Correlation between platelet gelsolin levels and different types of coronary heart disease

Liu, Yue; Yin, Hui-jun; Jiang, Yue-rong; Xue, Mei; Chen, Ke-ji

doi:10.1007/s11434-011-4926-9

Cited by 6 publications

(5 citation statements)

References 27 publications

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“…In addition, data from our previous clinical studies demonstrated that [10, 11] platelet gelsolin was highly expressed in patients with acute coronary syndrome (ACS) and the blood stasis syndrome (BSS) of traditional Chinese medicine. Meanwhile, based on the Chinese medicine principle of “prescription to syndrome.” Platelet gelsolin may be viewed as a new target for ABC herbs.…”

Section: Discussionmentioning

confidence: 99%

“…Our previous work [9] indicated that platelet gelsolin is the main platelet differential functional protein between patients of coronary heart disease and healthy people by platelet proteomics. Studies have also shown that platelet gelsolin is highly expressed in patients with acute coronary syndrome (ACS) and the blood-stasis syndrome (BSS) of traditional Chinese medicine (TCM) [10, 11]. Gelsolin is known to have one of the key roles in extracellular actin-scavenger system (EASS) [12], but the biological role of platelet gelsolin in platelet activation of acute myocardial infarction (AMI) is unclear.…”

Section: Introductionmentioning

confidence: 99%

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Correlation between Platelet Gelsolin and Platelet Activation Level in Acute Myocardial Infarction Rats and Intervention Effect of Effective Components of Chuanxiong Rhizome and Red Peony Root

Liu

Yin

Jiang

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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The biological role of platelet gelsolin in platelet activation of acute myocardial infarction is not defined. In order to provide a potential new antiplatelet target for Chinese medicine and to elucidate the contribution of Xiongshao capsule, the effective components of Chuanxiong rhizome and red peony root, in this study, we randomly allocated Sprague Dawley rats to left anterior descending coronary artery ligation or sham surgery and different drug prophylaxis as control. We found that gelsolin is highly expressed in platelet rich plasma and lowly expressed in platelet poor plasma, accompanied by the high platelet activation level in model rats; plasma actin filaments and mean fluorescence intensity (MFI) of platelet calcium ion increased and plasma vitamin D binding protein decreased in model rats. Xiongshao capsule could inhibit the gelsolin expression in platelet rich plasma and ischemic heart tissue simultaneously and reduce the level of plasma F-actin and MFI of platelet calcium ion. Our study concludes that platelet gelsolin is an important contributor to platelet activation, and platelet gelsolin inhibition may form a novel target for antiplatelet therapy. Xiongshao capsule may be a promising Chinese medicine drug for antiplatelet and aspirin-like cardioprotection effect.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Correlation between Platelet Gelsolin and Platelet Activation Level in Acute Myocardial Infarction Rats and Intervention Effect of Effective Components of Chuanxiong Rhizome and Red Peony Root

Liu

Yin

Jiang

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…Our results confirmed that the platelet gelsolin level in BBS patients of CHD increased significantly compared with that in non-BSS patients of CHD and healthy subjects [16], revealing that gelsolin had a close relationship with BSS of CHD and indicating that platelet cytoskeletal protein may play an important role in the development of BSS of CHD. In addition, we observed a clinical correlation between the platelet gelsolin level of different types of CHD (stable CHD and acute coronary syndrome), showing that the platelet gelsolin level had a positive relation with acute coronary syndrome [17].…”

Section: Platelet Proteomics and Blood Stasis Syndrome Of Chinese Medmentioning

confidence: 68%

Platelet proteomics and its advanced application for research of blood stasis syndrome and activated blood circulation herbs of Chinese medicine

Liu

Yin

Chen

2013

Sci. China Life Sci.

