Correlation between polymorphism of vitamin D receptor TaqI and susceptibility to tuberculosis

Li, Bin; Wen, Fei; Wang, Zhaofen

doi:10.1097/md.0000000000029127

Cited by 4 publications

(4 citation statements)

References 33 publications

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“…In their meta-analysis, Bin Li et al found a significant correlation between the VDR polymorphism of the TaqI gene and susceptibility to TB in Iranians and Indians. However, no association was found between the vitamin D receptor polymorphism TaqI and the Chinese population [59]. In their study, Mukhtar Sadykov et al found a significant association between VDR SNPs rs1544410, BsmI and rs731236, TaqI and TB [60].…”

Section: Vitamin D Levels and Afb Gradingmentioning

confidence: 86%

Comparative Study of Vitamin D Levels in Newly Diagnosed Tuberculosis and a Normal Population

Mamadapur,

Nagaraju,

Prabhu

2024

Medicina

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Background and Objectives: Tuberculosis (TB) is an ancient disease caused by Mycobacterium tuberculosis, a member of the Mycobacterium tuberculosis complex. It contributes to significant morbidity and mortality. Treatment of TB poses a considerable challenge because of emerging drug resistance and the longer duration of therapy. Various past studies, both in vitro and in vivo, have established the role of vitamin D in the pathogenesis and treatment of TB. Results of in vivo studies are inconsistent, and this study aims to determine vitamin D levels and their association with newly diagnosed TB (pulmonary and extrapulmonary) cases and normal populations. Material and Methods: A Prospective Case-Control study with 116 subjects (58 cases and 58 controls) was conducted over two years. 29 cases of pulmonary TB and 29 cases of extrapulmonary TB constituted 58 cases of TB. Vitamin D levels were measured and compared in both the cases and controls. Data analysis was carried out using SPSS software 22.0. Results: The prevalence of vitamin D deficiency was 68.96% in the cases, while it was 51.72% in the controls. The reported median and quartile of serum vitamin D levels were 14.35 ng/mL (8.65, 25.48) in the TB group and 19.08 ng/mL (13.92, 26.17) in the control group. There was a significant statistical difference between the TB and non-TB populations with a p-value of 0.029 on the Mann–Whitney test. Conclusion: Vitamin D deficiency was more prevalent in individuals with TB than those without TB.

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Section: Vitamin D Levels and Afb Gradingmentioning

confidence: 86%

Comparative Study of Vitamin D Levels in Newly Diagnosed Tuberculosis and a Normal Population

Mamadapur,

Nagaraju,

Prabhu

2024

Medicina

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“…To check the heterogeneity more precisely, the I2 test was also used. If the heterogeneity of the studies was low after the qualitative examination, the Q test ( P < 0.10) with the Chi-squared (χ 2 ) heterogeneity statistical test was used, and finally, a meta-analysis was performed ( 9 , 23 ).…”

Section: Methodsmentioning

confidence: 99%

“…The risk of contracting TB for people is between 5 and 15 percent ( 8 ). The effects of some genes in the human body have been proven on the level of TB infection in different people ( 9 , 10 ). Among the genes that affect TB are the human white blood cell antigen and white blood cell non-antigen genes.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Vitamin D Receptor Gees Polymorphisms in People with Pulmonary Tuberculosis: A Systematic Review and Meta-Analysis

Samimi,

Hossein Panahi,

Zaboli

et al. 2024

MJIRI

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Background Polymorphisms in the vitamin D receptor (VDR) play an effective role in the susceptibility of pulmonary tuberculosis (TB). Given the importance of this polymorphism and its association with pulmonary TB, this study aimed to investigate the prevalence of VDR polymorphisms in people with pulmonary TB. Methods The search process was performed from 2009 to 2023 according to PRISMA (Preferred reporting items for systematic reviews and meta-analyses). The strengthening of the reporting of observational studies in epidemiology (STROBE) checklist was used to qualify the articles. The data was entered into STATA version 14 software, then the fixed effects model and the random effects model, effect size (ES), and Q test ( P < 0.10) were used for data analysis at a confidence interval level (CI) of 95%. Two-sided statistical tests were considered with α=0.05. Results In this research, 28 articles were analyzed. Polymorphisms showed a significant relationship with susceptibility to pulmonary TB ( P = 0.000), and significant heterogeneity ( P = 0.000) was seen between polymorphisms. FokI (95% CI: 0.39-0.46, P = 0.000, ES = 43%), ApaI (95% CI: 0.31-0.48, P = 0.000, ES = 39%) and BsmI (95% CI: 0.24-0.50, P = 0.000, ES = 37%) showed the most frequent gene polymorphisms after TaqI (95% CI: 0.34-0.77, P = 0.000, ES = 56%). Conclusion ApaI, BsmI, FokI, and TaqI polymorphisms were found in patients suffering from pulmonary TB. Polymorphisms related to the TaqI gene were the most frequent. Controlling and prescribing vitamin D may be needed in these patients.

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Interleukin 4 gene polymorphisms and the risk of tuberculosis: A meta-analysis

2023

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Correlation between polymorphism of vitamin D receptor TaqI and susceptibility to tuberculosis

Cited by 4 publications

References 33 publications

Comparative Study of Vitamin D Levels in Newly Diagnosed Tuberculosis and a Normal Population

Comparative Study of Vitamin D Levels in Newly Diagnosed Tuberculosis and a Normal Population

Prevalence of Vitamin D Receptor Gees Polymorphisms in People with Pulmonary Tuberculosis: A Systematic Review and Meta-Analysis

Interleukin 4 gene polymorphisms and the risk of tuberculosis: A meta-analysis

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