the roles of inflammatory responses in the development of CHD [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary Inflammatory Index and Its Association with the Prevalence of Coronary Heart Disease among 45,306 US Adults

Shi

Kong

et al. 2022

Nutrients

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Inflammation plays a pivotal in the occurrence and development of coronary heart disease (CHD). We aim to investigate the association between the Dietary Inflammatory Index (DII) and CHD in the present study. In this cross-sectional study, adult participants from the National Health and Nutrition Examination Survey (NHANES) (1999–2018) were enrolled. The social demographic information, lifestyle factors, blood biochemical measurements, dietary information, and CHD status of all the participants were systematically collected. Multivariable logistic regression was adopted to investigate the association between the risk of CHD and the DII. Besides, restricted cubic spline (RCS) analysis was used to explore whether there was a nonlinear association of the DII and CHD. Subgroup analysis stratified by sex, age, race/ethnicity, and BMI was conducted to evaluate the association of the DII and CHD among different populations. A total of 45,306 adults from NHANES (1999–2018) were included. Compared with individuals without CHD, the DIIs of the participants with CHD were significantly elevated. A positive association was observed between the DII and CHD in multivariable logistic analysis after adjusting for age, sex, race/ethnicity, education levels, smoking, drinking, diabetes, hypertension, and body mass index (BMI). Results of RCS analysis suggested a nonlinear relationship between the DII and CHD. In addition, the increment of the DII had a greater impact on female individuals compared with male individuals. The DII is closely associated with the risk of CHD. For better prevention and treatment of CHD, more attention should be paid to controlling dietary inflammation.

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Section: Introductionmentioning

confidence: 99%

Dietary Inflammatory Index and Its Association with the Prevalence of Coronary Heart Disease among 45,306 US Adults

Shi

Kong

et al. 2022

Nutrients

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“…PDGFs and PDGFR participate in a wide array of biological processes such as brosis, wound healing, in ammation, and vascular regeneration through their in uence on various cell types [18], which may be involved in the atherosclerosis pathophysiology of CAD. The relevance between PDGFs and atherosclerosis has been observed both in vivo and in vitro [19,20], with extensive attention in the eld of CAD occurrence [21,22].…”

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confidence: 99%

The Genetic Risk Score with Variants at PDGFs and PDGFRB for the Risk of Major Cardiovascular Adverse Events in Patients with Coronary Artery Disease

Xu,

Li,

Liu

et al. 2024

Preprint

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Background Previous studies linked platelet-derived growth factors (PDGFs) and its receptor beta (PDGFRB) genetic variants to coronary artery disease (CAD), but their impact on major adverse cardiovascular events (MACEs) remains unclear. Methods A cohort study of 3139 CAD patients, followed until December 1, 2022 (median 5.42 years), genotyped 13 tagSNPs in PDGFs/PDGFRB pathway genes to establish weighted genetic risk scores (wGRS). Adjusted Cox regression analyzed the association of SNPs and wGRS with MACE outcomes. The wGRS impact on traditional risk factors (TRFs) and Global Registry of Acute Coronary Events (GRACE) score for MACEs was assessed using the C-statistic, net reclassification improvement (NRI), and integrated discrimination improvement (IDI). Multiple Cox regression examined coronary artery lesion counts and MACE occurrence in wGRS groups. Results The results showed that the A allele (vs G allele) of rs246390 was associated with an increased risk of MACEs (adjusted HR = 1.171, P = 0.013) and CVD (adjusted HR = 1.174, P = 0.036). Compared to low wGRSMACE (Q1 of quintile), high wGRSMACE (Q5 of quintile) had an increased risk of MACEs with adjusted HRs of 1.441 (P = 0.006). Additionally, patients with vessel lesions in medium wGRSCVD (Q2 ~ Q4) and high wGRSCVD (Q5) groups showed significantly higher CVD incidence than those with no vessel lesion and low wGRSCVD (Q1) levels, with adjusted HRs of 2.427 and 2.724 (P < 0.001) respectively. Conclusions Variants of the PDGF-PDGFRB pathway genes contribute to the risk of MACEs after CAD; the wGRS could serve as a risk predictor of MACEs in addition to TRFs.

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Correlation between platelet‐derived growth factor‐B gene polymorphism and coronary heart disease

Liu

Dong

et al. 2022

Clinical Laboratory Analysis

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Object:The aim of the present work was to investigate the correlation of plasma platelet-derived growth factor (PDGF)-BB level and single nucleotide polymorphism (SNP, rs1800817 and rs2285094) of PDGF-B gene with the onset and stability condition of coronary heart disease (CHD).Methods: Totally, 335 subjects were included in and divided into CHD (n = 247) and control group (n = 88) according to coronary angiography. Besides, the patients in the CHD group were divided into acute coronary syndrome (ACS) group (n = 165) and stable angina pectoria (SAP) group (n = 82), based on CHD stability condition. The plasma PDGF-BB level was measured by ELISA, and the genotype of PDGF-B was examined through qPCR assay. Results:The PDGF-BB level was positively correlated with hsCRP level (r = 0.149, p < 0.05). The genotype frequencies of SNP rs1800817 and rs2285094 match Hardy-Weinberg equilibrium. There was weak linkage disequilibrium between SNP rs1800817 and rs2285094: D′ = 0.419, r 2 = 0.04, which has no correlation with CHD. There was no statistical difference in plasma PDGF-BB level among different genotypes in rs1800817 and rs2285094. There were no differences in the plasma PDGF-BB level among patients with any genotype of SNP rs1800817 and rs2285094, no matter how it was grouped. Logistic regression results indicated that the plasma PDGF-BB level was the independent risk factor of CHD onset (OR = 1.003, 95% CI 1.001-1.006, p = 0.014).Conclusions: High plasma PDGF-BB level is the risk factor of CHD and has correlation with instability of CHD. The plasma PDGF-BB level change may be related to inflammatory response. PDGF-B gene rs1800817 and rs2285094 polymorphisms are not correlated with CHD.

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Correlation between platelet‐derived growth factor‐B gene polymorphism and coronary heart disease

Cited by 4 publications

References 30 publications

Dietary Inflammatory Index and Its Association with the Prevalence of Coronary Heart Disease among 45,306 US Adults

Dietary Inflammatory Index and Its Association with the Prevalence of Coronary Heart Disease among 45,306 US Adults

The Genetic Risk Score with Variants at PDGFs and PDGFRB for the Risk of Major Cardiovascular Adverse Events in Patients with Coronary Artery Disease

Correlation between platelet‐derived growth factor‐B gene polymorphism and coronary heart disease

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