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The development of novel and efficient antiplatelet agents that have few adverse effects and methods that improve antiplatelet resistance has long been the focus of international research on the prevention and treatment of cardiovascular and cerebrovascular diseases. Recent advances in platelet proteomics have provided a technology platform for high-quality research of platelet pathophysiology and the development of new antiplatelet drugs. The study of blood stasis syndrome (BSS) and activated blood circulation of traditional Chinese medicine (TCM) is one of the most active fields where the integration of TCM and western medicine in China has been successful. Activated blood circulation herbs (ABC herbs) of Chinese medicine are often used in the treatment of BSS. Most ABC herbs have antiplatelet and anti-atherosclerosis activity, but knowledge about their targets is lacking. Coronary heart disease (CHD), BSS, and platelet activation are closely related. By screening and identifying activated platelet proteins that are differentially expressed in BSS of CHD, platelet proteomics has helped researchers interpret the antiplatelet mechanism of action of ABC herbs and provided many potential biomarkers for BSS that could be used to evaluate the clinical curative effect of new antiplatelet drugs. In this article the progress of platelet proteomics and its advanced application for research of BSS and ABC herbs of Chinese medicine are reviewed. platelet proteomics, blood stasis syndrome, activated blood circulation, coronary heart disease, Chinese medicine, activated blood circulation herbs Citation:Liu Y, Yin H J, Chen K J. Platelet proteomics and its advanced application for research of blood stasis syndrome and activated blood circulation herbs of Chinese medicine.

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“…In addition, GMP-140 is a marker of platelet activation, and it can also promote platelet adhesion and aggregation, and thus plays an important role in coronary atherosclerotic plaque stability [30] . To further explore whether the GPIa C807T polymorphism regulates platelet aggregation by enhancing its activation, GMP-140 plasma levels were also investigated in subjects with different genotypes.…”

Section: Discussionmentioning

confidence: 99%

Glycoprotein Ia C807T: Polymorphisms and Their Association with Platelet Function in Patients with the Acute Coronary Syndrome

Zhang¹,

Jin²,

Shi

et al. 2015

Cardiology

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Objectives: In the current study, we explored the relationship between glycoprotein Ia (GPIa) C807T polymorphisms and platelet function, and the sensitivity to dual antiplatelet treatment after percutaneous coronary intervention. Materials and Methods: We conducted a case-control study in 220 patients diagnosed with acute coronary syndrome (ACS) and 220 healthy controls. The platelet GPIa C807T genotypes of patients and controls were determined, and platelet aggregation and plasma concentrations of α-granule membrane protein (GMP-140) were assessed following stimulation with arachidonic acid and adenosine diphosphate. Results: The frequency of the GPIa T allele was higher in the ACS group than in controls. In the ACS group, platelet aggregation was significantly higher in individuals with the T allele than in those with the C allele. Dual antiplatelet treatment reduced platelet aggregation in all three genotypes, and patients carrying the CC genotype were more sensitive to antiplatelet treatment than those with the T allele, particularly the ones with the TT genotype. There were no differences in plasma GMP-140 levels. Conclusions: The GPIa C807Tpolymorphism might be a risk factor for the development and relapse of ACS. The GP Ia T allele may help to identify a group of patients who need more aggressive antithrombotic treatment.

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Correlation between platelet gelsolin levels and different types of coronary heart disease

Cited by 6 publications

References 27 publications

Correlation between Platelet Gelsolin and Platelet Activation Level in Acute Myocardial Infarction Rats and Intervention Effect of Effective Components of Chuanxiong Rhizome and Red Peony Root

Correlation between Platelet Gelsolin and Platelet Activation Level in Acute Myocardial Infarction Rats and Intervention Effect of Effective Components of Chuanxiong Rhizome and Red Peony Root

Platelet proteomics and its advanced application for research of blood stasis syndrome and activated blood circulation herbs of Chinese medicine

Glycoprotein Ia C807T: Polymorphisms and Their Association with Platelet Function in Patients with the Acute Coronary Syndrome

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