Correlation between procalcitonin and intra-abdominal pressure and their role in prediction of the severity of acute pancreatitis

Bezmarević, Mihailo; Mirković, Darko; Soldatović, Ivan; Stamenković, Dušica; Mitrović, Nenad; Perišić, Nenad; Marjanovic, Ivan; Micković, Saša; Καρανικόλας, Μενέλαος

doi:10.1016/j.pan.2012.05.007

Cited by 52 publications

(32 citation statements)

References 53 publications

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“…Within 36 h of the initial symptoms, a PCT level of 0.5 ng/l or above was 81% sensitive and 86% specific for severe AP 21 . A recent study by Bezmarevic et al confirmed these results with PCT measurement 24 h after admission 32 . In contrast, Modrau et al showed only a limited additional value of PCT with a study of 75 consecutive patients 31 .…”

Section: Procalcitonin (Pct)mentioning

confidence: 65%

Laboratory markers predicting severity of acute pancreatitis

Staubli¹,

Oertli²,

Nebiker³

2015

Critical Reviews in Clinical Laboratory Sciences

190

122

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Acute pancreatitis (AP) is an inflammatory disease of highly variable severity, ranging from mild cases with low mortality to severe cases with high mortality. Numerous biomarkers have been studied as potential early predictors of the severity of this disease so that treatment can be optimally tailored to prevent complications. We aim to present and discuss the most relevant biomarkers for early severity assessment in AP that have been studied to date. We review the current literature on biomarkers that have been used to predict the severity in AP. C-reactive protein (CRP) is still considered to be the gold standard, with a cut-off value of 150 mg/ml 48 h after disease onset. Other markers, including procalcitonin (PCT) and interleukin 6 (IL-6) have been implemented in some hospitals, but are not used on a routine basis. Most other markers, including acute phase proteins (LBP, SAA, PTX3), cytokines (Il-8, TNF-a, MIF), activation peptides of pancreatic proteases (TAP, CAPAP, PLAP), antiproteases (AAT, a2M), adhesion molecules (ICAM-1, selectins, E-cadherin) and leukocyte-derived enzymes (PA2, PMN-E) have shown some promising results but have not been routinely implemented. Furthermore, new and interesting biomarkers (Copeptin, TRX-1, Ang-2, E-2) have shown good results, but more research is needed to determine if they could play a role in the future. Various reasons why new markers for disease severity have not been adopted in daily routine include low accuracy, cumbersome laboratory techniques and high cost. Despite these difficulties, research is still very active in finding new markers to predict the severity of AP.

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Section: Procalcitonin (Pct)mentioning

confidence: 65%

Laboratory markers predicting severity of acute pancreatitis

Staubli¹,

Oertli²,

Nebiker³

2015

Critical Reviews in Clinical Laboratory Sciences

190

122

View full text Add to dashboard Cite

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“…The mortality rate of acute pancreatitis with complication of ACS varies depending on the report , but a systematic review by van Brunschot et al showed a high mortality rate of 47.5% . Also, a large number of complications from organ disorder/failure have been shown.…”

Section: Resultsmentioning

confidence: 99%

Japanese guidelines for the management of acute pancreatitis: Japanese Guidelines 2015

Yokoe

Takada

Mayumi

et al. 2015

J Hepato Biliary Pancreat

364

390

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The JPN Guidelines 2015 were prepared using the most up-to-date methods, and including the latest recommended medical treatments, and we are confident that this will make them easy for many clinicians to use, and will provide a useful tool in the decision-making process for the treatment of patients, and optimal medical support. The free mobile application and calculator for the JPN Guidelines 2015 is available via http://www.jshbps.jp/en/guideline/jpn-guideline2015.html.

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“…In some studies, persistent high levels of PCT were associated with infection and or increased septic mortality in patients with sepsis [263, 264], while other studies have not confirmed PCT as an accurate marker for sepsis or to predict a patient’s response to the initial treatment [201, 265]. …”

Section: Which Inflammatory Mediators Are Involved In Intra-abdominalmentioning

confidence: 99%

Management of intra-abdominal infections: recommendations by the WSES 2016 consensus conference

et al. 2017

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This paper reports on the consensus conference on the management of intra-abdominal infections (IAIs) which was held on July 23, 2016, in Dublin, Ireland, as a part of the annual World Society of Emergency Surgery (WSES) meeting. This document covers all aspects of the management of IAIs. The Grading of Recommendations Assessment, Development and Evaluation recommendation is used, and this document represents the executive summary of the consensus conference findings.

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Correlation between procalcitonin and intra-abdominal pressure and their role in prediction of the severity of acute pancreatitis

Cited by 52 publications

References 53 publications

Laboratory markers predicting severity of acute pancreatitis

Laboratory markers predicting severity of acute pancreatitis

Japanese guidelines for the management of acute pancreatitis: Japanese Guidelines 2015

Management of intra-abdominal infections: recommendations by the WSES 2016 consensus conference

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